Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Flotation separation of nanoparticles. This project deals with the separation of fine nanoparticles suspended in water, by attachment to small gas bubbles. It aims to find a way of removing nanoparticles from water, or of separating one species from another. The process could be used for simple solids such as metal oxides, and for biological materials such as large molecules, viruses and small bacteria. The work will be both theoretical and experimental. This ground-breaking project will build u ....Flotation separation of nanoparticles. This project deals with the separation of fine nanoparticles suspended in water, by attachment to small gas bubbles. It aims to find a way of removing nanoparticles from water, or of separating one species from another. The process could be used for simple solids such as metal oxides, and for biological materials such as large molecules, viruses and small bacteria. The work will be both theoretical and experimental. This ground-breaking project will build upon past successes of the applicant, whose invention in the field of resource recovery is contributing close to $1 billion a year to Australia's exports.Read moreRead less
Development of High Performance Nanocomposite Filtration Membranes: Fabrication and Fouling Mechanisms. This project will develop high performance membranes for the filtration of water and wastewater using novel nanotechnology processes. This will reduce the costs and environmental impact of water treatment and risk from low-level chemical contaminants such as micropollutants. The project will also provide an enhanced technology base for producing low cost, hybrid inorganic-organic materials fo ....Development of High Performance Nanocomposite Filtration Membranes: Fabrication and Fouling Mechanisms. This project will develop high performance membranes for the filtration of water and wastewater using novel nanotechnology processes. This will reduce the costs and environmental impact of water treatment and risk from low-level chemical contaminants such as micropollutants. The project will also provide an enhanced technology base for producing low cost, hybrid inorganic-organic materials for widespread environmental, agricultural and food applications.Read moreRead less
Periodic nano-ratchets: a new paradigm for biomolecule separation. This project proposes the theoretical and experimental study of a new separation principle. The platform technologies developed from this research will see wide ranging applications. They will reveal new insights into fundamental phenomena of membranes and separation processes underpinning development of new generation of separation technologies. New membranes and microchip separation devices which can be applied to genomic, prot ....Periodic nano-ratchets: a new paradigm for biomolecule separation. This project proposes the theoretical and experimental study of a new separation principle. The platform technologies developed from this research will see wide ranging applications. They will reveal new insights into fundamental phenomena of membranes and separation processes underpinning development of new generation of separation technologies. New membranes and microchip separation devices which can be applied to genomic, proteomic, forensic and a range medical, biotechnological and analytical applications will be readily achievable. This is an international and interdisciplinary research project and its outcomes will enhance Australia's ability in frontier technologies, advanced materials.Read moreRead less
Nanogels: Next Generation Polymeric Particles. The existing knowledge in the formation of polymeric networks limits the technological development of polymer materials. This project will introduce new polymeric particles, called nanogels to open a new area in new polymeric architecture research. A number of new structures based on the nanogels will be developed. These new macromolecules will not only bring the polymer science into a new field, it will provide a great opportunity to discover the ....Nanogels: Next Generation Polymeric Particles. The existing knowledge in the formation of polymeric networks limits the technological development of polymer materials. This project will introduce new polymeric particles, called nanogels to open a new area in new polymeric architecture research. A number of new structures based on the nanogels will be developed. These new macromolecules will not only bring the polymer science into a new field, it will provide a great opportunity to discover the next generation of the polymeric products, particularly for application in automotive paint, drug delivery and bio-molecular separations.Read moreRead less
Optimising Fouling Control in Membrane Bioreactors. Membrane bioreactors (MBR) are growing in importance for wastewater treatment because they offer an alternative for producing higher effluent quality wastewater within a more compact space compared to conventional processes. However, due to the pumping and bubbling used to keep the membranes clear of foulants resulting from the biological processes in MBR's, controlling fouling incurs significant energy usage and costs. The proposal aims to red ....Optimising Fouling Control in Membrane Bioreactors. Membrane bioreactors (MBR) are growing in importance for wastewater treatment because they offer an alternative for producing higher effluent quality wastewater within a more compact space compared to conventional processes. However, due to the pumping and bubbling used to keep the membranes clear of foulants resulting from the biological processes in MBR's, controlling fouling incurs significant energy usage and costs. The proposal aims to reduce the costs of fouling control by understanding the optimal conditions to remove these depositions and improve the design of MBR modules, operating conditions and shear delivery in the membrane system.Read moreRead less
Macromolecular Fouling in Membrane Bioreactors. As the demands for domestic and industrial water increasing in Australia and overseas, membrane bioreactors (MBR) offer an alternative for producing higher effluent quality wastewater compared to conventional processes. However, aeration costs used to remove fouling deposits (which reduce the operating performance) need to be further minimised. The proposal aims to study fundamental mechanisms involve in the deposition of foulant components by usin ....Macromolecular Fouling in Membrane Bioreactors. As the demands for domestic and industrial water increasing in Australia and overseas, membrane bioreactors (MBR) offer an alternative for producing higher effluent quality wastewater compared to conventional processes. However, aeration costs used to remove fouling deposits (which reduce the operating performance) need to be further minimised. The proposal aims to study fundamental mechanisms involve in the deposition of foulant components by using model systems of polysaccharides, proteins and microbial cells and comparing these with real MBR systems. The effect of bubbling varied gas compositions (air/H2S ratios) a novel approach in this study will be investigated to prevent or remove foulants in MBR systems. Read moreRead less
Multicomponent Transport in Nanopores. Good understanding of transport mechanisms in nanopores is crucial to the successful application of numerous recently developed novel templated microporous and mesoporous materials. This project seeks to extend a new theory developed by the applicants for single component transport in cylindrical mesopores, to cylindrical micropores as well as to multicomponent adsorbates, in conjunction with experiments using microporous and mesoporous materials such as M ....Multicomponent Transport in Nanopores. Good understanding of transport mechanisms in nanopores is crucial to the successful application of numerous recently developed novel templated microporous and mesoporous materials. This project seeks to extend a new theory developed by the applicants for single component transport in cylindrical mesopores, to cylindrical micropores as well as to multicomponent adsorbates, in conjunction with experiments using microporous and mesoporous materials such as MCM-41, VPI-5 and AlPO4-5. The outcome will be a powerful new theory for a priori prediction of transport coefficients for multicomponent fluids in nanopores based on molecular level information alone, thereby overcoming the empiricism in existing models.Read moreRead less
Developing high-flux ceramic membranes via in situ synthesis of metal oxide nanofibres for separations of biological substances. This project can deliver advanced technology for fabricating ceramic membranes and biological separation, which has considerable commercial prospects in the chemical, pharmaceutical, dairy, food and water industries. The new ceramic membrane and nanofibres are highly-valued end products of metal oxides, which are manufactured commercially on large scale in Australia. T ....Developing high-flux ceramic membranes via in situ synthesis of metal oxide nanofibres for separations of biological substances. This project can deliver advanced technology for fabricating ceramic membranes and biological separation, which has considerable commercial prospects in the chemical, pharmaceutical, dairy, food and water industries. The new ceramic membrane and nanofibres are highly-valued end products of metal oxides, which are manufactured commercially on large scale in Australia. The project could bring direct benefits to the existing industries, by fostering their growth into more value-added processes, and exporting highly-valued products abroad. Additionally, efficient ceramic membranes could offer solutions to the large-scale purification of biological substances and to the problems for providing clean drinking water.Read moreRead less