The Effect Of Loading On The Size, Shape And Strength Of Cortical Bone During Different Stages Of Maturation
Funder
National Health and Medical Research Council
Funding Amount
$180,000.00
Summary
Osteoporosis is a condition in which the skeleton becomes fragile and susceptible to fractures. It is a public health problem that affects both men and women over the age of sixty. Although osteoporosis affects the elderly, the most opportune time to prevent osteoporosis may be during childhood. Physical activity is a lifestyle factor known to affect the strength of the skeleton. Bone density is commonly used as a measure of bone strength because it is easily measured and is related to the break ....Osteoporosis is a condition in which the skeleton becomes fragile and susceptible to fractures. It is a public health problem that affects both men and women over the age of sixty. Although osteoporosis affects the elderly, the most opportune time to prevent osteoporosis may be during childhood. Physical activity is a lifestyle factor known to affect the strength of the skeleton. Bone density is commonly used as a measure of bone strength because it is easily measured and is related to the breaking strength of bones. However changes in the shape of bones can also affect bone strength with or without an increase in bone density. Changes in bone shape in response to exercise in children or adults have rarely been investigated, and little is known about the effects of exercise on bone shape during different stages of growth. This study is the first to investigate how exercise during childhood may affect bone strength by changing bone shape. 45 elite female tennis players aged between 6 to 18 years have completed two years of this study. 90 novice and competitive male tennis players aged between 6 to 20 years and 60 healthy age matched controls will be asked to participate in this study. Measurements will be made annually for three years. The bone shape and density of the dominant and non-dominant arms of the players will be compared with the children who don't play tennis - comparisons will also be made between i) different stages of puberty and ii) girls and boys. The findings of this study are important because the lifestyle of children today may predispose them to a greater risk of osteoporosis late in life. Physical activity may be the most important modifiable protective factor against fragile bones in old age. The findings of this study will be the first to provide insight into whether there is a unique time during growth when exercise will result in the greatest increase in bone strength by changing bone shape.Read moreRead less
Structural Investigation Of The Major Histocompatibility Complex Class I Peptide-loading Complex
Funder
National Health and Medical Research Council
Funding Amount
$292,639.00
Summary
The identification and destruction of diseased cells by our immune system is essential to controlling the spread of infection. This proposal is aimed at the characterisation of the peptide-loading complex (PLC), a large molecular machine that facilitates a crucial step in the process of ‘flagging’ infected cells. Determining the 3D structures of its key components, as well the way in which they interact will help us understand how the PLC contributes to maintaining our body’s health.
THE BIOLOGY OF HUMAN DEC-205: A POTENTIAL ANTIGEN LOADING RECEPTOR FOR DENDRITIC CELLS
Funder
National Health and Medical Research Council
Funding Amount
$227,017.00
Summary
Dendritic Cells (DC) represent a unique subset of white blood cells which play a critical role in initiating the immune response. Foreign material from bacteria-viruses and potentially cancer cells are recognised by DC, taken inside, processed and presented with other signals to T and B Lymphocytes for a response. Several DC surface molecules may beinvolved in the recognition of foreign material. We have cloned human DEC-205, a molecule which is predicted to bind the sugar groups associated with ....Dendritic Cells (DC) represent a unique subset of white blood cells which play a critical role in initiating the immune response. Foreign material from bacteria-viruses and potentially cancer cells are recognised by DC, taken inside, processed and presented with other signals to T and B Lymphocytes for a response. Several DC surface molecules may beinvolved in the recognition of foreign material. We have cloned human DEC-205, a molecule which is predicted to bind the sugar groups associated with bacteria-viruses and to act as a foreign material recognition and loading receptor. This project seeks to synthesise components of DEC-205 to test the binding capacities of its different components to different sugars and other molecules. We will also establish its expression pattern and how this is regulated on different white blood cell types. It is also possible that DEC-205 transmits signals which activate the DC, and we will test for that possibility. Finally, we will attempt to exploit this knowledge for loading cancer target molecules into DC via DEC-205 to initiate a cancer vaccine response.Read moreRead less
Patellofemoral Arthritis: Efficacy Of Physiotherapy And Understanding The Role Of Joint Stress
Funder
National Health and Medical Research Council
Funding Amount
$616,430.00
Summary
Arthritis of the kneecap leads to considerable pain and difficulty with daily activities. This project is testing whether a physiotherapy treatment (8 sessions over 12 weeks) designed specifically for people with kneecap arthritis is effective. In order to understand more about kneecap arthritis, this project will calculate the force on the kneecap and its relationship to pain and other factors, including thigh and hip muscle strength, knee alignments and knee movements.
Computerised diffraction tomography for structural health monitoring. Structural health monitoring (SHM) offers the prospect of a quantum gain in performance and efficiency for the design and structural integrity management of high-value assets (e.g. aircraft). The aims of this project are to develop and validate efficient computational tools for:
(i) Characterising the scattering of the Lamb waves by defects or boundaries, and
(ii) Implementing robust and versatile approaches to tomographic i ....Computerised diffraction tomography for structural health monitoring. Structural health monitoring (SHM) offers the prospect of a quantum gain in performance and efficiency for the design and structural integrity management of high-value assets (e.g. aircraft). The aims of this project are to develop and validate efficient computational tools for:
(i) Characterising the scattering of the Lamb waves by defects or boundaries, and
(ii) Implementing robust and versatile approaches to tomographic imaging of laminar defects or damage from experimental/synthetic scattered field data.
This project will result in the development of a validated and versatile SHM system for quantifying damage that is analogous to computerised tomography in medical imaging.Read moreRead less
Active vibration control of a fluid loaded cylinder using inertial and reactive actuators. The active control technology outlined in this proposal presents a practical solution for low frequency noise problems associated with a submarine. The successful outcomes will be directly applicable to the Collins Class submarine, and thereby will greatly benefit Australia's naval defence industry. The active control transducer technology developed in this project will be patented, and has the potential t ....Active vibration control of a fluid loaded cylinder using inertial and reactive actuators. The active control technology outlined in this proposal presents a practical solution for low frequency noise problems associated with a submarine. The successful outcomes will be directly applicable to the Collins Class submarine, and thereby will greatly benefit Australia's naval defence industry. The active control transducer technology developed in this project will be patented, and has the potential to result in great commercial value for Australia. This project will contribute significantly to Australian research capacity in cutting-edge technologies in active vibration control. The collaboration between UNSW and the Maritime Platforms Division of DSTO will promote technology transfer and enhance Defence research expertise.Read moreRead less
Small Scale Turbulence. The thrust of the project is to gain a fundamental understanding of turbulence, which is the usual state of fluid motion. The focus will be principally on the smallest length scales of turbulence because of the potential that exists for developing a theoretical framework which can predict the behaviour of these scales accurately. Important insight will be gained into the manner in which temperature is mixed and convected by a turbulent flow.