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The Causes, Treatment, And Prognosis Of Thyroid Disease
Funder
National Health and Medical Research Council
Funding Amount
$190,445.00
Summary
The thyroid gland controls body metabolism and is crucial to life. Disorders of the thyroid place a severe burden on the health system. Yet despite this, much is unknown about the causes, optimal treatments, and prognosis of thyroid disease. In this NHMRC Early Career Fellowship, Don aims to advance knowledge and improve treatments of these common conditions, focusing on thyroid cancer, Graves’ disease, and Hashimoto’s thyroiditis.
Trials To Prevent The Transmission And Complications Of Sexually Transmitted Infections, Including HIV
Funder
National Health and Medical Research Council
Funding Amount
$306,123.00
Summary
Sexually transmitted infections (STIs) are important causes of illness in some sectors of the community. Even though they can be effectively prevented and treated, many health services do not give them priority. This research project will study ways in which general practitioners can better diagnose and treat STIs. We will carry out trials that compare new approaches to supporting doctors in this area, that involve a mixture of training, reminders and technical support as needed.
Evaluating Coronary Stents Using High-resolution Optical Coherence Tomography Imaging In Patients With Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
A stent is a device made of metal that is placed inside an artery to prop it. Recently, the applicant introduced into Australia a novel technology to examine these stents once inside the body. This information may help make stents safer for patients
Improving The Genetic Diagnosis Of Neuromuscular Disorders
Funder
National Health and Medical Research Council
Funding Amount
$338,836.00
Summary
Neuromuscular disorders involve progressive muscle weakness where currently there are no effective specific treatments, and only a diagnostic rate of ~60%; thus emphasising the great need for research into gene discovery and disease mechanisms. The use of genomics technologies can increase the diagnosis rate but challenges still remain. This project aims to address these challenges by developing tools and workflows to improve the diagnostic rate of neuromuscular diseases.
Thalassaemia is the most common blood disorder worldwide. In severe cases, life-long blood transfusions are needed to survive but complications including iron overload and bone disease can occur. Deferasirox, a drug used to treat iron overload has been linked to kidney stones and bone loss in these patients through increased loss of calcium in the urine. The purpose of this study is to investigate whether bone loss can be reversed by using a diuretic or an alternative iron chelator.
Optimising Large-scale Public Health Interventions To Control Neglected Tropical Diseases
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Neglected tropical diseases (NTD) are a group of health conditions that affect the poorest of the poor, particularly in remote and rural areas. They affect the most vulnerable communities and cause substantial, chronic health harms impairing personal and social development. Several debilitating NTD are common in remote indigenous communities and Pacific islands. I propose a series of studies to investigate new strategies to control NTD in large populations where these diseases are endemic.
Mapping Brain Network Interactions In Neurodegenerative Disorders Of The Subcortex
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Huntington’s disease, Parkinson’s disease, and Friedreich ataxia are debilitating and progressive neurodegenerative disorders that result from cell death within different components of a common brain system. Using magnetic resonance imaging and advanced statistical techniques, I will investigate functional and structural changes within this system, providing a clearer picture of the brain network changes that underlie the expression of these disorders.