Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Resistance by cancers to established chemotherapeutics is a growing problem in the community and one that demands the development of new strategies. Chelators that target the essential element iron within cancer cells represent a novel and promising approach to this problem. The Chief Investigators represent a unique combination of expertise in coordination chemistry and the biochemistry of iron chelati ....Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Resistance by cancers to established chemotherapeutics is a growing problem in the community and one that demands the development of new strategies. Chelators that target the essential element iron within cancer cells represent a novel and promising approach to this problem. The Chief Investigators represent a unique combination of expertise in coordination chemistry and the biochemistry of iron chelation. They have discovered and characterised new chelators that show marked anticancer activity, and act by a new mechanism that overcomes problems of resistance. In this project they will pursue a course that will lead to a greater understanding of how these compounds work with the outcome that new effective anticancer drugs may emerge.Read moreRead less
Design of Cost-effective Compositionally Complex Alloys. This project aims to develop low-cost and corrosion resistant compositionally complex alloys and associated processes to concurrently achieve high strength and high toughness using an innovative design strategy. The project expects to overcome the major limitations of this new type of alloys, enabling their practical applications in industry, creating new knowledge of materials science. Expected outcomes include commercialisation ready ne ....Design of Cost-effective Compositionally Complex Alloys. This project aims to develop low-cost and corrosion resistant compositionally complex alloys and associated processes to concurrently achieve high strength and high toughness using an innovative design strategy. The project expects to overcome the major limitations of this new type of alloys, enabling their practical applications in industry, creating new knowledge of materials science. Expected outcomes include commercialisation ready new alloys, breakthrough fundamental understanding of the mechanisms and long-term institutional collaboration. This should provide significant benefits, such as enhancement of Australia’s capacity of alloy development and manufacturing and strengthening the country’s world leading position in this area.Read moreRead less
Light steel roof and wall systems under combined wind and bushfire actions. The project aims to investigate the complex behaviour of light cold-formed-steel roof and wall systems involving localized failures under the combined action of wind and bushfire using wind suction tests at elevated temperatures combined with advanced numerical modelling. It will generate new knowledge of the behaviour and strength of cold-formed-steel roof and wall systems under bushfire conditions. Expected outcomes in ....Light steel roof and wall systems under combined wind and bushfire actions. The project aims to investigate the complex behaviour of light cold-formed-steel roof and wall systems involving localized failures under the combined action of wind and bushfire using wind suction tests at elevated temperatures combined with advanced numerical modelling. It will generate new knowledge of the behaviour and strength of cold-formed-steel roof and wall systems under bushfire conditions. Expected outcomes include new design models for wind, bushfire and cold-formed-steel Standards. This will significantly improve the bushfire safety of buildings, since non-combustible steel roof and wall systems are used as building envelopes in bushfire prone areas, but are not designed to withstand recently discovered bushfire-enhanced winds.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100156
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Advanced Laser Additive Manufacturing System for Extended Applications to Surface Engineering, Direct Manufacturing and New Alloy Development. Advanced laser additive manufacturing system for extended applications to surface engineering, direct manufacturing and new alloy development: This project will provide an advanced laser additive manufacturing system for extended applications. Although the facility was originally designed for forefront additive manufacturing, it enables innovative resear ....Advanced Laser Additive Manufacturing System for Extended Applications to Surface Engineering, Direct Manufacturing and New Alloy Development. Advanced laser additive manufacturing system for extended applications to surface engineering, direct manufacturing and new alloy development: This project will provide an advanced laser additive manufacturing system for extended applications. Although the facility was originally designed for forefront additive manufacturing, it enables innovative research on surface engineering to solve the long standing corrosion and wear problems associated with metal components and to produce biomedical coatings on titanium implants. The facility can also be used to develop high quality alloys, including titanium and magnesium alloys, through an accelerated metallurgy approach, leading to breakthrough progress in metal research. Such alloys are highly desired by automotive and aerospace industries to improve fuel efficiency through weight reduction. Read moreRead less
