Discovery Early Career Researcher Award - Grant ID: DE120101402
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Analysing cell-cell communication mechanisms using microfluidic platforms. The project employs advanced micro-engineered systems to explore the communication of cells. Cells are patterned in close contact and stimulated with physical and chemical stimulus while their response is monitored in real-time. The findings elucidate how malfunctioned cells affect neighbouring cells and how diseases are propagated in tissues.
Nano optoelectronic coupling: towards an ultrasensitive sensing technology. This project aims to elucidate ultrasensitive mechanical and thermal sensing effects that are tens of thousands of times better than conventional sensing technologies. This is achieved through controlling interactions between photons and electrons at the interface of two semiconductors. Outcomes of this project include scientific breakthroughs that are expected to revolutionise and disrupt the established sensing technol ....Nano optoelectronic coupling: towards an ultrasensitive sensing technology. This project aims to elucidate ultrasensitive mechanical and thermal sensing effects that are tens of thousands of times better than conventional sensing technologies. This is achieved through controlling interactions between photons and electrons at the interface of two semiconductors. Outcomes of this project include scientific breakthroughs that are expected to revolutionise and disrupt the established sensing technologies. Microscopic low power mechanical and thermal sensors with ultra-high sensitivity have great value to enhance safety, security, and productivity of industry and society. The project is expected to generate new knowledge and place Australia as the world leader in physical sensing and create a new industry.Read moreRead less
Microfluidic platforms for studying foam cell formation in vessels . This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective ma ....Microfluidic platforms for studying foam cell formation in vessels . This project aims to create technology platforms, utilising microfluidics and machine learning, to study the fundamental biological processes underlying the accumulation of immune cells underneath the vessel wall, which is known as foam cell formation. This project expects to deliver technologies, which facilitate mimicking and analysis of the complex dynamics of the human vessels in a more accurate, time- and cost-effective manner. The expected outcome will be cutting-edge tools and techniques to better understand the fundamental biological mechanisms driving foam cell formation. This should facilitate the development of future cardiovascular drug discovery technologies, which would benefit the biotechnology and pharmaceutical industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101073
Funder
Australian Research Council
Funding Amount
$355,000.00
Summary
Defying conventions with a liquid metal-embedded hybrid elastomer composite. Conductive elastic composites are one of the key components used in flexible/wearable electronic devices in the manufacture of sensors and interconnects; however, conventional composites experience a relatively low sensitivity to strain, and their conductivity decreases when stretched (i.e. they exhibit a negative piezoconductive effect). This project aims to understand the unprecedented positive piezoconductive effect ....Defying conventions with a liquid metal-embedded hybrid elastomer composite. Conductive elastic composites are one of the key components used in flexible/wearable electronic devices in the manufacture of sensors and interconnects; however, conventional composites experience a relatively low sensitivity to strain, and their conductivity decreases when stretched (i.e. they exhibit a negative piezoconductive effect). This project aims to understand the unprecedented positive piezoconductive effect exhibited on the liquid metal-embedded hybrid elastomer (LMHE) and explore its potential to address the key challenges faced by conventional materials. The outcomes of this project will benefit the advanced manufacturing sector by developing high-performance composites to revolutionise future wearable electronic technologies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100600
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
A microfluidic platform for optimised detection of protein complexes. This project aims to develop an integrated lab-on-a-chip platform interfacing droplet-based microfluidics with conventional mass spectrometry. The platform detects suitable protein complexes using a fraction of the samples used in conventional tools. The system creates droplets on demand, injects and mixes a controlled volume of reagents into a single droplet using an array of embedded electrodes. This technology will screen d ....A microfluidic platform for optimised detection of protein complexes. This project aims to develop an integrated lab-on-a-chip platform interfacing droplet-based microfluidics with conventional mass spectrometry. The platform detects suitable protein complexes using a fraction of the samples used in conventional tools. The system creates droplets on demand, injects and mixes a controlled volume of reagents into a single droplet using an array of embedded electrodes. This technology will screen drug-like samples. This technology is expected to replace traditional time-consuming drug screening techniques, and reduce time and cost of drug discovery. Its commercialisation would complement the existing tools in the pharmaceutical industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100692
