The Structure And Function Of The Apical Domain In Insulin Secreting Beta Cells.
Funder
National Health and Medical Research Council
Funding Amount
$571,741.00
Summary
Loss of control of insulin secretion is causal in diabetes and therefore its understanding is a key goal to shed light on the disease. We have recently identified a new domain in the insulin secreting cells, called the apical domain. This proposal will define the role of this apical domain in controlling insulin secretion. The outcomes could provide new insights into how diabetes develops and new targets for therapies.
Practicalism: Knowing and Agency. Australian philosophy has a deserved reputation for excellence, especially in topics of traditional centrality for analytic philosophers. But more still needs to be done within Australian epistemology. Most of the recent related work has occurred within the philosophies of mind, of language, and of science, and to some extent within ethics. That work needs to be complemented by good work in epistemology. I hope this project will help to achieve that, thereby inc ....Practicalism: Knowing and Agency. Australian philosophy has a deserved reputation for excellence, especially in topics of traditional centrality for analytic philosophers. But more still needs to be done within Australian epistemology. Most of the recent related work has occurred within the philosophies of mind, of language, and of science, and to some extent within ethics. That work needs to be complemented by good work in epistemology. I hope this project will help to achieve that, thereby increasing the national and international philosophical visibility of Australian epistemology.Read moreRead less
Examining The Metabolic And Cognitive Deficits Caused By Insulin Resistance In The Ventral Striatum
Funder
National Health and Medical Research Council
Funding Amount
$400,372.00
Summary
Brain insulin resistance is thought to cause metabolic and cognitive deficits, but the underlying neural mechanisms remain elusive. This project addresses this gap in our knowledge by examining how brain insulin resistance disrupts the metabolic regulation of food intake and the cognitive control of actions. The outcomes will provide new insights in disorders characterised by brain insulin resistance such as obesity and dementia.
Autonomy and Identity: A Relational Theory. Autonomy is widely regarded as an important value in liberal democratic societies and underpins many of the basic rights and legal protections enjoyed by citizens. The principle of respect for autonomy is a guiding ethical principle in a range of areas, including in medical and legal contexts, for example in requirements regarding informed consent, and in ethical guidelines governing protocols for research involving human subjects. A better understandi ....Autonomy and Identity: A Relational Theory. Autonomy is widely regarded as an important value in liberal democratic societies and underpins many of the basic rights and legal protections enjoyed by citizens. The principle of respect for autonomy is a guiding ethical principle in a range of areas, including in medical and legal contexts, for example in requirements regarding informed consent, and in ethical guidelines governing protocols for research involving human subjects. A better understanding of autonomy and its relationship to the social context has the potential to produce indirect socio-economic benefits by informing theory and practice in these and other areas. Read moreRead less
The structure and function of self-representation. Recent psychology and neuroscience suggests that human beings are very bad at knowing themselves. This project changes that debate by arguing that our self-examination is not designed to increase self-knowledge, but to help us navigate the social world.
Point of view in personal memory: a philosophical study of perspective in remembering and imagining. Remembering the personal past is a key part of mental life, vital for identity and social sharing as well as for tracking the truth: but why do we sometimes remember past events from an external or 'observer' perspective, seeing ourselves in the remembered scene? This project in philosophy of mind develops a new theory of psychological perspective.
Discovery Early Career Researcher Award - Grant ID: DE240100711
Funder
Australian Research Council
Funding Amount
$416,237.00
Summary
Understanding Psychological Impossibility. This project will develop the first account of psychological impossibility by combining philosophical theorizing with results from the cognitive and brain sciences, and experimental philosophy. Something is psychologically impossible when it is not available in our psychology as an option to choose. Through developing an account of psychological impossibility this project will advance our understanding of the nature of autonomy, free will and moral resp ....Understanding Psychological Impossibility. This project will develop the first account of psychological impossibility by combining philosophical theorizing with results from the cognitive and brain sciences, and experimental philosophy. Something is psychologically impossible when it is not available in our psychology as an option to choose. Through developing an account of psychological impossibility this project will advance our understanding of the nature of autonomy, free will and moral responsibility. It will also provide major benefits to policy makers and legal and health professionals by giving them the theoretical resources required for ethical decision making when dealing with people that have different affordances for choice and action.Read moreRead less
Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catal ....Reactivity and Spectroscopy of Gas Phase Metal Oxide Cluster Ions: Structure-Reactivity Correlations and Fundamental Insights into Heterogeneous Catalysis. This project will make use of world class ARC funded instrumentation to carry out breakthrough science. The research will contribute fundamental insights into chemical bond activation relevant to industrial catalytic processes important to national manufacturing industries. These insights will improve the efficiency and selectivity of catalytic processes and lead to increased profitability and/or a reduction in unwanted side products and pollution. The project will train young scientists in important experimental and theoretical chemical techniques, and will enhance and contribute to Australia's international research profile.Read moreRead less
Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new ....Trust and Distrust in Social Epistemic Networks. This project aims to discover critically-needed understandings of the social causes and consequences of ‘fake news’. It will do this by investigating and mapping the relationship between ‘epistemic vices’ and people’s acceptance of misinformation and disinformation (e.g. conspiracy theories). It will bring together approaches from experimental philosophy, natural language processing, social network analysis, and normative reflection to provide new insights regarding distrust and intellectual vice, thus significantly advancing knowledge of the ‘dark side’ of social epistemology. Results will lead to urgently required guidance regarding the features of social networks that exacerbate or buffer against the manifestation of these vices.Read moreRead less