Discovery Early Career Researcher Award - Grant ID: DE120102503
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical sam ....Circulating tumor cell isolation and detection: an integrated microfluidic capture device based on alternating current (AC) electrohydrodynamics. The detection of circulating tumor cells in clinical samples plays a critical role in cancer diagnosis and management. This project aims to develop microfluidic technology by incorporating AC electric field-induced vortices with three-dimensional microstructured electrodes that will advance our ability to analyse rare cells and proteins in clinical samples.Read moreRead less
Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100800
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Polymer micropatches applied to the skin for integrated capture and detection of circulating biomarkers. The purpose of this project is to develop a rapid and integrated technology for user-friendly biomarker detection at the point-of-care. We expect the device to rapidly detect proteins and/or antibodies, without the need for highly trained health workers or access to scientific laboratories.
Discovery Early Career Researcher Award - Grant ID: DE140101056
Funder
Australian Research Council
Funding Amount
$380,156.00
Summary
Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-partic ....Rational Design of Plasmonic Nanoassemblies for Rapid and Multiplexed Point-of-Care Diagnosis by Surface-enhanced Raman Spectroscopy (SERS). The central aim of this project is to develop a novel technology/sensor platform for rapid, quantitative, multiplexed and highly sensitive point-of-care diagnostics using surface-enhanced Raman spectroscopy (SERS) as the read-out approach. Three-dimensional plasmonic superstructures as novel SERS labels will be synthesised and characterised at single-particle level and the choice of optimal SERS-active three-dimensional superstructures for use will be guided by empirical structure-activity correlations in combination with computer simulations. Tumour biomarkers for breast cancer will be employed as the model target for establishing the detection platform in a portable configuration for point-of-care diagnostics.Read moreRead less
Understanding and controlling bioavailability: passive dosing of persistent organic pollutants into recombinant cell bioassays. Bioassays with mammalian cell lines may replace animal testing in chemical risk assessment if issues with limited sensitivity can be overcome for very hydrophobic chemicals such as polychlorinated dibenzodioxins. The project will solve this problem by developing a polymer-release dosing technique that assures defined and constant exposure.
A novel path to environmental and human health risk assessment of transformation products. Chemical pollution is a threat to our rivers and drinking water supplies. Degradation during water treatment and in the environment may lead to persistent and toxic transformation products. This project will provide a practical and cost-efficient risk assessment strategy for transformation products - to help ensure that our drinking water is safe.
Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot ....Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot be explained by known chemicals in water samples treated with different disinfectants using a combination of chemical analysis and in-vitro bioassays. Samples with high unexplained effects will then be fractionated to isolate toxicologically relevant disinfection by-products, which will ultimately be identified with non-target chemical analysis.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100056
Funder
Australian Research Council
Funding Amount
$3,975,864.00
Summary
ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning an ....ARC Training Centre for Next-Gen Technologies in Biomedical Analysis . The Centre for Next-Gen Technologies in Biomedical Analysis will deliver workforce trained in the development of transformative technologies that will rapidly expand the Australian pharmaceutical, diagnostic and defence sector. The university-industry partnership will increase Australia’s manufacturing capability by fast tracking screening, by integrating 3D printing, advanced sensing, big data analytics, machine learning and artificial intelligence for the delivery of optimal solutions in diagnosis, treatment and wellbeing. The centre will deliver training in Industry 4.0 skills which will boost early-stage scale-up and accelerate the sector’s supply chain, which is pivotal for the Australian industries to maintain a competitive edge. Read moreRead less
Illuminating hidden processes in emissive lanthanoid complexes. This project aims to understand the antenna effect used to sensitise lanthanoid luminescence. Despite their use in modern high-tech applications, from optical fibre amplifiers (telecommunications) to luminescent probes and sensors (biological imaging), understanding is largely based on speculation or generalised 'rules-of-thumb', severely limiting progress in the field. This project will research these processes, using chemical synt ....Illuminating hidden processes in emissive lanthanoid complexes. This project aims to understand the antenna effect used to sensitise lanthanoid luminescence. Despite their use in modern high-tech applications, from optical fibre amplifiers (telecommunications) to luminescent probes and sensors (biological imaging), understanding is largely based on speculation or generalised 'rules-of-thumb', severely limiting progress in the field. This project will research these processes, using chemical synthesis, theory and spectroscopic techniques. This is expected to lead to new emissive lanthanoid-based compounds using 'a priori' approaches, with better performance than current gold standards and references. Intellectual property created will lead to new commercial products, and to creation of new Australian based spin-off/start-up companies.Read moreRead less
Portable instrument for quantification and genotyping of Cryptosporidium . Cryptosporidium is a parasitic protozoan, causing more than 48,000 deaths in children under 5 and 7.2 million disability-adjusted-life-years globally. A low-cost device that rapidly detects the parasite in drinking and recreational water is needed to enable effective disease management practices. Partnering with Advanced Universal Diagnotik, Seqwater, ALS Water and Gold Coast Water, this project aims to develop a novel de ....Portable instrument for quantification and genotyping of Cryptosporidium . Cryptosporidium is a parasitic protozoan, causing more than 48,000 deaths in children under 5 and 7.2 million disability-adjusted-life-years globally. A low-cost device that rapidly detects the parasite in drinking and recreational water is needed to enable effective disease management practices. Partnering with Advanced Universal Diagnotik, Seqwater, ALS Water and Gold Coast Water, this project aims to develop a novel device, comprising advanced microfluidics and biosensing technology for parasite quantification, genotyping and viability analysis. Expected outcomes are improved Cryptosporidium management, risk prediction, and rapid mitigation of impending outbreaks. The proposed platform has a great potential for detecting other pathogens.Read moreRead less