Pore Engineering of Chromatography Membranes for Bioseparation. Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and technique ....Pore Engineering of Chromatography Membranes for Bioseparation. Protein separation and purification is an essential unit operation in manufacturing processes of therapeutic proteins. The project aims to advance the practical applications of chromatography membrane, an emerging technology for protein separation and purification, by tailoring membrane pore geometry and surface functionality to achieve enhanced separation performance. The project expects to generate advanced knowledge and techniques in the fields of reactive polymer synthesis, functional membrane fabrication and application in bioseparation. The innovative membranes developed in the project are able to improve the production capacity of therapeutic protein manufacturing processes, providing significant economic benefits to Australia.Read moreRead less
Carbon Molecular Sieve Membranes for Organic Solvent Separation. Directly addressing the pressing challenge of organic solvent separation faced by numerous industries, the project aims to develop molecular sieve membranes with outstanding selectivity and solvent tolerance by constructing zeolite-carbon mixed matrix membrane via incorporating zeolite nanosheets into carbon materials. The project expects to generate advanced knowledge of nanosheet synthesis, membrane fabrication and selective mole ....Carbon Molecular Sieve Membranes for Organic Solvent Separation. Directly addressing the pressing challenge of organic solvent separation faced by numerous industries, the project aims to develop molecular sieve membranes with outstanding selectivity and solvent tolerance by constructing zeolite-carbon mixed matrix membrane via incorporating zeolite nanosheets into carbon materials. The project expects to generate advanced knowledge of nanosheet synthesis, membrane fabrication and selective molecule transport. The membranes developed in the project have great potentials for improving the production capacity and sustainability of Australian industries, e.g., pharmaceutical manufacturing, bioethanol production and petroleum refining, providing significant economic and environmental benefits to Australia.Read moreRead less
Crystal engineering of membranes for chiral separation . This project addresses the urgent challenge of chiral separation in the manufacturing of pharmaceuticals and agrochemicals by creating a new class of membranes produced by engineering functionalised porous framework crystals. This project expects to generate new knowledge regarding how membrane chemistry and architecture can be used to achieve highly selective, fast chiral molecule transport. The expected outcomes of the project include ne ....Crystal engineering of membranes for chiral separation . This project addresses the urgent challenge of chiral separation in the manufacturing of pharmaceuticals and agrochemicals by creating a new class of membranes produced by engineering functionalised porous framework crystals. This project expects to generate new knowledge regarding how membrane chemistry and architecture can be used to achieve highly selective, fast chiral molecule transport. The expected outcomes of the project include new membrane compositions, design principles, fabrication techniques, and proof-of-concept production of scalable, high-performance composite membranes. This project should produce significant economic and environmental benefits in the development of advanced membranes, pharmaceuticals, and agrochemicals.Read moreRead less
A microfluidic approach to study the mechanobiology of ageing blood vessels. This project aims to study the effect of the stiffening of ageing arteries in endothelial cells. It explores the changes that occur in endothelial cells using a unique microfluidic technology with tuneable wall stiffness to mimic the biophysical and biochemical properties of ageing arteries. The expected outcome is the identification of the cellular mechanisms that control endothelial responses to arterial stiffening. T ....A microfluidic approach to study the mechanobiology of ageing blood vessels. This project aims to study the effect of the stiffening of ageing arteries in endothelial cells. It explores the changes that occur in endothelial cells using a unique microfluidic technology with tuneable wall stiffness to mimic the biophysical and biochemical properties of ageing arteries. The expected outcome is the identification of the cellular mechanisms that control endothelial responses to arterial stiffening. This should provide the fundamental knowledge required to assist in the development of new therapies to tackle age-related conditions such as cardiovascular disease and dementia.Read moreRead less
The molecular basis for efficacy at G protein coupled receptors. This project aims to investigate the molecular steps underlying the relationship between sensing by signal-transmitting proteins on the cell surface called G protein-coupled receptors and cellular response. The project aims to build on studies that have sought to understand the primary, molecular basis for this cellular volume control. This project seeks to use these novel approaches to fill this knowledge gap, providing a deeper u ....The molecular basis for efficacy at G protein coupled receptors. This project aims to investigate the molecular steps underlying the relationship between sensing by signal-transmitting proteins on the cell surface called G protein-coupled receptors and cellular response. The project aims to build on studies that have sought to understand the primary, molecular basis for this cellular volume control. This project seeks to use these novel approaches to fill this knowledge gap, providing a deeper understanding of how physiology and medicines work. The project expects to expand fundamental understanding of signal transmission at this receptor class. This project will deliver benefits including expanded basic knowledge and a contribution to future improvements in drug development.Read moreRead less
