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The Development Of Selective And Potent Kv1.3 Ion Channel Blockers For The Treatment Of Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$233,187.00
Summary
Building on the well-established path of developing drugs from Nature, the amplification of some unusual qualities of a naturally-occurring substance, khellinone, could lead to new treatments for autoimmune diseases such as multiple sclerosis and diabetes. Designed variants of khellinone are known to be very effective at preventing the destructive impact of the body's own T cells on the central nervous system that occurs in autoimmune disease.
Development Of A Self-adjuvanting Mucosal Vaccine Candidate Against Group A Streptococcus Using Lipid Core Technology
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Novel developments in drug/vaccine delivery are clearly to have enormous economic and social impacts. My research aim is to rationally design and develop vaccines against relevant diseases. By understanding the mechanism of protection against diseases, development of novel vaccines for the treatment of many diseases can be achieved. This would contribute enormously to the betterment of public health.
Isolation And Pre-clinical Evaluation Of Small Molecule Anti-inflammatory Compounds From Hookworms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
This project will harness the unique ability of hookworm small molecules (<10 kDa) to modulate inflammation, and exploit these properties to develop novel modalities to treat inflammatory bowel diseases, using millennia of host-parasite coevolution as a guide. The excretory/secretory and somatic extracts will be assessed for their anti-inflammatory properties using TNBS mouse model. Compounds will be separated using HPLC and identified using MS and NMR spectroscopy.
Chemical Aided Phospoproteome Sequencing With Mass Spectrometry
Funder
National Health and Medical Research Council
Funding Amount
$141,000.00
Summary
Essentially all of the body's functions from muscle contraction, energy expenditure through to appetite are controlled by a complex molecular communications system. One of the key elements involves the modification of proteins to alter their properties by adding and removing phosphate. By analysing this process in response to diet and exercise we will obtain a greater understanding of their health benefits and understand how type 2 diabetes and obesity develop at the molecular level.
A New Approach To Explore The Role Of Selenoproteins In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$374,284.00
Summary
Selenoproteins play an important role in a variety of major diseases. Yet knowledge of the biology of selenium and its role in disease prevention and progression is not sufficient to recommend selenium supplementation for disease prevention or treatment. The broad aim of this research is to identify and characterise the response of selenoproteins to selenium supplementation and disease states.
Disarming Deadly Viruses: High Throughput Protease Screening Using Massive Peptide Libraries
Funder
National Health and Medical Research Council
Funding Amount
$405,625.00
Summary
Viral diseases affect millions of people worldwide with mortality rates as high as 50%. Viral enzymes help liberate proteins essential for viral replication. The rapid identification of the activity and specificity of these viral enzymes is important to combat outbreaks of viral disease and has become possible through biomedical device technology developed by the industry partner. With just 17 new drugs approved by the FDA in 2002, the proposed program has the potential to deliver new drugs quic ....Viral diseases affect millions of people worldwide with mortality rates as high as 50%. Viral enzymes help liberate proteins essential for viral replication. The rapid identification of the activity and specificity of these viral enzymes is important to combat outbreaks of viral disease and has become possible through biomedical device technology developed by the industry partner. With just 17 new drugs approved by the FDA in 2002, the proposed program has the potential to deliver new drugs quickly and efficiently, and this will be of benefit to viral disease sufferers worldwide.Read moreRead less
Translating A Drop Of Blood Into Effective Antibiotic Dosing In Infants And Children
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The optimal use of currently available antibiotics is of utmost importance at a time when few new antibiotics are being developed and there is a continued emergence of antibiotic resistant ‘superbugs’. This Fellowship will establish evidence-based, effective antibiotic dosing regimens for children with severe infection - using just a drop of blood. By applying innovation in microsampling, my research will advance our treatment of infection and result in better outcomes for sick children.
An Exploration Of The Interface Between Indigenous Knowledge And Anti-cancer Potential Of Traditionally Used Plants.
Funder
National Health and Medical Research Council
Funding Amount
$308,954.00
Summary
This research is directed towards embedding a model that enables the integration of Indigenous and Western-scientific knowledge of medicinal plants with anti-cancer properties or desirable bioactivities which may be associated with relieving the side effects of cancer treatment. Improved relationship and capacity building will be achieved through social engagement activties between Indigenous and Western researchers by teaching scientific related skills and knowledge related to practices conduct ....This research is directed towards embedding a model that enables the integration of Indigenous and Western-scientific knowledge of medicinal plants with anti-cancer properties or desirable bioactivities which may be associated with relieving the side effects of cancer treatment. Improved relationship and capacity building will be achieved through social engagement activties between Indigenous and Western researchers by teaching scientific related skills and knowledge related to practices conducted on traditional homelands.Read moreRead less
Design And Evaluation Of Inhibitors Targeting Serine Proteases In Blood To Alleviate Systemic Inflammatory Response To Coronary Artery Bypass Graft Surgery
Funder
National Health and Medical Research Council
Funding Amount
$317,559.00
Summary
Over 20,000 Australians undergo bypass surgery each year with a 3% mortality rate linked to complications from the procedure. One such common complication is caused by the body’s immune system being activated when the blood comes in contact with the blood bypass pump machine. This project aims to develop new medicines to block this activation of the immune system during bypass surgery to reduce complications and mortality associated with this procedure.
Venoms To Drugs: Characterizing The Molecular Interactions Between Venom Peptides And Ion Channels With A View To Rational Drug Design
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
The conventional approach to drug development is reaching a state of crisis as it is producing fewer new drugs at increasing cost. A promising alternative is to harness the rich and diverse chemistry of venom peptides. This project aims to understand the mechanism by which venom peptides achieve their pharmacological activity. This knowledge is essential for venom-based drug design for treating diseases ranging from nervous systems disorders, stroke, chronic pain and psychiatric illnesses.