Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Resistance by cancers to established chemotherapeutics is a growing problem in the community and one that demands the development of new strategies. Chelators that target the essential element iron within cancer cells represent a novel and promising approach to this problem. The Chief Investigators represent a unique combination of expertise in coordination chemistry and the biochemistry of iron chelati ....Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Resistance by cancers to established chemotherapeutics is a growing problem in the community and one that demands the development of new strategies. Chelators that target the essential element iron within cancer cells represent a novel and promising approach to this problem. The Chief Investigators represent a unique combination of expertise in coordination chemistry and the biochemistry of iron chelation. They have discovered and characterised new chelators that show marked anticancer activity, and act by a new mechanism that overcomes problems of resistance. In this project they will pursue a course that will lead to a greater understanding of how these compounds work with the outcome that new effective anticancer drugs may emerge.Read moreRead less
Impact Of Advanced Glycation On Anti-atherogenic Properties Of High Density Lipoprotein
Funder
National Health and Medical Research Council
Funding Amount
$372,471.00
Summary
Type 2 diabetes is a rapidly growing medical problem in Australia and around the world. Diabetes affects human health through its complications and the cardiovascular complications are a cause for major concern. One of the complications is the effect on plasma lipids: it makes cholesterol carrying particles to accumulate in the blood vessels, causing atherosclerosis. We intend to investigate how diabetes modify these particles making them atherogenic.
Sphingosine Kinase: A Target For Obesity-induced Insulin Resistance
Funder
National Health and Medical Research Council
Funding Amount
$626,845.00
Summary
Insulin resistance, a characteristic of type 2 diabetes, is linked to abnormal metabolism of lipid (fat) in tissues such as liver and muscle. This project aims to identify a novel pathway which may promote a build up of lipids in liver and therefore leads to the development of type 2 diabetes. This work may provide a basis for understanding and optimizing treatment of insulin resistance by regulating the control of fat metabolism in liver.
Design of Cost-effective Compositionally Complex Alloys. This project aims to develop low-cost and corrosion resistant compositionally complex alloys and associated processes to concurrently achieve high strength and high toughness using an innovative design strategy. The project expects to overcome the major limitations of this new type of alloys, enabling their practical applications in industry, creating new knowledge of materials science. Expected outcomes include commercialisation ready ne ....Design of Cost-effective Compositionally Complex Alloys. This project aims to develop low-cost and corrosion resistant compositionally complex alloys and associated processes to concurrently achieve high strength and high toughness using an innovative design strategy. The project expects to overcome the major limitations of this new type of alloys, enabling their practical applications in industry, creating new knowledge of materials science. Expected outcomes include commercialisation ready new alloys, breakthrough fundamental understanding of the mechanisms and long-term institutional collaboration. This should provide significant benefits, such as enhancement of Australia’s capacity of alloy development and manufacturing and strengthening the country’s world leading position in this area.Read moreRead less
Biocompatible magnesium alloys with specific materials properties. This project aims to develop biocompatible magnesium alloys with highly desirable mechanical properties and degradation on demand, and the fundamental science to achieve the materials properties. Injured human bones often need biomaterials to restore function. This project’s magnesium biomaterials could change the biomaterials field by making implant removal surgery unnecessary, and avoiding the adverse tissue reactions and stres ....Biocompatible magnesium alloys with specific materials properties. This project aims to develop biocompatible magnesium alloys with highly desirable mechanical properties and degradation on demand, and the fundamental science to achieve the materials properties. Injured human bones often need biomaterials to restore function. This project’s magnesium biomaterials could change the biomaterials field by making implant removal surgery unnecessary, and avoiding the adverse tissue reactions and stress shielding typically associated with conventional implanting metals. The outcomes are expected to provide insights in designing biodegradable magnesium alloys and surface coating technology, and generate intellectual properties and advanced biomaterials that will benefit the Australian ageing population.Read moreRead less
The development of lead-free silicon brass for the plumbing industry. The worldwide brass industry is currently undergoing a transition away from lead-containing brass water fittings to lead-free fittings. The transition is driven by concerns surrounding lead-leaching into drinking water. This project is focussed on the development of new lead-free brasses that can be used to manufacture plumbing fittings with superior combinations of processability, performance and cost.
An Integrated Approach To Identify The Molecular Mechanisms Contributing To The Pathogenesis Of Insulin Resistance: Targeting The Liver And Skeletal Muscle
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
The inability of muscle and liver to utilise sugar from the blood is a major problem that contributes to the development of obesity and diabetes. How these problems occur is unknown. The goal of my research is to identify what causes the muscle and liver problem, and whether fixing these problems will reduce obesity and diabetes. Since the number of people with obesity and diabetes is predicted to double over the next decade, we need to understand the cause of these diseases.
Discovery Early Career Researcher Award - Grant ID: DE160100357
Funder
Australian Research Council
Funding Amount
$345,000.00
Summary
Ultrastable metallic glasses. The aim of this project is to create a new class of amorphous alloy – ultrastable metallic glass – by a relatively simple vapour-deposition route. These materials are expected to exhibit unprecedentedly low energy states and properties of high thermal stability, elastic modulus, strength, and hardness not achievable in metallic glasses produced by conventional routes. These new materials may also provide a platform for addressing the longstanding issues of relaxatio ....Ultrastable metallic glasses. The aim of this project is to create a new class of amorphous alloy – ultrastable metallic glass – by a relatively simple vapour-deposition route. These materials are expected to exhibit unprecedentedly low energy states and properties of high thermal stability, elastic modulus, strength, and hardness not achievable in metallic glasses produced by conventional routes. These new materials may also provide a platform for addressing the longstanding issues of relaxation dynamics in glassy physics. The unique properties of ultrastable metallic glasses are expected to make them useful in a range of applications, including highly wear- and corrosion-resistant coatings on electronics and biomedical devices and components.Read moreRead less
Many heart diseases are associated with impairment of energetics of the heart. Improving the heart's energetics can lead to improved survival and long-term outcomes. Perhexiline is a heart medication that works by improving the way the heart uses energy. Although effective, it is associated with long-term toxicities. Better understanding of this medication may lead to less adverse effects and also provide a basis for further investigation of drug development in the future.
The design of new die-castable bulk metallic glasses exhibiting superior mechanical performance. The most dramatic illustration of non-equilibrium processing of a metal is the formation of an amorphous solid that can possess physical and/or functional properties superior to its equilibrium crystalline counterpart. This project will generate new types of net-shape-processed amorphous alloys with an excellent combination of properties.