Improving Translation Of Evidence Into Practice For Musculoskeletal Conditions
Funder
National Health and Medical Research Council
Funding Amount
$948,684.00
Summary
Musculoskeletal conditions place a huge burden on the world’s population. Yet current trials in this field may not reflect priorities based upon this burden and few trials address well-recognised evidence-practice gaps. My fellowship will aim to transform the current ad hoc approach to Australian musculoskeletal clinical trials. It will identify the most critical unanswered questions, formulate a national research agenda, and identify best methods for optimising uptake of findings into practice.
Diabetes And Obesity: From Benchtop To Public Health
Funder
National Health and Medical Research Council
Funding Amount
$705,501.00
Summary
Obesity. Novel factors, not related to food intake or physical activity, will be explored as possible causes of obesity. The obesity paradox, in which overweight is associated with reduced mortality, will be examined. Diabetes treatment. Methods will be developed to predict which is the right drug for each individual patient. A study will test the use of nurse-led clinics. A novel insulin delivery mechanism will be developed. Novel causes and consequences of diabetes will be explored.
Prof. Simes will lead and develop research at the NHMRC Clinical Trials Centre in collaboration with major national and international cooperative groups. Research themes include integrating molecular science with trial design and embedding research routinely in health care. Projects include surgery for rectal cancer; novel targeted therapy in gastric cancer; aspirin to prevent colon cancer; placental transfusion for preterm babies; risk in heart disease; economic assessment of clinical trials.
Lung disease is a major cause of death and disability world-wide. Tuberculosis was responsible for 1.4 million deaths in 2011. Asthma and chronic obstructive pulmonary disease (COPD) have been high priority diseases in Australia for many years. It was estimated that there were over 3 million deaths attributable to particulate air pollution in 2010. In this Fellowship I will undertake a series of projects designed to improve our understanding of these diseases and their causes.