In 2013 there were ~200 million clinical cases of malaria, causing ~600,000 deaths. All antimalarial drugs are now associated with malaria parasite resistance. Thus, new therapies are urgently needed, including new drugs to prevent this disease. We have made the exciting discovery that an existing antimalarial drug can kill malaria parasites in a unique, previously unknown, manner. Here, we will investigate how this occurs and develop new drug candidates for malaria prevention.
Does Australian Corporate Taxation Matter? On a GDP-weighted basis the average OECD corporate rate has fallen from 44 percent in 1985 to 31 percent in 2004. Australia operates a flat thirty percent corporate tax rate and this compares well with the current OECD average. Yet, the Business Council of Australia argues that the Australian corporate tax rate is 'uncompetitive'. Certainly, the corporate tax burden (i.e. corporate tax revenue as a proportion of GDP) is very high in Australia, the thi ....Does Australian Corporate Taxation Matter? On a GDP-weighted basis the average OECD corporate rate has fallen from 44 percent in 1985 to 31 percent in 2004. Australia operates a flat thirty percent corporate tax rate and this compares well with the current OECD average. Yet, the Business Council of Australia argues that the Australian corporate tax rate is 'uncompetitive'. Certainly, the corporate tax burden (i.e. corporate tax revenue as a proportion of GDP) is very high in Australia, the third highest in the OECD, and the highest in the Asia-Pacific region. This project will evaluate the extent that the corporate tax burden is a hinderance to Australian firms and economic behaviour. Read moreRead less
Effects on Labour Supply, Savings and Welfare of the July 2007 Policy Changes to Superannuation and the Age Pension. This proposal's central question falls within the priority goal of 'Strengthening Australia's social and economic fabric'. Understanding the effects of alternative superannuation tax arrangements is crucial in view of concerns regarding aggregate private savings and labour force participation in an ageing economy. Low savings or participation could have implications for sustained ....Effects on Labour Supply, Savings and Welfare of the July 2007 Policy Changes to Superannuation and the Age Pension. This proposal's central question falls within the priority goal of 'Strengthening Australia's social and economic fabric'. Understanding the effects of alternative superannuation tax arrangements is crucial in view of concerns regarding aggregate private savings and labour force participation in an ageing economy. Low savings or participation could have implications for sustained economic growth. This project's outcomes will provide an indication of the potential effects of policies on labour supply and savings. After further modifications, the model developed in this project can also address other questions in the context of life-cycle decisions under uncertainty, such as labour supply, fertility or health.Read moreRead less
The Role Of Presenilin In Metal Homeostasis And Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,335.00
Summary
Presenilin, a protein involved in Alzheimer’s disease (AD), may regulate copper and zinc levels. Copper and zinc are essential nutrients however a deficiency or excess can cause disease. Promising metal-altering AD drugs, are in various stages of clinical trial. I aim to characterize the interaction of Presenilin and metals using both mouse and cultured human cell models that are deficient in Presenilin. Understanding this interaction should lead to better drug design and treatment of AD.
Understanding How Bcl-2 Proteins Form The Apoptotic Pores That Kill Cells
Funder
National Health and Medical Research Council
Funding Amount
$893,614.00
Summary
Programmed cell death termed apoptosis is a process our bodies use to remove cells that are a threat to our health, e.g. cancer cells. The proteins that regulate cell death are attractive targets for therapeutics that have become resistant to this defence mechanism. This study will reveal how proteins from the Bcl-2 family regulate cell death at the molecular level. Understanding this process will inform the development of drugs aimed at regulating cell death in cancer and other diseases.
What Is The Molecular Mechanism Underlying Cell Death By Necroptosis?
Funder
National Health and Medical Research Council
Funding Amount
$653,742.00
Summary
Recently, we and others have demonstrated that part of the MLKL protein is able to kill cells. This process is known to cause a number of pathologies, including those arising from stroke. Blocking this type of cell death has thus emerged as an attractive therapeutic strategy. However, precisely how MLKL kills cells remains unclear and controversial. In this project, we will resolve these controversies with the goal of an increased fundamental understanding to aid drug discovery.
Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement i ....Managing an ageing population for income adequacy and fiscal sustainability. This project aims to improve understanding of the impacts of existing key reforms intended to ease fiscal pressures associated with population ageing. The right mix of retirement income policies is vital to Australia's fiscal sustainability, however the effectiveness of existing policies is unknown. The project expects to identify impacts of key reforms on employment, re-training, income, savings and future retirement income and public pension receipt. The project will develop a new tax records-based dataset to facilitate future research on tax and welfare systems.Read moreRead less
The Effective Treatment of Hot Dip Galvanizing Effluent Streams. Hot Dip galvanizing effluent represents a significant environmental hazard. This wastewater is currently trucked offsite and treated by contractors to precipitate a heavy metal sludge that is disposed of through landfill. Industrial Galvanisers, as the largest hot dip galvanizing company within Australia, are keen to eliminate this hazard. We will consider the use of an innovative membrane based process for this purpose; to recover ....The Effective Treatment of Hot Dip Galvanizing Effluent Streams. Hot Dip galvanizing effluent represents a significant environmental hazard. This wastewater is currently trucked offsite and treated by contractors to precipitate a heavy metal sludge that is disposed of through landfill. Industrial Galvanisers, as the largest hot dip galvanizing company within Australia, are keen to eliminate this hazard. We will consider the use of an innovative membrane based process for this purpose; to recover valuable zinc and iron compounds from the effluent and allow the water to be re-utilised. If successful, this project will lead to a pilot plant wastewater treatment plant being constructed at an Industrial Galvanizers site.Read moreRead less
The Treatment Of Galvanizing Wastewater: Delivering An Environmentally And Economically Sustainable Approach. This project will investigate a process to treat wastewater from industrial galvanizing sites around Australia. When implemented, the process will substantially reduce the consumption of acid and fresh water at these sites. Further, the process will recover the zinc content of the wastewater in a saleable form and can also generate ferric chloride for sale as a water treatment chemical. ....The Treatment Of Galvanizing Wastewater: Delivering An Environmentally And Economically Sustainable Approach. This project will investigate a process to treat wastewater from industrial galvanizing sites around Australia. When implemented, the process will substantially reduce the consumption of acid and fresh water at these sites. Further, the process will recover the zinc content of the wastewater in a saleable form and can also generate ferric chloride for sale as a water treatment chemical. The quantity of heavy metals disposed to landfill will also be dramatically reduced. Scientific knowledge of multicomponent liquid-liquid equilibria will be of value to a wider range of solvent extraction processes including zinc and copper metal refining.Read moreRead less
Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for ....Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for heterogeneity in treatment responses, and the findings will be combined with a study of regulatory and administrative processes to support the ultimate goal of a legitimate, fair, cost-effective and responsive tax system.Read moreRead less