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Multiphysics inertial microfluidics: from fundamentals to applications. Separation of particles and particularly cells is an indispensable process in disease diagnostics, chemical/biological assays and food/chemical industries. This project aims to study the interplay between inertial fluid flow, electricity, and magnetism in microscale for particle separation. The project is expected to establish the fundamental theory underpinning the development of the proposed advanced separation technology. ....Multiphysics inertial microfluidics: from fundamentals to applications. Separation of particles and particularly cells is an indispensable process in disease diagnostics, chemical/biological assays and food/chemical industries. This project aims to study the interplay between inertial fluid flow, electricity, and magnetism in microscale for particle separation. The project is expected to establish the fundamental theory underpinning the development of the proposed advanced separation technology. This disruptive technology is expected to enable the unique, high-performance and high-throughput separation of particles such as cells. The technology will potentially benefit the biomedical and pharmaceutical industries, providing economic opportunities and maintaining high-quality healthcare for Australia.Read moreRead less
Subsurface Atomic Force Microscopy using Dual Probes. The proposal aims to develop a new microscopy method for imaging nano-scale structures buried below the surface of a sample; for example, metal conductors in a computer processor chip. The expected outcome is a new method for creating subsurface images with an application focus on semiconductor device inspection and quality control. The proposed microscope is expected to create new economic opportunities including new commercial products, int ....Subsurface Atomic Force Microscopy using Dual Probes. The proposal aims to develop a new microscopy method for imaging nano-scale structures buried below the surface of a sample; for example, metal conductors in a computer processor chip. The expected outcome is a new method for creating subsurface images with an application focus on semiconductor device inspection and quality control. The proposed microscope is expected to create new economic opportunities including new commercial products, intellectual property, and the potential for a start-up venture. The benefits to Australia should include the creation of new job opportunities and the development of local expertise in a high-value market sector.Read moreRead less
Magnetofluidic sample handling for enhanced point-of-care diagnosis. This project aims to decipher the mechanism behind recent discovery on the enhancement of mixing and separation with magnetism and to apply it to the rapid and early detection of malaria and cancer. This mechanism provides novel and unique fluid handling capabilities, which allow the development of revolutionary point-of-care diagnostic approaches that integrate magnetic mixing, separation and detection on a single device. The ....Magnetofluidic sample handling for enhanced point-of-care diagnosis. This project aims to decipher the mechanism behind recent discovery on the enhancement of mixing and separation with magnetism and to apply it to the rapid and early detection of malaria and cancer. This mechanism provides novel and unique fluid handling capabilities, which allow the development of revolutionary point-of-care diagnostic approaches that integrate magnetic mixing, separation and detection on a single device. The outcomes of this project are instrumental for the reduction of healthcare cost, promoting good health for Australian and potentially creating new jobs in the niche biomedical industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100852
Funder
Australian Research Council
Funding Amount
$440,675.00
Summary
High-Performance Monolithic Sensor Technology for Corrosive Environments. Based on my recent discovery on giant thermo-/piezo-resistance, this project aims to enhance fundamental understanding and enable the development of high performance silicon carbide based sensors. The project employs these knowledge advancements to develop new sensors with a sensitivity of thousand-fold larger than that of conventional sensors. The project develops multiple sensors and light harvesting cells to be integr ....High-Performance Monolithic Sensor Technology for Corrosive Environments. Based on my recent discovery on giant thermo-/piezo-resistance, this project aims to enhance fundamental understanding and enable the development of high performance silicon carbide based sensors. The project employs these knowledge advancements to develop new sensors with a sensitivity of thousand-fold larger than that of conventional sensors. The project develops multiple sensors and light harvesting cells to be integrated into a monolithic platform that can function in corrosive environments. The sensor technology can be utilised for monitoring structural health, reducing failure and extending lifetime of structures, providing cutting-edge knowledge to petrochemical and mining industries which are of particular importance to Australia.Read moreRead less