Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Methane Coupling Using Mixed Conducting Catalytic Ceramic Hollow Fibre Membrane Reactor. The Gas product industry is one of the most important economic sectors in Australia, employing 10000 people with market value of $ 100 billion per year from power generation and LNG export. However, there are increasing concerns over issues of the green house gases emission and petroleum dwindling. This project addresses the technology needs in converting natural gas to more useful chemicals via a more effic ....Methane Coupling Using Mixed Conducting Catalytic Ceramic Hollow Fibre Membrane Reactor. The Gas product industry is one of the most important economic sectors in Australia, employing 10000 people with market value of $ 100 billion per year from power generation and LNG export. However, there are increasing concerns over issues of the green house gases emission and petroleum dwindling. This project addresses the technology needs in converting natural gas to more useful chemicals via a more efficient and cleaner means of methane utilization. The project target is to make the natural gas resources in Australia to delivery high value products with considerable economic benefits and increased employment opportunities. Read moreRead less
Preparing Carbon Molecular Sieve Membrane (CMSM) for Olefin/Paraffin Separation. Carbon molecular sieve membrane (CMSM) presents superior selectivity and stability for many gas separation processes. This technology is energy saving, environmental friendly and with minimal operating cost. The project will develop CMSMs for the separation of olefin/paraffin, particularly, the propane/propylene mixture which is currently separated by the energy intensive cryogenic distillation in industry. The pro ....Preparing Carbon Molecular Sieve Membrane (CMSM) for Olefin/Paraffin Separation. Carbon molecular sieve membrane (CMSM) presents superior selectivity and stability for many gas separation processes. This technology is energy saving, environmental friendly and with minimal operating cost. The project will develop CMSMs for the separation of olefin/paraffin, particularly, the propane/propylene mixture which is currently separated by the energy intensive cryogenic distillation in industry. The project involves both experimental works and theoretical studies and will provide: (1) techniques for preparing CMSMs for olefin/paraffin separation; (2) methods characterizing the micro-structure of CMSMs; (3) mathematical models predicting multicomponent gas permeation/separation properties on CMSMs; (4) effect of impurities on the separation processes. Read moreRead less
Perovskite Asymmetric Hollow Fibres for Oxygen Separation in Clean Coal Energy Delivery. The coal industry is one of the most important economic sectors in Australia, employing 30000 people, whilst black coal is Australia's largest export worth around $24.5 billion. Energy security of supply is critical to Australia's social stability and economic growth, though Australia's reliance on coal for energy delivery is under strong scrutiny due to carbon mitigation. This project addresses the technolo ....Perovskite Asymmetric Hollow Fibres for Oxygen Separation in Clean Coal Energy Delivery. The coal industry is one of the most important economic sectors in Australia, employing 30000 people, whilst black coal is Australia's largest export worth around $24.5 billion. Energy security of supply is critical to Australia's social stability and economic growth, though Australia's reliance on coal for energy delivery is under strong scrutiny due to carbon mitigation. This project addresses the technology needs in tonnage oxygen separation towards a more efficient and cleaner means of generating energy. The project's benefits target at providing Australian consumers with affordable electricity in a decarbonised economy, enabling clean coal energy delivery to underpin the international competitiveness of the entire Australian economy.Read moreRead less
The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magneto ....The role of mechanosensitive (MS) ion channels in magnetoreception. The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. Based on our preliminary investigations, which suggest that the activity of bacterial MS channels may be affected by magnetic fields, we propose to study effects of magnetic fields on MS ion channels in Gram-negative bacteria Escherichia coli and Magnetospirillum magnetotacticum. The project promises also to contribute towards better understanding of adverse effects of electromagnetic radiation on human health and towards understanding the mechanisms behind remote magnetic-nanoparticle mediated activation of MS ion channels.Read moreRead less
