Apoptosis is a fundamental mechanism in regulating normal development and preventing cancer. Cancer cells must avoid apoptosis and also adapt to harsh metabolic environments in order to survive in the absence of effective nutrient supply and to resist the action of certain drugs. This project will provide a detailed analysis of metabolic changes allowing cells to survive long periods when the apoptotic process is absent and nutrients are limiting.
Matching Supply And Demand: How Does Metabolism Fine-tune Signal Transduction?
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Insulin controls nutrient traffic and disrupting its actions are linked to many diseases: type 2 diabetes, cancer, heart disease. Here, I will test a novel hypothesis that our cells’ metabolic rate, defined by the balance between nutrient supply and energy expenditure, controls how cells respond to insulin. These metabolic regulatory nodes would play a major determinant of many essential functions linked to human health, and thus provide novel therapeutic targets for numerous diseases.
A Lipidomics Approach In The Prediction Of Unstable Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$302,383.00
Summary
Despite our best efforts at lowering the ñbadî LDL-cholesterol with statins, heart disease remains the leading cause of death in Australia. One of the biggest problems is early detection of the disease. We know that people with heart disease have abnormal lipid levels. From a single blood sample, we aim to develop and optimize our lipid profiling techniques so that we can provide a cheaper but faster and more accurate test to determine those individuals who may be at much higher risk of a heart ....Despite our best efforts at lowering the ñbadî LDL-cholesterol with statins, heart disease remains the leading cause of death in Australia. One of the biggest problems is early detection of the disease. We know that people with heart disease have abnormal lipid levels. From a single blood sample, we aim to develop and optimize our lipid profiling techniques so that we can provide a cheaper but faster and more accurate test to determine those individuals who may be at much higher risk of a heart attack or stroke.Read moreRead less
Plasma Metabolomic Profiling Of Patients With Serial Coronary Atheroma Progression For Predicting Myocardial Infarction And Death
Funder
National Health and Medical Research Council
Funding Amount
$373,114.00
Summary
Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new ag ....Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new agent that dramatically lowers cholesterol.Read moreRead less