Identification Of Genes For X-linked Mental Retardation.
Funder
National Health and Medical Research Council
Funding Amount
$675,228.00
Summary
We propose to identify novel heritable causes of intellectual disability using 22 large and well-characterised families from Australia. In these families we have refined the location of the genetic defect to the chromosome X and excluded the contribution of all so far known genes. We will achieve this using the technology of massive parallel sequencing. At the completion of the project we will have identified novel causes of intellectual disability and devised tests to identify them.
The Australian Centre For Research Excellence In Offender Health
Funder
National Health and Medical Research Council
Funding Amount
$2,646,826.00
Summary
Offenders are one of the most marginalised groups in society and endure the worst health outcomes in regards to mental health, exposure to bloodborne viruses and sexually transmissible infections, and engagement in health risk behaviours. Incarceration devastates Indigenous communities and we urgently need for solutions to reduce Aboriginal prisoner numbers. The research proposed by this CRE in mental health and infectious diseases will improve health outcomes for offenders and provide treatment ....Offenders are one of the most marginalised groups in society and endure the worst health outcomes in regards to mental health, exposure to bloodborne viruses and sexually transmissible infections, and engagement in health risk behaviours. Incarceration devastates Indigenous communities and we urgently need for solutions to reduce Aboriginal prisoner numbers. The research proposed by this CRE in mental health and infectious diseases will improve health outcomes for offenders and provide treatment solutions rather than incarceration.Read moreRead less
An investigation of the cognitive processes underlying intrusive traumatic cognition. Intrusive unpleasant thoughts and memories occur in sufferers of anxiety and depression, and are common in normal individuals. Understanding the processes underlying intrusive cognition is critical, especially in the present world climate in which the Australian public is increasingly confronted with threats of terrorism and other negative world events. This research will have the direct benefit of leading to i ....An investigation of the cognitive processes underlying intrusive traumatic cognition. Intrusive unpleasant thoughts and memories occur in sufferers of anxiety and depression, and are common in normal individuals. Understanding the processes underlying intrusive cognition is critical, especially in the present world climate in which the Australian public is increasingly confronted with threats of terrorism and other negative world events. This research will have the direct benefit of leading to improved health of sufferers of anxiety and depression in the Australian community, and has the potential to increase normal individuals' ability to contribute to society by reducing intrusions that can interfere with work productivity, promote absenteeism, and have a negative impact on general wellbeing.Read moreRead less
Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and t ....Single and dual process models of recognition memory: Reconciliation of behavioural, electrophysiological, and neuroimaging data. Advanced brain scanning technologies are increasingly used to study human memory. As well as being important for our basic understanding of memory, they also tell us how memory is affected by normal development, ageing, disease, and injury. Unfortunately, because these technologies are so new, a gap has opened up between our psychological understanding of memory and the physiological events measured by the scanning technologies. This has created a problem for how we should interpret the results that are found. The present project aims to close this gap by applying new research methodologies and theoretical insights based on our previous research.Read moreRead less
Influences on farmer suicide in Queensland and New South Wales. Australian farmers have been identified as being at high-risk of suicide. This project will provide direction for targeted suicide prevention strategies by quantifying the individual and environmental factors that place farmers at higher risk of suicide, as well as the protective factors that may buffer against suicide and suicidal behaviours.
Children's memory for traumatic events. Many children are exposed to negative and distressing events. Understanding the processes underlying memories of such events is critical, especially in the present world climate in which the Australian public is increasingly confronted with threats of terrorism and other negative world events. This research will contribute directly to understanding why some children develop maladaptive responses to major life events, and others appear to adjust with few ps ....Children's memory for traumatic events. Many children are exposed to negative and distressing events. Understanding the processes underlying memories of such events is critical, especially in the present world climate in which the Australian public is increasingly confronted with threats of terrorism and other negative world events. This research will contribute directly to understanding why some children develop maladaptive responses to major life events, and others appear to adjust with few psychological difficulties. The research will pinpoint better management strategies for children affected by trauma by improved understanding of how traumatic memories are developed, as well as identifying critical variables that are amenable to change early after trauma exposure.Read moreRead less
Normative study of a checklist of emotional and behavioural disturbance in adults with intellectual disability. People with intellectual disability (ID) are three times more likely to suffer mental illness than the general community, making this a bigger problem than schizophrenia. They are a great burden to their carers and cost to the community but their mental health problems remain largely untreated. This study aims to conduct the largest and most comprehensive survey of the mental health ....Normative study of a checklist of emotional and behavioural disturbance in adults with intellectual disability. People with intellectual disability (ID) are three times more likely to suffer mental illness than the general community, making this a bigger problem than schizophrenia. They are a great burden to their carers and cost to the community but their mental health problems remain largely untreated. This study aims to conduct the largest and most comprehensive survey of the mental health of adults with ID that has been undertaken internationally to date. The population will cover the age span of late adolescence (16 years) through the transition to adult life then through to the elderly. The research will establish the prevalence and nature of mental illness and potential risk factors in a large representative population of adults with ID.Read moreRead less
A prospective study of the mental health of grandparents providing part-time child care for their preschool age grandchildren. This project addresses national research priorities and will identify the characteristics of a high-risk subgroup of Australian grandparents for whom the childcare burden has a deleterious impact on health and well being. Results will enable development of improved approaches to education and awareness in health professionals and the lay community about this subgroup, fa ....A prospective study of the mental health of grandparents providing part-time child care for their preschool age grandchildren. This project addresses national research priorities and will identify the characteristics of a high-risk subgroup of Australian grandparents for whom the childcare burden has a deleterious impact on health and well being. Results will enable development of improved approaches to education and awareness in health professionals and the lay community about this subgroup, facilitating early identification and intervention. The study will provide evidence-based guidance to policy makers about the most appropriate support services for grandparents involved in high levels of childcare, reducing their level of stress and improving the quality of the childcare they provide.
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Neourobiology Of Human Epilepsy: Genes, Cellular Mechanisms,network And Whole Brain
Funder
National Health and Medical Research Council
Funding Amount
$17,652,824.00
Summary
The team is comprised of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discovery of the genetic causes of epilepsy. They will continue to identify genes underlying epilepsy and study how genetic variations result in development of seizures. Advanced brain imaging will be used to understand the effects of genetic variation on brain structure and function. This study may lead to new diagnostic methods and treatments for epilepsy.