The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that dr ....The role of turgor in hyphal extension of the Ascomycete Neurospora crassa. Cellular expansion is an absolute necessity during the growth and development of plants and fungi. This process relies heavily upon the accumulation of inorganic ions. Osmotically driven water influx then creates the hydrostatic pressure that underlies the increase in cell volume. Cellular expansion is normally asymmetric and localised in one small region, such as hyphal tip. How does the cell maintain the turgor that drives expansion? How is expansion controlled spatially? These questions will be addressed in this project by comprehensive study of ion transport processes in a model organism, Neurospora crassa, using osmotic sensitive and transport mutants.Read moreRead less
A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Remotely sensed forest water use in space and time. Remotely sensed forest water use in space and time. This project aims to develop and apply new methods to scale forest water use from plot to catchment-level, using relationships between plot-level annual evapotranspiration and biophysical and biochemical properties of stands detectable by unmanned aircraft systems and other remote sensing platforms. Australia's water security depends on understanding how changes in forests from disturbance and ....Remotely sensed forest water use in space and time. Remotely sensed forest water use in space and time. This project aims to develop and apply new methods to scale forest water use from plot to catchment-level, using relationships between plot-level annual evapotranspiration and biophysical and biochemical properties of stands detectable by unmanned aircraft systems and other remote sensing platforms. Australia's water security depends on understanding how changes in forests from disturbance and climate change influence catchment water yields. This project will estimate water yields over time and space in ungauged catchments with disturbed eucalypt forests. This research is expected to enable more effective risk mitigation and planning for augmentations; improved fire management strategies; and better water management of the Murray Darling Basin.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100606
Funder
Australian Research Council
Funding Amount
$450,400.00
Summary
Effects of environmental change on seafood micronutrients: a SE Asian focus. This project aims to track variability in flows of essential micronutrients through marine food webs, to quantify how environmental changes will affect micronutrient supply to humans in seafood – findings that will be highly significant as governments grapple with increases in both malnutrition and ecological degradation. Expected outcomes: world-first models for accurately estimating nutrient production from SE Asian r ....Effects of environmental change on seafood micronutrients: a SE Asian focus. This project aims to track variability in flows of essential micronutrients through marine food webs, to quantify how environmental changes will affect micronutrient supply to humans in seafood – findings that will be highly significant as governments grapple with increases in both malnutrition and ecological degradation. Expected outcomes: world-first models for accurately estimating nutrient production from SE Asian reef fisheries up to 2050, under conditions of predicted climate change. Major expected benefits: new capacity to plan for food and nutrition security into an uncertain future, for Australia, our region, and beyond; with improvements to human nutrition and health, in accord with UN Sustainable Development Goal 2 (Zero Hunger).Read moreRead less
Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the ....Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the full productivity benefits of increased CO2 and when this will happen. This should improve predictions of carbon exchange and indicating the best direction for climate change adaptation measures.Read moreRead less
A novel top-down approach to ecosystem management using multivariate foraging strategies of an iconic marine top-predator. Understanding predator aggregation patterns in relation to marine productivity is critical in designing ecosystem-level conservation plans for protecting marine habitats and species. The project aims to develop a new approach to measure prey abundance and availability in the marine ecosystem for the management of resources of top-predators. This will be of specific benefit i ....A novel top-down approach to ecosystem management using multivariate foraging strategies of an iconic marine top-predator. Understanding predator aggregation patterns in relation to marine productivity is critical in designing ecosystem-level conservation plans for protecting marine habitats and species. The project aims to develop a new approach to measure prey abundance and availability in the marine ecosystem for the management of resources of top-predators. This will be of specific benefit in areas where a strong need exists for conservation of prey species with economic importance too low to justify expensive at-sea research.Read moreRead less
Effects of invasive macrofauna on marine biodiversity and ecosystem function. The project will identify environmental and biological factors that help prevent invasion of native marine communities by introduced pests, and describe thresholds in marine systems where further loss of macrofaunal species results in declines in ecosystem health.
Dynamic resilience and stability properties of marine systems: the importance of environment-engineer feedbacks in kelp forests. Kelp forests form complex habitats that support diverse, productive and economically important food-webs. This project will determine whether healthy kelp forests engineer their environment to make conditions more suitable for their continued recruitment and survivorship, thus increasing their stability and resilience in response to anthropogenic threats.
Taking advantage of rising CO2 to maximise ecosystem productivity. The rising atmospheric concentration of carbon dioxide provides an opportunity to increase ecosystem productivity, especially in agricultural systems. To what extent is highly uncertain, particularly when combined with changing temperature and precipitation. It has recently been demonstrated that seasonal water supply is the strongest controller of the productivity response to high carbon dioxide concentrations of grasslands. Th ....Taking advantage of rising CO2 to maximise ecosystem productivity. The rising atmospheric concentration of carbon dioxide provides an opportunity to increase ecosystem productivity, especially in agricultural systems. To what extent is highly uncertain, particularly when combined with changing temperature and precipitation. It has recently been demonstrated that seasonal water supply is the strongest controller of the productivity response to high carbon dioxide concentrations of grasslands. This project aims to elucidate the processes governing this response and develop simple models that could allow the conditions required to maximise the productivity benefit from rising carbon dioxide concentration to be calculated.Read moreRead less