New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry suppl ....New Lead-Free Brass Solutions for Drinking Water Applications. The aim of this Linkage Project is to provide viable material solutions to address the health problem of Lead-contamination in drinking water arising from Leaded-brass plumbing products and the impact Lead-removal from brass will have on the brass industry. In order to achieve this, this project engages leading multidisciplinary researchers along with Australian and international industry partners from across the brass industry supply and sales network. This project seeks to identify and harness the key material-product attributes required to develop and implement new, lead-free alloy alternatives that meet health-compliance, production and commercial viability, that offer benefits across the industry network and health benefits to society.Read moreRead less
Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population a ....Biodegradable magnesium alloy scaffolds for bone tissue engineering. This project aims to develop a class of porous, biocompatible, biofunctional and biodegradable magnesium alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for tissue engineering applications. These magnesium alloy scaffolds will be biocompatible, able to bear loads, and will be gradually replaced by natural bone. The outcomes are expected to benefit the ageing population and people with bone abnormalities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101759
Funder
Australian Research Council
Funding Amount
$385,720.00
Summary
A novel fundamental approach to enable net shape manufacturing of low-cost high-performance titanium alloys . Oxygen is the bottleneck issue of titanium powder metallurgy, which radically deteriorates the ductility of titanium. This project aims to develop the essential fundamental knowledge and technical solutions to mitigate the detrimental effect of oxygen on the ductility of as-sintered titanium products and enable the net-shape fabrication of low-cost high-performance titanium alloys. This ....A novel fundamental approach to enable net shape manufacturing of low-cost high-performance titanium alloys . Oxygen is the bottleneck issue of titanium powder metallurgy, which radically deteriorates the ductility of titanium. This project aims to develop the essential fundamental knowledge and technical solutions to mitigate the detrimental effect of oxygen on the ductility of as-sintered titanium products and enable the net-shape fabrication of low-cost high-performance titanium alloys. This will be achieved by utilising the inexpensive and unique titanium hydride powder, rather than titanium metal powder, and by developing effective oxygen scavengers. The outcomes will form a robust basis for the creation of a viable titanium hydride powder metallurgy business.Read moreRead less
Net shape manufacturing of titanium alloys by powder metallurgy. This project is aiming at developing a novel net shape manufacturing for advanced materials (titanium alloys) and addresses Priority Goal of Advanced Materials of Research Priority 3: Frontier Technologies for Advanced Materials. It represents new science and innovative engineering and has the potential to produce valuable new intellectual property.
Nonlinear modelling, analysis and prediction of optimal conditions for cold roll forming. This project investigates fundamental analytical and experimental aspects of the highly nonlinear process of cold roll forming of flat steel strip to shaped product in order to gain predictive understanding and determine optimal process conditions. The project aims to develop an innovative software system that will permit operators to balance and optimize mill productivity, energy consumption, mill downtim ....Nonlinear modelling, analysis and prediction of optimal conditions for cold roll forming. This project investigates fundamental analytical and experimental aspects of the highly nonlinear process of cold roll forming of flat steel strip to shaped product in order to gain predictive understanding and determine optimal process conditions. The project aims to develop an innovative software system that will permit operators to balance and optimize mill productivity, energy consumption, mill downtime, and product change over times and facilitate the development of new productsRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100003
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Flexible forming facility for low cost light weight applications. Flexible forming facility for low-cost light-weight applications: This project will establish Australia’s first flexible roll forming facility. The facility will be unique in the world, being specifically designed to roll form the most advanced high strength alloys into complex three-dimensional shapes and investigate their material behaviour under a wide range of loading conditions. This technology represents a step change in com ....Flexible forming facility for low cost light weight applications. Flexible forming facility for low-cost light-weight applications: This project will establish Australia’s first flexible roll forming facility. The facility will be unique in the world, being specifically designed to roll form the most advanced high strength alloys into complex three-dimensional shapes and investigate their material behaviour under a wide range of loading conditions. This technology represents a step change in commercial processing and has the capacity to form materials with high strength and limited ductility. This will lead to the development of new techniques for the manufacture of new advanced materials including advanced high strength steels, composites, nano structured metals and light metal alloys for automotive and aerospace applications.Read moreRead less