Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Discovery Early Career Researcher Award - Grant ID: DE230101196
Funder
Australian Research Council
Funding Amount
$439,012.00
Summary
Data-Driven Design for 3D Printed Materials with Tailored Fracture Response. Fracture is the main source of material failure and may cause serious engineering disasters and even death. This project aims to develop a Data-Driven Design System that intelligently optimizes local materials and architectures for heterogeneous structures with desired fracture response, and enhancing their mechanical fracture properties including stiffness, strength, toughness, and failure displacement. It will open up ....Data-Driven Design for 3D Printed Materials with Tailored Fracture Response. Fracture is the main source of material failure and may cause serious engineering disasters and even death. This project aims to develop a Data-Driven Design System that intelligently optimizes local materials and architectures for heterogeneous structures with desired fracture response, and enhancing their mechanical fracture properties including stiffness, strength, toughness, and failure displacement. It will open up a new and promising research field in mechanics and data-driven science that deals with intractable inverse problems in broad engineering fields. Economic, high-performance, and customized 3D printed structural materials will be generated to benefit national corporations and enterprises and meet the high-end industry needs.Read moreRead less
A novel multiscale model to investigate mechanical properties of cartilage. This project aims to develop a new multiscale model to investigate anisotropic and inhomogeneous mechanical properties of cartilage. It has been found that the mechanical properties of cartilage highly depend on its microstructures and components. The new model is proposed based on a new constitutive relation in the macroscale and a novel algorithm to obtain local stress distributions in the microscale as well as through ....A novel multiscale model to investigate mechanical properties of cartilage. This project aims to develop a new multiscale model to investigate anisotropic and inhomogeneous mechanical properties of cartilage. It has been found that the mechanical properties of cartilage highly depend on its microstructures and components. The new model is proposed based on a new constitutive relation in the macroscale and a novel algorithm to obtain local stress distributions in the microscale as well as through rigorous experimental validations. This model will be a powerful tool to understand cartilage mechanical properties. It will accelerate the design of mechanically viable artificial cartilage biomaterial, which will provide significant economic benefits and place Australia in the forefront of modelling and biomaterials.Read moreRead less
A Multiscale Modelling Framework for Mechanical Properties of ECM. This project aims to develop a novel hierarchical multi-scale modelling framework to understand factors that influence the mechanical deformation behaviour of the extracellular matrix (ECM) such as cartilage, whose mechanical performance is critical to human wellbeing. Modelling ECM presents significant challenges due to the need to incorporate effects at scales from atomic interactions up to the fibre network in a continuum mode ....A Multiscale Modelling Framework for Mechanical Properties of ECM. This project aims to develop a novel hierarchical multi-scale modelling framework to understand factors that influence the mechanical deformation behaviour of the extracellular matrix (ECM) such as cartilage, whose mechanical performance is critical to human wellbeing. Modelling ECM presents significant challenges due to the need to incorporate effects at scales from atomic interactions up to the fibre network in a continuum model. The proposed framework follows ECM's natural hierarchical structure and integrates efficient models for each key structural scale based on rigorous experimental validations. It is expected to provide a powerful tool for designing successful artificial ECM materials and understanding the mechanisms of the ECM degradation.Read moreRead less
Minimization of emissions from dimethyl ether (DME) combustion in a diesel engine. The project works on the utilization of dimethyl ether, an innovative clean fuel produced from coal or natural gas, as a diesel substitute. The utilization of DME in diesel engines can potentially reduce the emissions by 90%, making it possible to meet the strictest engine standard. In the meantime the engine efficiency can be improved. The outcomes of the project will help accelarate the maturity of the DME mark ....Minimization of emissions from dimethyl ether (DME) combustion in a diesel engine. The project works on the utilization of dimethyl ether, an innovative clean fuel produced from coal or natural gas, as a diesel substitute. The utilization of DME in diesel engines can potentially reduce the emissions by 90%, making it possible to meet the strictest engine standard. In the meantime the engine efficiency can be improved. The outcomes of the project will help accelarate the maturity of the DME market in Australia. Read moreRead less
Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nan ....Dislocation motion and anelastic recovery in layered ceramic titanate. This project aims to research deformation and facture in brittle ceramic nanowire materials and anelastic behaviour in tensile deformation. Layered sodium titanate is used in energy storage and water treatment, but in-situ tensile tests have observed unconventional deformation behaviour, with significant dislocation motion and anelastic recovery. This project will study the deformation mechanism in layered sodium titanate nanowires through molecular dynamics simulations, empirical interatomic potential, and in situ TEM experiments. Expected outcomes include knowledge of the deformation mechanism of this layered titanate which can be broadened to technologically important layered ceramic materials.Read moreRead less
Innovative multiscale modelling to explore mechanical properties of single living cells. This project will develop a new modelling platform to explore the relationship between living cell mechanical properties, their response to mechanical loads and their biological functions. Providing knowledge beyond current experimental measurements, this model will support studies into new treatments and preventions for diseases.
A novel multiscale modelling technique to explore mechanical deformation of nanowires in high-performance devices. A novel multiscale modelling technique with a number of key innovations will be developed. This new model is capable of taking account of the surface effects which are important for nanowires and will enhance prediction accuracy and provide knowledge beyond current experimental measurements to underpin performance of new devices.
Development of Canonical Mist Filter Models. Over one million tonnes of oil (mist) is wasted every year – and emitted to the atmosphere through inefficient filtration. Over 50 per cent of energy usage in most process industries is for filtration and separation processes, yet mist filters and separators are largely designed by trial and error, resulting in sub-optimal, inefficient designs. Recent advances by the research team have, only now, made it possible to develop accurate models for such sy ....Development of Canonical Mist Filter Models. Over one million tonnes of oil (mist) is wasted every year – and emitted to the atmosphere through inefficient filtration. Over 50 per cent of energy usage in most process industries is for filtration and separation processes, yet mist filters and separators are largely designed by trial and error, resulting in sub-optimal, inefficient designs. Recent advances by the research team have, only now, made it possible to develop accurate models for such systems. This work intends to be the first to develop accurate, broadly applicable models for all processes in mist filters, thereby providing immense process efficiency benefits, together with improved worker and environmental protection, and less wastage of dwindling oil resources.Read moreRead less
Improved design and operational efficiency of small wind turbines in unsteady flows. The purpose of this research is to improve the design and performance of small wind turbines for energy generation. The expected outcomes are novel control strategies and mechanical designs that account for unsteady aerodynamics and its effects on structural loads and power quality. Recommendations to improve current design standards will be made.