Molecular Mediators, Epigenetic Modulators And Therapeutic Targets For Cognitive Disorders
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
Brain disorders constitute an enormous, and growing, burden. My research investigates how genes and environment combine to cause disorders of cognition, including dementia, schizophrenia and autism. The research will provide new insights into these disorders, at the level of molecules, cells and behaviour. I will explore how genetic and environmental factors interact, with a focus on mental activity, physical exercise and stress, which affect a range of neurological and psychiatric disorders.
Identifying The Genetic And Environmental Causes Of Congenital Malformation
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
Birth defects are common, devastating and costly to families and to society. The cause is unknown in 80% of cases. This research is helping families by finding the gene mutations that cause birth defects. Gene discoveries, in some cases, will highlight environmental factors that are important for normal embryo formation, such as oxygen levels and dietary components. By identifying gene and environmental factors associated with causing birth defects, we hope to ameliorate or prevent many cases.
Gene-environment Interactions, Experience-dependent Plasticity And Pathogenic Mechanisms In Mouse Models Of Cognitive And Affective Disorders. Mental And Physical Activity As Modulators Of Brain And Behaviour In Healthy And Diseased States.
Funder
National Health and Medical Research Council
Funding Amount
$250,805.00
Summary
Our aim is to understand how genes and environment combine to affect susceptibility to various brain disorders. We are using specific models involving human gene mutations associated with diseases, and manipulating environmental factors such as mental and physical activity. We are focused on neurological and psychiatric disorders, including Huntington’s disease, depression and schizophrenia. These efforts to understand brain diseases will facilitate development of therapeutic approaches.
Exploring The Impact Of The Built Environment On Health And Health Behaviour Outcomes And The Translation Of Evidence Into Policy And Practice
Funder
National Health and Medical Research Council
Funding Amount
$841,575.00
Summary
Globally there is growing concern about the health, social, environmental, and economic impacts of rising levels of inactivity and obesity, coupled with projected population growth, climate change, declining oil supplies and rising fuel prices. Creating pedestrian-, cycling- and transit-friendly environments and encouraging alternative forms of transport is a priority. Working with policy-makers, this research aims to influence urban planning policy to create healthy, sustainable communities.