Emerging Severe Mental Illness In Young People: Clinical Staging, Neurobiology, Prediction & Intervention From Vulnerabi
Funder
National Health and Medical Research Council
Funding Amount
$6,229,421.00
Summary
Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis f ....Mental disorders, such as psychotic and severe mood disorders, are the largest cause of disability in Australia. However, there is still little known about illness onset, relapse and progression. We have developed a clinical staging model with transition points from symptomfree to subthreshold status, to threshold disorder to chronic disability. We will investigate neurobiological and psychosocial factors which increase the risk of progression through these stages and use this model as a basis for examining the effectiveness of interventions, for example to prevent, delay or ameliorate onset and relapse, and promote vocational recovery. Thus major clinical and public health benefits and an understanding of factors that contribute to the onset and progression of illness will result.Read moreRead less
Theoretically Guided Improvement In The Treatment Of Social Phobia: A Randomised Controlled Trial.
Funder
National Health and Medical Research Council
Funding Amount
$302,830.00
Summary
Social phobia is a serious mental disorder that affects up to 13% of the population across their lifetime and causes marked life interference and costs to the community. Treatments for social phobia have been improving over the past decades and currently, there is good outcome with standard treatment packages. However, several authors have pointed out that treatment outcomes, while good, are far from perfect. We have recently developed a model of social anxiety that points out how people with so ....Social phobia is a serious mental disorder that affects up to 13% of the population across their lifetime and causes marked life interference and costs to the community. Treatments for social phobia have been improving over the past decades and currently, there is good outcome with standard treatment packages. However, several authors have pointed out that treatment outcomes, while good, are far from perfect. We have recently developed a model of social anxiety that points out how people with social phobia may be different to the average. Based on this model, we can make several predictions for potential improvements to current treatment packages. The current grant seeks to test these improvements. The proposal is to compare people with social phobia who receive a standard treatment package with those who receive this packaged plus the newly predicted components. It is predicted that the addition of these extra components will results in considerably greater improvements in both the short and long terms.Read moreRead less
Enhanced Treatment For Social Phobia Through The Incorporation Of Attentional Re-training.
Funder
National Health and Medical Research Council
Funding Amount
$465,162.00
Summary
Social phobia is a serious difficulty that can cause tremendous interference in an individual's life. Social phobia can interfere with an individual's social and romantic life, work and study aspirations, and even increase medical and other psychological problems. Psychological programs to help individuals manage their anxiety have been developed and shown to lead to relatively strong positive outcomes. Recent theoretical understanding has suggested that one maintaining factor in social phobia m ....Social phobia is a serious difficulty that can cause tremendous interference in an individual's life. Social phobia can interfere with an individual's social and romantic life, work and study aspirations, and even increase medical and other psychological problems. Psychological programs to help individuals manage their anxiety have been developed and shown to lead to relatively strong positive outcomes. Recent theoretical understanding has suggested that one maintaining factor in social phobia may be these people's tendency to focus onto negative information. In some exciting developments, several researchers have shown that simply training people with social phobia to focus their attention away from negative information, with no other treatment components, can produce a marked change in their fears. Therefore it makes sense that incorporating these methods into current standard treatment packages, may increase their effectiveness. The current study aims to compare the current best practice treatment package for social phobia with a combination of this package plus the recent attention re-training methods. It is expected that incorporating attention re-training into standard treatment with significantly improve its effects.Read moreRead less
Novel Epidemiological Methods To Infer The Causal Effects Of Risk Factors On Neuropsychiatric And Cardiovascular Disorders
Funder
National Health and Medical Research Council
Funding Amount
$182,003.00
Summary
Epidemiological studies, which associate risk factors and disease, are central in informing public health policy. Because causality is difficult to ascertain from these associations, public health interventions based on these findings are at some risk of failure. We propose to develop, extend and apply an innovative epidemiological approach, Mendelian randomization (MR) to resolve the causal relationship between risk factors and neuropsychiatric and cardiovascular disorders.
Evidence-based Mental Health Planning: Translating Evidence Into Policy And Services
Funder
National Health and Medical Research Council
Funding Amount
$2,442,370.00
Summary
The CRE will design a better mental health system for Australia. This service system will include the full range of prevention and treatment interventions using the best available scientific evidence. It will also describe how to ensure that the service system is implemented, by incorporating it into government policy. The work will be carried out across 5 of the best research centres in Australia with expertise in clinical medicine, epidemiology, service planning and implementation science.
Understanding The Pathology Of Muscarinic Receptor Deficit Schizophrenia: A Biochemically Defined Form Of The Disorder.
Funder
National Health and Medical Research Council
Funding Amount
$451,804.00
Summary
Schizophrenia is a group of disorders with similar symptoms and no way of distinguishing the different disorders. In our brain collection 25% of the subjects with schizophrenia have a particular chemical deficit. Screening gene expression in people with schizophrenia, with and without this deficit will give a global picture of chemical differences between the groups. Understanding the differences between sub-groups of people with schizophrenia will aid the development of better drugs for them.
The Role Of Stress, HPA-axis Dysfunction And CNS Structural And Functional Change In The Development Of Psychosis.
Funder
National Health and Medical Research Council
Funding Amount
$345,538.00
Summary
This research will further understanding of the processes underlying the development of serious mental illnesses such as schizophrenia and may lead to the development of strategies to prevent these devastating disorders. Although there have been advances in the management of psychotic disorders in recent years, their underlying causes remain largely unknown. We aim to investigate the potential roles of stress, HPA-axis function and structural and functional brain changes. The neurodevelopmental ....This research will further understanding of the processes underlying the development of serious mental illnesses such as schizophrenia and may lead to the development of strategies to prevent these devastating disorders. Although there have been advances in the management of psychotic disorders in recent years, their underlying causes remain largely unknown. We aim to investigate the potential roles of stress, HPA-axis function and structural and functional brain changes. The neurodevelopmental model of psychosis suggests that small structural CNS changes occur very early in life conferring a degree of vulnerability on the affected individual. We propose that the psychological and neurobiological processes listed above interact with the pre-existing vulnerability, resulting in the development of psychotic symptoms. This is in line with the stress-vulnerability model of psychosis. We aim to investigate this model by monitoring the level of stress reported by young people at risk of psychosis over 12 months. We will also obtain measures of their biological response to stress by assessing cortisol levels over time and brain structure and functioning will be assessed. By monitoring these processes in the high risk group, we will be able to identify any changes that occur if a psychotic illness develops. This research also has practical applications in the identification of young people at high risk of developing a psychotic disorder, Moreover it will inform the development of medical and psychological strategies aimed at preventing or delaying the onset of schizoprenia and related illnesses in the high risk population.Read moreRead less
Beyond Motherhood: A 27-year Follow-up Of The Mental Health Of Mid-age Women.
Funder
National Health and Medical Research Council
Funding Amount
$1,755,651.00
Summary
There have been few studies of the causes and consequences of anxiety disorders yet they are disabiling, chronic and impair life prospects particularly for women. Environmental factors hold the greatest promise to understanding their natural history and for mitigating their effects. This proposal is for a 27 year follow up of women participating in the Mater University Study of Pregnancy to understand the development of anxiety disorders and comorbid depression and substance use.