Discovery Early Career Researcher Award - Grant ID: DE230100036
Funder
Australian Research Council
Funding Amount
$465,803.00
Summary
Tracing the epigenetic life-history of cells. Each cell of the human body contains identical genetic information that is activated in different ways to form varied cell types. This research aims to develop novel single-cell genomic technologies to explain the origins of different cell types. This project expects to discover the molecular mechanisms through which specialised cell types are formed, which has been difficult to decipher using existing methods. My novel approach will elucidate how a ....Tracing the epigenetic life-history of cells. Each cell of the human body contains identical genetic information that is activated in different ways to form varied cell types. This research aims to develop novel single-cell genomic technologies to explain the origins of different cell types. This project expects to discover the molecular mechanisms through which specialised cell types are formed, which has been difficult to decipher using existing methods. My novel approach will elucidate how a small population of seemingly homogenous cells can give rise to a myriad of types of cells. Tracing the life histories of cells across time should lead to broad applications including in developmental biology, neuroscience and immunology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101748
Funder
Australian Research Council
Funding Amount
$410,716.00
Summary
Discovering hidden control elements for crop improvement. Sustainable, productive agricultural processes are essential for tackling the challenges of tomorrow’s world. The ability to optimise beneficial agricultural traits depends on the precise control of genes in a crop plant’s enormous genome. Yet, identifying valuable gene control regions is like looking for needles in a haystack. The location of these regions is often not obvious and current detection technologies are impractically expensiv ....Discovering hidden control elements for crop improvement. Sustainable, productive agricultural processes are essential for tackling the challenges of tomorrow’s world. The ability to optimise beneficial agricultural traits depends on the precise control of genes in a crop plant’s enormous genome. Yet, identifying valuable gene control regions is like looking for needles in a haystack. The location of these regions is often not obvious and current detection technologies are impractically expensive and intensive. This project aims to develop a new technology that is expected to facilitate rapid and cost-effective discovery of all the control regions in a genome, enhancing our understanding of crop genomes and unlocking new avenues for agricultural improvement, food security and economic stability.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100184
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
Pioneering alpine epigenomics to discover adaptive genetic elements. The genetic code of native plants are yet to be explored for DNA elements that promote resilience to climate change. These elements are now ripe for discovery due to recent advances in epigenomics allowing for rapid identification. This proposal aims to discover heat-associated elements in waxy bluebells, which inhabit Australia’s vulnerable high country. Expected outcomes include new insights on gene regulatory mechanisms in n ....Pioneering alpine epigenomics to discover adaptive genetic elements. The genetic code of native plants are yet to be explored for DNA elements that promote resilience to climate change. These elements are now ripe for discovery due to recent advances in epigenomics allowing for rapid identification. This proposal aims to discover heat-associated elements in waxy bluebells, which inhabit Australia’s vulnerable high country. Expected outcomes include new insights on gene regulatory mechanisms in native plants; the generation of resources for genetic conservation, and catalysing further molecular research into Australian flora. This should provide significant benefits by revealing genome regulation in native plants, thereby improving the ability to predict the impacts of climate change.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101669
Funder
Australian Research Council
Funding Amount
$430,485.00
Summary
Polycomb Group Proteins - Shaping Chromatin Architecture to Silence Genes . This project aims to address the fundamental question of how genes are switched off by studying a group of molecular off-switches, the polycomb group proteins. The project is expected to generate new knowledge in the area of gene regulation and epigenetics by combining innovative methods of structural biology and cell biology in an interdisciplinary way. The expected outcomes include a more complete picture of the molecu ....Polycomb Group Proteins - Shaping Chromatin Architecture to Silence Genes . This project aims to address the fundamental question of how genes are switched off by studying a group of molecular off-switches, the polycomb group proteins. The project is expected to generate new knowledge in the area of gene regulation and epigenetics by combining innovative methods of structural biology and cell biology in an interdisciplinary way. The expected outcomes include a more complete picture of the molecular mechanisms that regulate gene expression and the development of novel methods to image the genome. This should provide significant benefits, such as facilitated development of gene editing tools and regulatory circuits for synthetic biology, as well as novel capabilities to image the genome at high resolution Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101449
Funder
Australian Research Council
Funding Amount
$463,399.00
Summary
How mammalian males indirectly control transmission of paternal traits. This project aims to address how environmental insults in males prior to conception are able to modify phenotype of subsequent offspring. This project expects to generate fundamental knowledge in a key biological pathway on how non-genetic factors delivered by sperm at conception are able to program the growth of the developing embryo.The knowledge generated from this project will provide understanding and biological options ....How mammalian males indirectly control transmission of paternal traits. This project aims to address how environmental insults in males prior to conception are able to modify phenotype of subsequent offspring. This project expects to generate fundamental knowledge in a key biological pathway on how non-genetic factors delivered by sperm at conception are able to program the growth of the developing embryo.The knowledge generated from this project will provide understanding and biological options for responding to, and potentially mitigating the impacts of environmental change on the mammalian reproductive system.Read moreRead less