Impact Of Advanced Glycation On Anti-atherogenic Properties Of High Density Lipoprotein
Funder
National Health and Medical Research Council
Funding Amount
$372,471.00
Summary
Type 2 diabetes is a rapidly growing medical problem in Australia and around the world. Diabetes affects human health through its complications and the cardiovascular complications are a cause for major concern. One of the complications is the effect on plasma lipids: it makes cholesterol carrying particles to accumulate in the blood vessels, causing atherosclerosis. We intend to investigate how diabetes modify these particles making them atherogenic.
Sphingosine Kinase: A Target For Obesity-induced Insulin Resistance
Funder
National Health and Medical Research Council
Funding Amount
$626,845.00
Summary
Insulin resistance, a characteristic of type 2 diabetes, is linked to abnormal metabolism of lipid (fat) in tissues such as liver and muscle. This project aims to identify a novel pathway which may promote a build up of lipids in liver and therefore leads to the development of type 2 diabetes. This work may provide a basis for understanding and optimizing treatment of insulin resistance by regulating the control of fat metabolism in liver.
Biocompatible magnesium alloys with specific materials properties. This project aims to develop biocompatible magnesium alloys with highly desirable mechanical properties and degradation on demand, and the fundamental science to achieve the materials properties. Injured human bones often need biomaterials to restore function. This project’s magnesium biomaterials could change the biomaterials field by making implant removal surgery unnecessary, and avoiding the adverse tissue reactions and stres ....Biocompatible magnesium alloys with specific materials properties. This project aims to develop biocompatible magnesium alloys with highly desirable mechanical properties and degradation on demand, and the fundamental science to achieve the materials properties. Injured human bones often need biomaterials to restore function. This project’s magnesium biomaterials could change the biomaterials field by making implant removal surgery unnecessary, and avoiding the adverse tissue reactions and stress shielding typically associated with conventional implanting metals. The outcomes are expected to provide insights in designing biodegradable magnesium alloys and surface coating technology, and generate intellectual properties and advanced biomaterials that will benefit the Australian ageing population.Read moreRead less
The development of lead-free silicon brass for the plumbing industry. The worldwide brass industry is currently undergoing a transition away from lead-containing brass water fittings to lead-free fittings. The transition is driven by concerns surrounding lead-leaching into drinking water. This project is focussed on the development of new lead-free brasses that can be used to manufacture plumbing fittings with superior combinations of processability, performance and cost.
An Integrated Approach To Identify The Molecular Mechanisms Contributing To The Pathogenesis Of Insulin Resistance: Targeting The Liver And Skeletal Muscle
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
The inability of muscle and liver to utilise sugar from the blood is a major problem that contributes to the development of obesity and diabetes. How these problems occur is unknown. The goal of my research is to identify what causes the muscle and liver problem, and whether fixing these problems will reduce obesity and diabetes. Since the number of people with obesity and diabetes is predicted to double over the next decade, we need to understand the cause of these diseases.
