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The Development Of A Loop-mediated Isothermal Amplification (LAMP) Assay For The Detection Of Strongyloides Stercoralis In The Stool.
Funder
National Health and Medical Research Council
Funding Amount
$127,494.00
Summary
A new test will be developed for the detection of the worm, Strongyloides stercoralis in the stool. S. stercoralis infects millions of people worldwide and occurs in the north of Australia. It can occasionally cause a ‘hyperinfection’ with fatal consequences. The test is based on the DNA detection method, loop-mediated isothermal amplification (LAMP), which can be performed using simple equipment. The aim will be to make this test as easy possible to perform and to evaluate its effectiveness.
In Vitro And In Vivo Investigation Of Actin Regulation In The Malaria Parasite
Funder
National Health and Medical Research Council
Funding Amount
$92,294.00
Summary
Malaria parasites move in a unique way. They move across cell surfaces and infect human cells using a unique molecular motor that allows them to, literally, glide. The research proposal outlined here is focused on understanding a key part of the motor – the dynamic protein actin – and by understanding how it is regulated develop new potential targets for novel drugs that might stop movement and, therefore, help prevent or treat malaria disease.
Anatomy, Epidemiology And Aetiology Of Tricuspid Valve Disease And Its Impact On The Development Of Emerging Transcatheter Therapies
Funder
National Health and Medical Research Council
Funding Amount
$88,662.00
Summary
Tricuspid valve disease is common, associated with poor prognosis and has few available treatment options. The aim of this project is to improve our understanding of the burden of tricuspid valve disease, and the factors that drive its occurrence and progression. We also aim to improve our practice of pacemaker/defibrillator insertion (which can injury the tricuspid valve). Our investigations will help inform improvement in the treatment of this condition, including minimally invasive options.
For Every Question, There Is An Answer: Application Of Genomic Sequencing And Functional Genomics For Disease Gene Discovery In Children With Orphan Phenotypes
Funder
National Health and Medical Research Council
Funding Amount
$99,682.00
Summary
My PhD study will look closely at the genes in a family to see what is different and whether this difference is the cause of rare health problems. I will focus on children with highly unique conditions in which intellectual disability/developmental delay is a key feature. My study is important because if I can find the exact cause of rare genetic conditions, then I hope to improve the welfare of patients and families affected by these types of conditions.
Feasibility Of Using Pre-hospital Point-of-care Troponin And Paramedic Risk Assessment In Patients With Chest Pain Without ST-elevation
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
Non-traumatic chest pain is the leading cause of ambulance services use in Victoria. Currently, there is no protocol for paramedics to determine which patients are high risk and suffering a minor heart attack, which results in delays in treatment. The aim of this project is to assess the feasibility of a risk assessment tool, including the use of point-of-care blood testing to detect heart attacks, to accurately risk stratify chest pain patients in the pre-hospital setting.
Out-of-hospital cardiac arrest is fatal without immediate resuscitation. Paramedic competency in resuscitation has been shown to influence cardiac arrest survival. Through my doctoral research I aim to investigate: how paramedic exposure to cardiac arrest can influence patient survival; the practices emergency medical services currently use to develop and maintain paramedic competency in resuscitation; and the confidence and perceived competency of paramedics responding to cardiac arrests.
Personalised Treatment In Melanoma: Matching Optimal Drug Therapies For Individual Patients To Improve Survival.
Funder
National Health and Medical Research Council
Funding Amount
$132,743.00
Summary
The best treatment for melanoma currently is immunotherapy. However, most patients become resistant to immunotherapy after an initial response. When this occurs, patients are treated with new medications, often in a clinical trial. Unfortunately, doctors cannot predict if a patient is going to respond to a particular new treatment. This project will study the makeup of individual melanomas and use this to recommend which new treatment is most likely to work for the patient.
Development, Validation And Implementation Of A Technical And Non-technical Skills Training Curriculum For Laparoscopic Appendicectomy Surgery
Funder
National Health and Medical Research Council
Funding Amount
$41,237.00
Summary
A structured training curriculum will be developed that can teach novice surgeons in key surgical and decision-making skills required for laparoscopic appendectomy surgery (key-hole removal of the appendix). An assessment tool that can quantitatively evaluate performance during a laparoscopic appendectomy will be developed. Using this, the ability of the developed training curriculum to improve the performance of trainee surgeons during actual laparoscopic appendectomy surgery will be evaluated.
Application Of Machine Learning Techniques To Disease Surveillance To Identify Risk Groups For Blood Borne Viruses And Sexually Transmissible Infections
Funder
National Health and Medical Research Council
Funding Amount
$76,365.00
Summary
Electronic medical records from general practice are used to provide clinically detailed disease surveillance data to inform public health decisions. Risk factor information is not systematically recorded making it difficult to identify risk groups using these data. This PhD will improve surveillance by applying new data science methods to de-identified electronic medical records from general practice to better identify risk groups for blood borne viruses and sexually transmissible infections.
Ambulance Demand: Random Events Or Predictable Patterns
Funder
National Health and Medical Research Council
Funding Amount
$59,191.00
Summary
Over the past 20 years there has been an increase in demand for emergency ambulance services across the developed world, placing significant strain on ambulance resources. However, it is not known if demand is constant across different times of day, days of the week or months of the year. This PhD will examine temporal patterns in ambulance demand using four years of data derived from paramedic assessment. Understanding these patterns will provide evidence to inform ambulance practice.