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Endocrine And Molecular Regulation Of Placental CRH Expression
Funder
National Health and Medical Research Council
Funding Amount
$466,980.00
Summary
Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotr ....Approximately 70% of infant death is associated with premature birth. Preterm birth occurs in 6-10% of pregnancies, and there has been no reduction in the rates of premature birth in the last 30 years. This is largely because we remain ignorant of how normal and abnormal birth is controlled. Understanding the physiology of human pregnancy is a critical step in the development of ways to detect and prevent preterm birth. Our group has demonstrated a link between production of a hormone (corticotrophin releasing hormone, CRH) in the placenta and the length of time the baby is carried in the mother. In women who will deliver prematurely a rise in CRH occurs earlier in the pregnancy and more rapidly, while in women who deliver late the rise occurs more slowly. This work has given rise to the concept of a biological clock that determines the length of time the fetus will be carried by the mother before birth, and in which production of CRH in the placenta plays a central role. We have been studying how the CRH gene is controlled in placental cells. We have discovered some regions in the DNA of the CRH gene which have important roles in controlling how much CRH is made by the placenta. The experiments described in this research project will determine the molecular mechanisms that control the production of CRH in the human placenta. This will be done in two ways: (1) by examining the DNA sequences involved in controlling expression of the CRH gene and (2) by identifying the proteins that actually perform the regulating functions that result in either increased or decreased amounts of CRH being produced by the placenta. This important information will help us better understand how normal and abnormal birth is controlled, and from that knowledge new ways to detect and prevent premature birth can be invented.Read moreRead less
Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of ma ....Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of marketing strategies used to sell sports wagering in Australia; important qualitative insights into the impact of these marketing strategies on gambling behaviours; and, recommendations for a comprehensive public health approach to help counter the potential long and short term risks associated with sports wagering marketing.Read moreRead less
The big gamble: an interdisciplinary study of the normalisation of gambling. This project aims to explore industry and socio-cultural factors that contribute to the normalisation of gambling. Gambling is recognised as an urgent public health issue in Australia, posing a health threat to individuals and communities. However, there is limited empirical evidence about the processes that may contribute to the normalisation of different forms of gambling. This project aims to explore the interplay be ....The big gamble: an interdisciplinary study of the normalisation of gambling. This project aims to explore industry and socio-cultural factors that contribute to the normalisation of gambling. Gambling is recognised as an urgent public health issue in Australia, posing a health threat to individuals and communities. However, there is limited empirical evidence about the processes that may contribute to the normalisation of different forms of gambling. This project aims to explore the interplay between the sophisticated promotional tactics used by the gambling industry, and the socio-cultural mechanisms which may interact with these promotional tactics to normalise gambling beliefs in youth, women, and older adults. This project expects to help local governments and related stakeholders develop a comprehensive range of public health strategies aimed at preventing the risks and harms posed by the normalisation of gambling.Read moreRead less
Special Research Initiatives - Grant ID: SR0354823
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and appl ....National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and applying theoretically-driven models of psychotic symptoms.
2) Disseminate the findings of research on CBT for psychotic disorders in clinical settings by (a) training the work-force, and (b) facilitating CBT delivery in routine practice.
3) Apply CBT in various settings with a variety of psychotic populations to test its effectiveness in routine clinical settings.
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Moving from policy to practice: a randomised trial of an implementation intervention to facilitate the adoption of a statewide healthy canteen policy. This project will test the effectiveness of an intervention in supporting schools to implement a healthy canteen policy mandated by the New South Wales Government. The trial could provide a model for supporting schools to implement school health or education policies which seek to improve the wellbeing of students.
Determinants of children's physical activity and sedentary behaviour: a follow-up study from early childhood. This project investigates changes in preschool children's physical activity and sedentary behaviour, and influences on these changes, during the important period of transition to school. It will provide important information on how we might assist children to be more active, thereby avoiding the detrimental health and social outcomes of inactivity.
A randomised trial of an intervention to maintain alcohol management practices in community sporting clubs. Despite significant investment in implementation, many public health initiatives fail to persist when program funding and resources are reduced, limiting the benefits to the community. This project will investigate the effectiveness of a web-based intervention in sustaining the impact of an alcohol management intervention in community sports clubs.
Community capacity building for healthy lifestyles (CBHL) initiative: engaging communities in childhood obesity prevention in disadvantaged areas. This project will develop and focus-test a new community engagement model for engaging disadvantaged communities in childhood obesity prevention programs. The community engagement model will overcome disadvantaged communities' non-participation in prevention programs, and inform culturally tailored childhood obesity prevention strategies.
Understanding fertility management in contemporary Australia. Fertility management, including unintended pregnancy and infertility carry substantial public costs including increased health service use and reduced economic participation. Both are experienced in individual lives, contributing to disappointed life goals, altered social and family relationships, the burden of stigma, and compromised physical and mental health. The goal of this research is to reduce the public and personal costs of s ....Understanding fertility management in contemporary Australia. Fertility management, including unintended pregnancy and infertility carry substantial public costs including increased health service use and reduced economic participation. Both are experienced in individual lives, contributing to disappointed life goals, altered social and family relationships, the burden of stigma, and compromised physical and mental health. The goal of this research is to reduce the public and personal costs of sub-optimal fertility management by providing the knowledge for improving national reproductive and sexual health promotion strategies. The consequence will be increased likelihood that pregnancies are intended and reproductive hopes realised. Data will contribute to National Research Priorities of promoting health and strengthening families.Read moreRead less
A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic ev ....A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic evaluation, improving the quality of life and wellbeing of older Australians, and will assist in determining the relative cost effectiveness of new and existing services.
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