Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel ....Rapid point-of-care detection of genomic variations for personalised medicine. Selecting treatment based on a person’s genetic profile can improve drug safety and efficacy, but the application is hampered by the inconvenience, slow result turnaround and high cost of current lab-based tests. Full implementation of personalised medicine in clinical practice requires a point-of-care testing system. This project aims to overcome the challenges involved in developing such a system by validating novel rapid genotyping methods and developing ultrasensitive real-time DNA detection that will be integrated on a single chip platform to facilitate a small, low cost and reliable test device. The technology will be readily adaptable to areas where prompt access to genomic information is valuable, such as disease diagnosis and risk prediction.Read moreRead less
Model-based estimation methods for improved classification of electroencephalographic data: application to monitoring depth of anaesthesia. This project will use advanced computing methods applied to electrical brain wave recordings to track how the brain changes as a person undergoes general anaesthesia during surgery. This will lead to better anaesthesia monitoring devices and reduce the chances of people experiencing pain during surgery or IQ deficits after the anaesthesia.
Haemodynamic investigation of flow diverter stents for the treatment of intracranial aneurysms. This project will explore the engineering of a flow diverter, an endovascular device for the treatment of brain aneurysms. The project will determine the optimal design of new types of flow diverters, which in turn could improve the effectiveness of treatments, thus reducing the associated costs of cerebral haemorrhage and stroke.
New techniques to detect fetal heart abnormalities. Australia’s national fetal death rate is 6.7 per one thousand births. In Australia’s Indigenous community it surges to 12.3 deaths per one thousand births. Early diagnosis (and management) of abnormal fetu.ses with cardiac defects will go a long way in reducing these numbers. The proposed technology will help set up easy-to-use systems for fetal cardiac abnormality screening and reduce fetal deaths and congenital heart disease burden in adult l ....New techniques to detect fetal heart abnormalities. Australia’s national fetal death rate is 6.7 per one thousand births. In Australia’s Indigenous community it surges to 12.3 deaths per one thousand births. Early diagnosis (and management) of abnormal fetu.ses with cardiac defects will go a long way in reducing these numbers. The proposed technology will help set up easy-to-use systems for fetal cardiac abnormality screening and reduce fetal deaths and congenital heart disease burden in adult life. This project will also provide domain trained researchers with cutting edge international academic and industry expertise.Read moreRead less