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Clinical And Microbiological Predictors Of Post-operative Crohn's Disease Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$120,253.00
Summary
The multi-centre randomised controlled POCER (Post-Operative Crohn’s Disease Recurrence) trial has shown that following “curative” surgery, the anti-tumour necrosis factor drug adalimumab prevents recurrent disease in almost all patients. I will examine the multiple factors that contribute to disease recurrence including assessment of mucosal microbiota, faecal biomarkers and serological antibody markers in patients with Crohn's disease. Results will improve clinical outcomes and change internat ....The multi-centre randomised controlled POCER (Post-Operative Crohn’s Disease Recurrence) trial has shown that following “curative” surgery, the anti-tumour necrosis factor drug adalimumab prevents recurrent disease in almost all patients. I will examine the multiple factors that contribute to disease recurrence including assessment of mucosal microbiota, faecal biomarkers and serological antibody markers in patients with Crohn's disease. Results will improve clinical outcomes and change international practice.Read moreRead less
The Use Of Real-World Evidence To Support Regulatory And Reimbursement Decisions
Funder
National Health and Medical Research Council
Funding Amount
$91,538.00
Summary
Traditionally, medicines are studied extensively in clinical trials before they are widely available. More recently, some medicines have been allowed to enter the market without complete data on their benefits and risks. This means that these issues can only be studied once a medicine is on the market and used in routine clinical practice; this is referred to as real-world evidence. This research evaluates if this evidence is sufficient to prove that a medicine is safe and that it works
Improving CPR Quality By Optimising The Language Used In CPR Instructions
Funder
National Health and Medical Research Council
Funding Amount
$76,365.00
Summary
A mixed methods project to determine if the quality of dispatcher assisted cardiopulmonary resuscitation (DA-CPR) can be improved by understanding and including the wording used by laypeople to describe CPR. This study will seek input from lay people through focus groups and test the effectiveness of the changes to DA-CPR instructions, with the objective to determine the impact of including these descriptions in DA-CPR instructions on the quality of CPR in a simulation study.
Joint Longitudinal And Time-to-event Models For Applications In Health Research
Funder
National Health and Medical Research Council
Funding Amount
$86,073.00
Summary
A recently developed statistical technique ("joint modelling") allows for both repeatedly measured biomarker data (for example, blood pressure measurements) and event time data (for example, time until death) to be analysed together. There are several potential benefits to using these models, but since the methods are relatively new their uptake in applied health research remains limited. This PhD will consist of several distinct but interrelated projects which explore the use of these models.
A Dietary Intervention For Sarcopenia In Cirrhosis
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Patients with chronic liver failure, or cirrhosis, suffer many complications. Sarcopenia, the loss of muscle and muscle weakness, is one of these. It is associated with reduced survival. Patients with cirrhosis have low levels of branched chain amino acids (BCAAs) which are used as building blocks for protein and energy in muscle. We aim to explore how oral supplements of BCAAs might improve muscle in this population. If this improves muscle mass, we also expect it may improve other outcomes.
Quality Of Life, Associated Psychological And Economic Family Impacts, And Trajectory Of Recovery In Aboriginal And Torres Strait Islander Paediatric Burns Patients.
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
Over a third of burns injuries in Australia are paediatric, with over representation of Aboriginal and Torres Strait Islander children. Burns are a major injury, having devastating long term consequences, connected to psychological distress, trauma, cost and disability. This research focusses on quality of life measures, economic impacts and psychological distress, investigating enabling and inhibitory factors to burns recovery in Aboriginal and Torres Strait Islander children and their family.
Determining The Natural History Of Localized High-risk Melanoma And Risk Factors For Melanoma Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$103,980.00
Summary
This PhD thesis aims to describe 2-year survival rates of patients with localised melanoma. We will investigate risk factors and patterns of melanoma spread in patients with high-risk localised lesions. Risk factors for developing ulcerated versus non-ulcerated melanomas will be explored. We aim to describe support service use in melanoma patients in rural, regional and urban areas in Queensland.
The Capacity Of Non-government Organisations To Improve The Food Supply
Funder
National Health and Medical Research Council
Funding Amount
$76,123.00
Summary
Reducing premature death from cardiovascular disease is a health priority and reducing dietary salt is vital to achieve this. Most dietary salt is in processed foods and non-government organisations (NGOs) have long advocated for less salty foods. Little is known about why some companies sell very salty foods compared to others. This research considers the influence of NGOs on the behaviour of food companies and the respective reformulation strategies, and seeks to find out why companies respond ....Reducing premature death from cardiovascular disease is a health priority and reducing dietary salt is vital to achieve this. Most dietary salt is in processed foods and non-government organisations (NGOs) have long advocated for less salty foods. Little is known about why some companies sell very salty foods compared to others. This research considers the influence of NGOs on the behaviour of food companies and the respective reformulation strategies, and seeks to find out why companies respond differently.Read moreRead less
Improving The Policy Development Process In Aboriginal Health: A Case Study Of Food And Nutrition
Funder
National Health and Medical Research Council
Funding Amount
$108,845.00
Summary
This research investigates the process through which policy decisions are made in the field of Aboriginal and Torres Strait Islander health. In this project, nutrition will be used as a case study to examine the policy-making process. This research is important because nutrition is a significant public health issue for the Aboriginal and Torres Strait Islander population. However, little is known about the process by which nutrition and other health issues become policy priorities for Government
Determining The Genetic Basis Of Skeletal Dysplasias Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$110,068.00
Summary
Osteoporosis is a common condition in Australia, yet treatment options are still limited. Study of rare genetic bone conditions known collectively as skeletal dysplasias have already led to the development of two new osteoporosis drug treatments. My project aims to identify the causative gene for several skeletal dysplasias, and to determine how these genes are involved in the development and maintenance of bone. This knowledge may then translate into new osteoporosis therapies.