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The Role Of The Human RECK Protein In Modifying Human Sarcoma Progression Within In Vitro And In Vivo Models
Funder
National Health and Medical Research Council
Funding Amount
$34,878.00
Summary
The protein “RECK” is known to have a controlling effect on cancers by reducing growth, invasion, and blood supply. RECK is present in normal tissues but in bone and soft-tissue tumours (sarcomas), the protein is reduced. This study aims to; correlate RECK levels in sarcoma with patient survival, use gene technology to increase RECK levels in sarcoma cells, and observe the effects on sarcoma invasion and metastasis.
EFFECT OF LIPOXIN A4 AND PROSTAGLANDIN E2 IN ASSISSTED BONE HEALING
Funder
National Health and Medical Research Council
Funding Amount
$118,796.00
Summary
Bone healing and repair following trauma involves a complex series of events at both the cellular and molecular levels. This study aims to determine that local application of optimal dose of lipoxin A4 (promote resolution of inflammation) and prostaglandin E2 (low dosage stimulating localised bone formation) will promote healing following the placement of polymer foam in the defect, there by develop a therapy where bone deposition is accelerated and healing is enhanced.