Ultra-lightweight alloys with unique multi-dimensional property profiles. Lightweight alloys with high specific-strength are an essential prerequisite in modern and future technologies. To be useful, they must also possess ductility and inherent corrosion resistance. The latter two properties, however, are inversely correlated with strength. This project proposes to break this paradox - not only in terms of a paradigm change regarding multi-property alloy design - but as applied to the most ligh ....Ultra-lightweight alloys with unique multi-dimensional property profiles. Lightweight alloys with high specific-strength are an essential prerequisite in modern and future technologies. To be useful, they must also possess ductility and inherent corrosion resistance. The latter two properties, however, are inversely correlated with strength. This project proposes to break this paradox - not only in terms of a paradigm change regarding multi-property alloy design - but as applied to the most lightweight engineering alloy system in existence, Magnesium-Lithium (Mg-Li), for which the impact on specific properties is immense. The aim is to develop ultra-lightweight Mg-Li based alloys with formidable property profiles via alloy design and thermomechanical processing. The expected outcome is a new class of structural corrosion resistant metal.Read moreRead less
ENHANCED PERFORMANCE OF AUTOMOTIVE SHEET ALLOYS VIA CONTROL OF COMPOSITION, THERMAL PROCESSING AND NANOSTRUCTURE. This project involves characterisation using modern facilities of the form and identity of atomic-scale clusters of alloying elements in selected automotive sheet alloys that have been subjected to single and multiple ageing treatments and examination and modelling of deformation mechanisms and behaviour in such alloys. The aim is to establish the precise role of clusters of solute a ....ENHANCED PERFORMANCE OF AUTOMOTIVE SHEET ALLOYS VIA CONTROL OF COMPOSITION, THERMAL PROCESSING AND NANOSTRUCTURE. This project involves characterisation using modern facilities of the form and identity of atomic-scale clusters of alloying elements in selected automotive sheet alloys that have been subjected to single and multiple ageing treatments and examination and modelling of deformation mechanisms and behaviour in such alloys. The aim is to establish the precise role of clusters of solute atoms and vacancies in the formation of precipitate phases that control the final strength and deformation behaviour of the alloys, and to provide useful guidelines for further improvements in strength of these alloys via the control of alloy composition and of multiple ageing treatments.Read moreRead less
Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at le ....Unlocking the diverse property profile of ultra-lightweight magnesium alloys. This project aims to develop the theory behind why micro alloying contributes to the formation of surface film properties. The exemplar is a prototype Magnesium-Lithium (Mg-Li) base alloy, with high specific-strength and corrosion resistance. This project will lead to the development of a new processable ultra-lightweight, corrosion resistant Mg-Li alloy family that is stronger than the prototype alloy, and with, at least, comparable ductility and corrosion resistance. Not only will the outcomes of the work be a fundamental advance to the fields of metallurgy and corrosion science, they will lead to the identification of an optimised compositional window for creating our second generation Mg-Li alloy family capable of being manufactured into ultra-lightweight, corrosion resistant metal products.Read moreRead less
New biocompatible titanium alloys for next-generation metallic biomaterials. This project aims to develop a new class of titanium alloy biomaterials with enhanced mechanical compatibility, biocompatibility, and bio-functionality. The project expects to generate new knowledge in phase transformation mechanisms and advanced surface modification techniques for these alloys. Expected outcomes also include developments in phase transformation theories that enable high yield strength and low Young's m ....New biocompatible titanium alloys for next-generation metallic biomaterials. This project aims to develop a new class of titanium alloy biomaterials with enhanced mechanical compatibility, biocompatibility, and bio-functionality. The project expects to generate new knowledge in phase transformation mechanisms and advanced surface modification techniques for these alloys. Expected outcomes also include developments in phase transformation theories that enable high yield strength and low Young's modulus, and innovations in manufacturing techniques for new titanium alloys. This project will provide significant benefits to both Australian healthcare providers and bone-implant recipients through greater implant lifespans, improved patient outcomes and valuable savings to the healthcare system.Read moreRead less
Lower-cost processing of formable magnesium alloys. This project aims to develop higher speed extrusion and rolling of magnesium alloys through the enhanced control of alloying elements and processing schedules. Expected outcomes of this project include the development of novel alloys and processing technologies that can produce lighter, better performing magnesium products with lower processing costs. This project will deliver magnesium products that can improve fuel efficiency, resulting in lo ....Lower-cost processing of formable magnesium alloys. This project aims to develop higher speed extrusion and rolling of magnesium alloys through the enhanced control of alloying elements and processing schedules. Expected outcomes of this project include the development of novel alloys and processing technologies that can produce lighter, better performing magnesium products with lower processing costs. This project will deliver magnesium products that can improve fuel efficiency, resulting in lower emissions and less environmental pollution, along with lightweight portable consumer goods.Read moreRead less