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Structural-functional connectivity in the brain. This project aims to develop magnetic resonance imaging analysis methods to non-invasively study brain connectivity. Recent advances in imaging can comprehensively describe the brain’s complex network of functional and structural connections (the brain ‘connectome’). This project will simultaneously investigate structural and functional connectivity, and characterise the dynamic properties of the connectome using graph-theoretic approaches. This p ....Structural-functional connectivity in the brain. This project aims to develop magnetic resonance imaging analysis methods to non-invasively study brain connectivity. Recent advances in imaging can comprehensively describe the brain’s complex network of functional and structural connections (the brain ‘connectome’). This project will simultaneously investigate structural and functional connectivity, and characterise the dynamic properties of the connectome using graph-theoretic approaches. This project should give neuroscientists computational tools to comprehensively map the network architecture of the human brain.Read moreRead less
Improving Productivity in Emergency Service Personnel. Emergency service personnel experience marked levels of lost productivity, absenteeism, early retirements, and compensation claims as a result of stress reactions. This project aims to improve productivity and reduce compensation costs in emergency service organisations by evaluating a program that reduces stress reactions and increases cognitive functioning in police, firefighters, and paramedics in NSW. An individual program will be admini ....Improving Productivity in Emergency Service Personnel. Emergency service personnel experience marked levels of lost productivity, absenteeism, early retirements, and compensation claims as a result of stress reactions. This project aims to improve productivity and reduce compensation costs in emergency service organisations by evaluating a program that reduces stress reactions and increases cognitive functioning in police, firefighters, and paramedics in NSW. An individual program will be administered to 120 emergency service personnel who have difficulty maintaining their work duties because of stress reactions. Expected outcomes will be reduction in absenteeism, improved productivity, and reduced costs to insurers.
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Engineered extrasynaptic GABAA receptors: Towards novel analgesics. Engineered extrasynaptic GABAA receptors: Towards novel analgesics. This project intends to alleviate neuropathic pain by developing drugs and good tool molecules targeting GABA-A receptors. About 20% of Australian adults suffer from neuropathic pain. Delta-containing GABA-A receptors represent attractive and novel targets for developing non-opioid analgesics. However, no drugs or good tool molecules target these receptors. This ....Engineered extrasynaptic GABAA receptors: Towards novel analgesics. Engineered extrasynaptic GABAA receptors: Towards novel analgesics. This project intends to alleviate neuropathic pain by developing drugs and good tool molecules targeting GABA-A receptors. About 20% of Australian adults suffer from neuropathic pain. Delta-containing GABA-A receptors represent attractive and novel targets for developing non-opioid analgesics. However, no drugs or good tool molecules target these receptors. This project intends to develop the needed enabling technologies, including screening assays, tool molecules and radioligands; and perform brain slice electrophysiology to confirm activity in neuronal cells. This project is expected to benefit the research community and future rational drug-discovery endeavours for drugs that modulate delta-containing receptors.Read moreRead less
Mapping and manipulating fear prediction errors. This project plans to use Pavlovian conditioning to map and then manipulate the brain architecture of fear prediction errors. It asks fundamental questions about how Pavlovian conditioning and associative learning enable us to learn to fear, to reduce fear, and to respond appropriately to danger. It aims to answer these questions with behavioural sophistication and previously unobtainable cell-type, temporal, and circuit-level precision. It aims t ....Mapping and manipulating fear prediction errors. This project plans to use Pavlovian conditioning to map and then manipulate the brain architecture of fear prediction errors. It asks fundamental questions about how Pavlovian conditioning and associative learning enable us to learn to fear, to reduce fear, and to respond appropriately to danger. It aims to answer these questions with behavioural sophistication and previously unobtainable cell-type, temporal, and circuit-level precision. It aims to provide new insights into the mechanisms of Pavlovian conditioning, associative learning, and emotion: insights that are necessary to shape the next generation of theoretical accounts and practical applications.Read moreRead less
How the brain parses danger signals. This project aims to use Pavlovian conditioning to map and manipulate the brain circuitry for attentional selection of danger signals. It will investigate how we attend to and learn about sources of danger in the world with behavioural sophistication and previously unobtainable cell-type, temporal and circuit level precision. It aims to provide insights into the mechanisms of Pavlovian conditioning, associative learning, and emotion: insights that are necessa ....How the brain parses danger signals. This project aims to use Pavlovian conditioning to map and manipulate the brain circuitry for attentional selection of danger signals. It will investigate how we attend to and learn about sources of danger in the world with behavioural sophistication and previously unobtainable cell-type, temporal and circuit level precision. It aims to provide insights into the mechanisms of Pavlovian conditioning, associative learning, and emotion: insights that are necessary to shape the next generation of theoretical accounts and practical applications.Read moreRead less
Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between ....Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between these factors is unknown. The outcomes of the current grant will provide the first evidence of that link, thus providing deeper understanding of the neurophysiological mechanisms of these disorders, which could eventuate in the creation of more beneficial treatments. Read moreRead less
Resonance: a digital media art work for cooperative group interaction in the rehabilitation of acquired brain injury. The project, titled 'resonance', encompasses the design and development of an interactive multimedia artwork for rehabilitation of Acquired Brain Injury (ABI). The artwork will promote cooperative group interaction between patients, enhancing their motor and cognitive recovery.