Monolayer crystallization of membrane proteins. Membrane proteins comprise 25-40% of all proteins and conduct a myriad of finely tuned reactions in every cell. Despite their importance and diversity only ~40 membrane protein structures have been solved, due to the difficulty of producing high quality 2D and 3D crystals. We propose to develop and use the new monolayer crystallization technique, which employs a lipid monolayer as a crystallization template for 2D crystal production. A number of ....Monolayer crystallization of membrane proteins. Membrane proteins comprise 25-40% of all proteins and conduct a myriad of finely tuned reactions in every cell. Despite their importance and diversity only ~40 membrane protein structures have been solved, due to the difficulty of producing high quality 2D and 3D crystals. We propose to develop and use the new monolayer crystallization technique, which employs a lipid monolayer as a crystallization template for 2D crystal production. A number of important membrane proteins are available for these structural studies including ABC transporters, Caveolin-3 and the NS1 protein of Dengue virus, all of which are difficult to crystallize using conventional techniques.Read moreRead less
Carbon Molecular Sieve Membranes for Organic Solvent Separation. Directly addressing the pressing challenge of organic solvent separation faced by numerous industries, the project aims to develop molecular sieve membranes with outstanding selectivity and solvent tolerance by constructing zeolite-carbon mixed matrix membrane via incorporating zeolite nanosheets into carbon materials. The project expects to generate advanced knowledge of nanosheet synthesis, membrane fabrication and selective mole ....Carbon Molecular Sieve Membranes for Organic Solvent Separation. Directly addressing the pressing challenge of organic solvent separation faced by numerous industries, the project aims to develop molecular sieve membranes with outstanding selectivity and solvent tolerance by constructing zeolite-carbon mixed matrix membrane via incorporating zeolite nanosheets into carbon materials. The project expects to generate advanced knowledge of nanosheet synthesis, membrane fabrication and selective molecule transport. The membranes developed in the project have great potentials for improving the production capacity and sustainability of Australian industries, e.g., pharmaceutical manufacturing, bioethanol production and petroleum refining, providing significant economic and environmental benefits to Australia.Read moreRead less
Subunit stoichiometry and arrangement in the glycine receptor. Glycine receptors are important for nervous system function. These receptors comprise a mixture of 5 alpha and beta subunits arranged around a central ion-conducting pore. The subunit stoichiometry (i.e., numbers of alpha and beta subunits) and arrangement (i.e., subunit order) are unknown. The first aim of this project is to define these parameters using tethered subunits. The second aim is to use the tethered subunits to probe th ....Subunit stoichiometry and arrangement in the glycine receptor. Glycine receptors are important for nervous system function. These receptors comprise a mixture of 5 alpha and beta subunits arranged around a central ion-conducting pore. The subunit stoichiometry (i.e., numbers of alpha and beta subunits) and arrangement (i.e., subunit order) are unknown. The first aim of this project is to define these parameters using tethered subunits. The second aim is to use the tethered subunits to probe the structure and function of glycine and zinc binding sites at an unprecedented level of resolution. The results will provide crucial new information concerning glycine receptor structure and function.Read moreRead less
Fundamental Characterization of Adsorption of Simple to Complex Fluids on Carbon Black and in Carbon Pores. The outcome of this project will help designing engineers with a molecular simulation model for adsorption of simple to complex fluids commonly used in industries. The success of this project translates to a significant saving because it requires minimum effort in experimentation.
Methane hydrate in carbon nanopores as a potential means for energy storage. This project deals with the innovative means to store methane (natural gas) in the form of methane hydrate in the nanospace of carbon pores. The significance of this project lies in the enhanced storage of methane at a moderate pressure, compared to the compressed natural gas technology. Expected outcome is the better and efficient utilization of natural gas in transportation industries, and the better understanding o ....Methane hydrate in carbon nanopores as a potential means for energy storage. This project deals with the innovative means to store methane (natural gas) in the form of methane hydrate in the nanospace of carbon pores. The significance of this project lies in the enhanced storage of methane at a moderate pressure, compared to the compressed natural gas technology. Expected outcome is the better and efficient utilization of natural gas in transportation industries, and the better understanding of the formation of methane hydrate in carbon nanopores.Read moreRead less