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Disturbances Of DNA Regulation In Obesity, And Their Relationships To Metabolic Health
Funder
National Health and Medical Research Council
Funding Amount
$354,074.00
Summary
We have shown there exists significant differences in methylation patterns between Obese patients and healthy controls. In this study we will refine our understanding of the relationship between methylation and obesity. Our study will provide insight into how methylation changes observed in obesity influence downstream metabolic disorders such as diabetes and cardiovascular disease.
Protective Mechanisms Of MAP Kinase Phosphatase 5 In Adipose Tissue Fibrosis, Hepatic Steatosis And Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$352,729.00
Summary
Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.
Bacterial Metabolite Mediated Regulation Of The Immune And Metabolic Systems
Funder
National Health and Medical Research Council
Funding Amount
$303,374.00
Summary
The cellular and molecular events that underpin metabolic syndrome diseases, such as diabetes, fatty liver, etc are poorly understood. However recent advances provide new clues. First, the immune system is intimately connected to metabolism. Second, the gut microbiota, and its metabolites such as acetate and butyrate are also important. These metabolites induce epigenetic changes in cells. We will study how metabolites induce molecular changes epigenetically, and how this controls metabolism.
Analysis Of Metabolic Profiles In Young Adults From The The Western Australian Pregnancy Cohort (Raine) Study By Metabolomics: Biomarkers For Metabolic Consequences Of Early Programming By Infant Feeding Type
Funder
National Health and Medical Research Council
Funding Amount
$337,681.00
Summary
Increasing evidence from European and other investigators around the world demonstrates that early nutrition has long-lasting programming effects for later health and disease risk. The most convincing evidence is for obesity and its associated disorders, that include metabolic syndrome, diabetes, cardiovascular disease, asthma and certain cancers. The focus of this project is on the increasing public health importance and intergenerational nature of these problems.
Identifying Novel Lipid And Genetic Signatures Of Metabolic Disease In Early Childhood
Funder
National Health and Medical Research Council
Funding Amount
$354,592.00
Summary
Both our genetic makeup and environment can contribute to the development of obesity, diabetes and heart disease. Although onset usually occurs in adulthood, the progression towards disease can start in early life. Early childhood represents an opportunity for intervention to avoid adverse health outcomes in adulthood. This proposal combines two established birth cohorts from Singapore (GUSTO) and Australia (BIS) to examine the genetic and environmental origins of metabolic diseases.
Sleep-wake Disturbances And Cardio-metabolic Dysfunction In At Risk Dementia: A Novel Pathway In Neurocognitive Decline’
Funder
National Health and Medical Research Council
Funding Amount
$558,305.00
Summary
Age-related sleep and circadian disturbance and cardio-metabolic dysfunction are associated with an increased risk of dementia. This research aims to delineate the pathway in which sleep and circadian disturbances and cardio-metabolic dysfunction promote cognitive decline during the ‘at risk’ dementia phase. This will improve our understanding of key processes in cognitive ageing ultimately leading to the development of targeted intervention programs in the quest to delay the onset of dementia.
Forging A New Understanding Of Iron In Neurodegenerative Disease.
Funder
National Health and Medical Research Council
Funding Amount
$598,573.00
Summary
Using the versatile model system, C. elegans, this proposal will define how normal functions of the brain become corrupted with age and hijacked by neurodegenerative diseases to cause dementia. Coupling specialised X-ray imaging only available at the Australian Synchrotron with the research excellence of the University of Melbourne, this Fellowship will provide a better understanding of normal ageing and how this relates to the development and progression of neurodegenerative diseases.
Fostering Responsive Mental Health Systems In The Syrian Refugee Crisis
Funder
National Health and Medical Research Council
Funding Amount
$499,989.00
Summary
The current refugee crisis across Europe and the Middle East effects both individual refugees’ psychological well-being, as they face extreme stressors in their flight from their home country. In response to this crisis, this project aims to provide a framework for scaling-up the delivery and uptake of effective community-based mental health strategies to address the specific needs of refugees with mental health problems in ways that are affordable and can be delivered to millions of refugees.
Early Nutrition, Epigenetics And Developmental Outcomes In Children.
Funder
National Health and Medical Research Council
Funding Amount
$550,093.00
Summary
Increasing evidence demonstrates that early nutrition, including in pregnancy, has long lasting programming effects on later health of children. Evidence implicates epigenetics (literally ‘above DNA’) in mediating these effects. The most convincing data exists for obesity and related disorders such as metabolic syndrome, diabetes, and heart disease. The focus of this project is on understanding how ‘epigenetic’ mechanisms are influencing the way our genes function to cause these disorders.
Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$719,770.00
Summary
Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.