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The Role Of Thymocyte Self-renewal In Causing T Cell Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$586,594.00
Summary
Recurrence of acute leukamia after therapy is due to the presence of immature cells that can self-renew, a process that is normally restricted to stem cells. Through the study of mice that develop leukaemia, we have identified these very rare self-renewing cells that are resistant to standard therapies. We can identify and measure these cells many months before leukaemia develops. As such, we will use this mouse model to understand how these cells self-renew and how they can be killed