Function and evolution of insect odorant receptors. This project aims to shed light on how insect odorant receptors function by using comparative genomic studies between the genetic model insect Drosophila melanogaster and a pest species, the Australian sheep blowfly. This project expects to generate knowledge of how specific chemicals activate specific receptors in order to excite sensory neurons and drive behaviour, which is not well understood. Expected outcomes include increased understandin ....Function and evolution of insect odorant receptors. This project aims to shed light on how insect odorant receptors function by using comparative genomic studies between the genetic model insect Drosophila melanogaster and a pest species, the Australian sheep blowfly. This project expects to generate knowledge of how specific chemicals activate specific receptors in order to excite sensory neurons and drive behaviour, which is not well understood. Expected outcomes include increased understanding of olfaction in insects, increased national and international collaboration, and outstanding graduate student training. This research will be of significant future benefit in deriving methods to modify the behaviour of insects of agricultural or medical importance, for example the sheep blowfly. Read moreRead less
Advanced separators for lithium-sulphur batteries. This project aims to develop new membranes for use as separators in lithium-sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, ....Advanced separators for lithium-sulphur batteries. This project aims to develop new membranes for use as separators in lithium-sulphur batteries. Currently diffusion of polysulphides within these batteries reduces battery power and lifetime. The new membranes are intended to block polysulphide diffusion over an extended lifetime, while transporting the other ions needed for the battery to function. The project is expected to generate new membrane materials and further knowledge about the design, synthesis and larger-scale production of membranes for electrochemical applications. This project will provide significant benefits by producing potentially lighter, longer-lasting and cheaper batteries than existing lithium-ion technologies, with the potential to accelerate the adoption of electric cars.Read moreRead less
Discovering novel allosteric probes of muscarinic acetylcholine receptors. This project aims at fostering novel approaches to selectively target vital receptors in the human body, the muscarinic acetylcholine receptors (mAChRs). By harnessing the design of receptor mutations, compounds synthesis and fluorescent imaging, the project expects to develop new pharmacological tools for a family of receptors essential for the life of all vertebrates. By enriching our understanding of this family of rec ....Discovering novel allosteric probes of muscarinic acetylcholine receptors. This project aims at fostering novel approaches to selectively target vital receptors in the human body, the muscarinic acetylcholine receptors (mAChRs). By harnessing the design of receptor mutations, compounds synthesis and fluorescent imaging, the project expects to develop new pharmacological tools for a family of receptors essential for the life of all vertebrates. By enriching our understanding of this family of receptor, the project expects to provide significant benefits to the research field by impacting on future drug discovery efforts, not only at mAChRs, but at other structurally related receptors.Read moreRead less
A novel axis of cooperation between innate and adaptive immunity. The project aims to understand how two molecular components of the immune system, Complement and MHC, cooperate to protect the host. Further, these two molecules mediate trogocytosis, a little-studied form of intercellular communication, between two major immune cell types: dendritic cells and B cells. The project will be multidisciplinary, applying high-end microscopy, biochemistry, cell biology and immunology techniques. Person ....A novel axis of cooperation between innate and adaptive immunity. The project aims to understand how two molecular components of the immune system, Complement and MHC, cooperate to protect the host. Further, these two molecules mediate trogocytosis, a little-studied form of intercellular communication, between two major immune cell types: dendritic cells and B cells. The project will be multidisciplinary, applying high-end microscopy, biochemistry, cell biology and immunology techniques. Personnel will be trained in cutting-edge techniques. The project will expand knowledge on basic immunology and cell-cell cooperation. It will generate intellectual property for the biotechnology sector to develop new commercial products that might improve the health of humans and also animals of economic importance.Read moreRead less
Epitaxial Stacking of Nanoporous Nanosheets for Next-generation Membranes. The project aims to develop high-precision selective membranes which are urgently needed in Australian key industries for solute-solute separation by constructing vertically-aligned and chemically-tailorable nanochannels using two-dimensional porous nanosheets as building blocks. The project expects to generate advanced knowledge in the areas of nanosheet synthesis and functionalisation, membrane design and fabrication, s ....Epitaxial Stacking of Nanoporous Nanosheets for Next-generation Membranes. The project aims to develop high-precision selective membranes which are urgently needed in Australian key industries for solute-solute separation by constructing vertically-aligned and chemically-tailorable nanochannels using two-dimensional porous nanosheets as building blocks. The project expects to generate advanced knowledge in the areas of nanosheet synthesis and functionalisation, membrane design and fabrication, selective transport of solutes and applications. The membranes developed in the project should make existing separation processes more effective and sustainable and advance emerging applications in pharmaceutical, dairy and mining industries, providing significant economic and environmental benefits to Australia.Read moreRead less