Pore Engineering of Chromatography Membranes for Bioseparation. Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and technique ....Pore Engineering of Chromatography Membranes for Bioseparation. Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and techniques in the fields of reactive polymer synthesis, functional membrane fabrication and application in bioseparation. The innovative membranes developed in the project are able to improve the production capacity of therapeutic protein manufacturing processes, providing significant economic benefits to Australia.Read moreRead less
A humanised sensory neuron high-throughput screening platform . Sensory neurons are responsible for converting external stimuli such as touch or temperature into graded electrical signals that allow us to interact with the world around us. However, unlike other cell types, sensory neurons cannot proliferate and thus must be removed from human cadavers, or animals, in order to study their pharmacology and function. This limits our ability to understand neuronal signalling pathways. This project a ....A humanised sensory neuron high-throughput screening platform . Sensory neurons are responsible for converting external stimuli such as touch or temperature into graded electrical signals that allow us to interact with the world around us. However, unlike other cell types, sensory neurons cannot proliferate and thus must be removed from human cadavers, or animals, in order to study their pharmacology and function. This limits our ability to understand neuronal signalling pathways. This project aims to use sensory neurons derived from human stem cells to develop and optimise assays that can be used to study the pharmacology and function of human sensory neurons in vitro. This enhances access to critical model systems and technology platforms and removes the need for isolation of cells from cadavers. Read moreRead less
Mitigation of silica nanoparticle scaling in water treatment. This project aims to develop strategies to mitigate silica scaling at coal seam gas (CSG) water treatment facilities. CSG is adsorbed to the surface of coal along fractures and cleats and released when pressure is reduced by removal of groundwater, which has chemistry specific to the region from which it is extracted. Desalination of produced water is severely impacted by mineral scaling on reverse osmosis membranes. This project will ....Mitigation of silica nanoparticle scaling in water treatment. This project aims to develop strategies to mitigate silica scaling at coal seam gas (CSG) water treatment facilities. CSG is adsorbed to the surface of coal along fractures and cleats and released when pressure is reduced by removal of groundwater, which has chemistry specific to the region from which it is extracted. Desalination of produced water is severely impacted by mineral scaling on reverse osmosis membranes. This project will consider silica and silica-rich nanoparticles in concert with cations and organics, with the aim of better managing cations so to facilitate nanoparticle lubrication. Project outcomes may include more productive use of assets, improved pre-treatment infrastructure to support reverse osmosis operation, and the environmental benefits of reduced chemical waste and increased water recovery.Read moreRead less