Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100018
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Purchase of a high resolution Nuclear Magnetic Resonance spectrometer with liquid chromatography module. A high resolution Nuclear Magnetic Resonance spectrometer and liquids separation module will support Tasmanian research of international significance across the biological and medical sciences, chemistry and Tasmanian industries including profiling studies in human health, plant biology, molecular basis of disease and complex mixture analysis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100021
Funder
Australian Research Council
Funding Amount
$2,168,000.00
Summary
Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low c ....Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low cost, to address biological and biomedical research needs. This project is expected to make Australian scientists globally competitive in the life sciences including biological, clinical and biomedical, plant and crop sciences, analytical chemistry, toxicology, agriculture, wildlife conservation and sports science, and to drive advances in the data sciences for systems biology.Read moreRead less
Understanding how RNA editing regulates RNA fate. This project aims to address how RNA editing mediated by ADAR1 alters the interactions of targeted RNA with the innate immune sensing system. ADAR1 editing converts adenosine to inosine within double stranded RNA. It is known that this is key to prevent activation of the innate immune sensor MDA5 by endogenous RNA. However, we do not understand why edited RNA is tolerated and unedited RNA is not. This project will generate new knowledge regarding ....Understanding how RNA editing regulates RNA fate. This project aims to address how RNA editing mediated by ADAR1 alters the interactions of targeted RNA with the innate immune sensing system. ADAR1 editing converts adenosine to inosine within double stranded RNA. It is known that this is key to prevent activation of the innate immune sensor MDA5 by endogenous RNA. However, we do not understand why edited RNA is tolerated and unedited RNA is not. This project will generate new knowledge regarding the effect of editing on how endogenous RNA is perceived by the innate immune system.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100239
Funder
Australian Research Council
Funding Amount
$480,000.00
Summary
Small biological molecule tissue imaging mass spectrometry facility for Western Australia for spatial metabolomics and lipidomics. This tissue imaging facility for Western Australia will provide researchers with access to much needed instrumentation. The facility will support major research efforts in key disciplines, including agriculture and animal science, fisheries and medical science.
Discovery Early Career Researcher Award - Grant ID: DE120102556
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The influence of crosstalk between protein post-translational modifications on the propagation of molecular signals. The ability of a cell to respond appropriately to its surroundings is a result of interactions between proteins and chemical modifiers termed post-translational modifications (PTM). This project will show how PTM interactions (competition/ cooperation) influence cellular outcomes in response to changes in the environment.
Imaging Mass Spectrometry (IMS), a peptide biomarker discovery tool using tissue. Cancer is the second most common cause of death in Australia. The newly developed technology of Imaging Mass Spectrometry for peptides in tissue has the potential to discover biomarkers for early diagnosis of cancer. This new technology could avoid a number of cancer deaths and reduce suffering of patients through earlier and better diagnosis.
The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyami ....The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyamines, as we have discovered that polyamines are regulated by iron at 2-major levels, involving >10-key polyamine pathway proteins. This proposal represents first-in-field studies specifically designed to dissect mechanisms involved in this relationship. Our Central Hypothesis is that iron regulates polyamine metabolism.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100036
Funder
Australian Research Council
Funding Amount
$771,000.00
Summary
Nuclear magnetic resonance spectroscopy facilities - Advancing cutting-edge chemical, biological, energy and materials research in Western Australia. Nuclear magnetic resonance spectroscopy facilities: advancing cutting-edge chemical, biological, energy and materials research: This project will establish new nuclear magnetic resonance spectroscopy facilities supporting high-throughput metabolite detection, diffusion measurement, and small-volume sample identification. The project will support re ....Nuclear magnetic resonance spectroscopy facilities - Advancing cutting-edge chemical, biological, energy and materials research in Western Australia. Nuclear magnetic resonance spectroscopy facilities: advancing cutting-edge chemical, biological, energy and materials research: This project will establish new nuclear magnetic resonance spectroscopy facilities supporting high-throughput metabolite detection, diffusion measurement, and small-volume sample identification. The project will support research across diverse priorities including: energy and minerals; ecology, evolution and the environment; and medicine and health. The project will open new opportunities for areas such as metabolomics and oil and gas processing, and greatly expand capacity to meet strongly increasing demand.Read moreRead less
DNA end resection: from basic mechanisms to genome editing. The project aims to understand processes underlying genome editing, a bioengineering process that introduces specific mutations into genomic DNA. Homologous recombination and nonhomologous end-joining pathways play a crucial role in repairing broken DNA strands, which are a toxic form of DNA damage. The proteins that function in the repair process have been recently identified, but it remains unclear how they function on a mechanistic l ....DNA end resection: from basic mechanisms to genome editing. The project aims to understand processes underlying genome editing, a bioengineering process that introduces specific mutations into genomic DNA. Homologous recombination and nonhomologous end-joining pathways play a crucial role in repairing broken DNA strands, which are a toxic form of DNA damage. The proteins that function in the repair process have been recently identified, but it remains unclear how they function on a mechanistic level and how either of the two main pathways is selected. The project aims to define how the activity of a key control protein, Sae2 (Sporulation in the Absence of Spo Eleven), is regulated by posttranslational modifications, and how this activates homologous recombination. The project plans to first use Saccharomyces cerevisiae yeast as a model and then to extend research into the human system in an attempt to improve the efficiency of genome editing. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH180100006
Funder
Australian Research Council
Funding Amount
$4,995,391.00
Summary
ARC Research Hub for Medicinal Agriculture . The ARC Research Hub for Medicinal Agriculture aims to transform the production of high quality plant-derived therapeutics into an integrated, national industry that spans primary producers and manufacturers. The Hub will establish a multi-disciplinary collaboration with industry. This Hub will address agronomy and cultivation, germplasm generation, novel extraction technologies and chemistries, through to the discovery and functional characterisation ....ARC Research Hub for Medicinal Agriculture . The ARC Research Hub for Medicinal Agriculture aims to transform the production of high quality plant-derived therapeutics into an integrated, national industry that spans primary producers and manufacturers. The Hub will establish a multi-disciplinary collaboration with industry. This Hub will address agronomy and cultivation, germplasm generation, novel extraction technologies and chemistries, through to the discovery and functional characterisation of novel lead compounds. This knowledge will be applicable across related industries and build the specialised workforce needed to underpin Australia’s developing medicinal agriculture industry.Read moreRead less