ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $400,885.00
Summary: Studies show that body mass index, midlife adiposity and diabetes are associated with Parkinson's disease (PD). During obesity there is a dramatic change in nutritional information, such as hormones, sugars and fats, carried in the blood. This proposal explores how this altered nutritional information in obesity kills the brain cells associated with PD. It will examine how ghrelin, a metabolic hormone inversely related to obesity, influences and protects brain cell activity in models of PD.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $73,361.00
Summary: Obesity and its associated health risks are a developing world problem. Fat is not distributed uniformly in an individual; females have more subcutaneous, and males more abdominal, fat. Abdominal fat is associated with the health risks of obesity. The aims of the current project are to examine the neuronal pathways from the brain to fat and the chemicals involved in order to better understand the way in which fat distribution is determined in the body and develop appropriate therapies.

Funded Activity

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $221,210.00
Summary: This project is about the study of central regulation of energy balance contributing to prevention or development of chronic high-energy diet-induced obesity. Obesity is a major predisposing factor for a variety of life threatening diseases such as type II diabetes, hypertension, and coronary heart disease with their enormous costs both socially and economically. Development of human obesity and its related metabolic disorders generally develops over a long period and eventually becomes a chroni ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $553,236.00
Summary: Currently there are limited therapeutic treatments and no cure for Alzheimer's disease (AD). The key protein causing AD is called Abeta. Abeta peptides form dityrosine cross-linked dimers (when 2 peptides join together) and this is thought to be responsible for killing brain cells in AD. Therefore, this proposal will determine the role of Abeta dimers in relation to killing brain cells and the progression of AD through analysis of their biological and biochemical properties.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $333,313.00
Summary: The majority of studies into Alzheimer's disease (AD) have focussed on two brain lesions- the plaque and neurofibrillary tangle (NFT), which are believed to have a causative role in AD. Our lab has made several seminal discoveries about the role that metals play in the development of plaques. We are now extending this work to evaluate the role of metals in NFT formation. These studies will provide insight into the formation and possible treatments for this primary brain lesion in AD.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $346,446.00
Summary: The experiments outlined in this project proposal are aimed at further characterizing a genetically engineered mouse the generation of which was originally funded by the Australian NH and MRC. The mutant mouse suffers from the loss of brain cells in a part of the brain called the striatum. The mouse model will allow us to understand how damage to brain structures cause disabling human neurodegenerative diseases such as Parkinsonism and Huntington's disease. The mouse model is unique as the mice ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $605,151.00
Summary: The number of people with dementia is increasing in Australia as people live longer. Dementia sometimes has a genetic basis and identification of such cases has improved our understanding of the events leading to the destruction of the brain tissue. In the vast majority of people, the degenerative changes were previously thought to be as a result of Alzheimer's disease. However, our recent research, funded by the NHMRC, confirms international findings showing more than 25% of people with dementi ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $547,994.00
Summary: Parkinson's disease is caused by premature death of nerve cells that control body movements. The enzyme PINK1 protects against nerve cell death by chemically modifying specific cellular proteins that maintain cell survival. We aim at identifying these proteins and investigating how PINK1-catalysed modification modulates their ability to maintain nerve cell survival. The study will benefit development of drugs that protect against nerve cell death for treatment and prevention of the disease.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $392,750.00
Summary: Alzheimer s disease accounts for the majority of dementia cases and is the most common cause for nursing home requirements in Australia. It is not a disease that is confined to old age as it can also affect individuals in their 20s and 30s. There is currently no cure for Alzheimer's disease, largely because the underlying cause is unknown. Deposition of the amyloid-beta protein within the brain of Alzheimer's disease patients is thought to be responsible for the neuronal cell loss which underlie ....
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