Tumour-associated Macrophages (TAMs) And Their Role In Breast Cancer Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$72,537.00
Summary
Tumour-associated macrophages (TAMs) have been implicated in breast cancer spread. Tumour cell behaviour is influenced by the surrounding environment. This study will determine the relationship of TAMs to other cell populations, if the expression of the enzyme, u-PA, in non-tumour cells within the tumour environment is important for breast cancer spread, and whether TAM precursor white blood cells home to the primary tumour and-or to the site of tumour spread before the arrival of tumour cells.