Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
Postviral Wheezing In Childhood: Disregulation Of Airway Tone?
Funder
National Health and Medical Research Council
Funding Amount
$577,040.00
Summary
Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. Ho ....Asthma is a very common childhood condition that is becoming increasingly more common. Wheezing is common in infants and young children following viral infections and is often thought of as the first manifestation of asthma. However, many children and infants who wheeze with viral infections appear to grow out of asthma in their teenage years. Asthma that persists into adult life is usually associated with allergies to common environmental allergens, such as house dust mite and grass pollens. However, many infants who wheeze with viral infections, especially in the first year of life, do not develop allergies in later life, raising the possibility that they did not have the same type of asthma as those whose symptoms persist. This project will study the effects of viral infections on lung function to determine whether particular types of virus can have detrimental effects of lung function lasting for years. We will also examine whether the age at which the infection occurs and the severity of the infection influence the long-term outcome. The project involves studying infants during the recovery phase of respiratory viral infections, older children years after documented infections and experimental animal models that have been infected under controlled conditions. By determining whether respiratory viral infections can have long-term effects on lung function that can mimic asthma, we will advance our understanding of how asthma develops. In addition, specific treatment and preventative strategies could then be developed to prevent these long-term abnormalities, instead of relying on asthma medication (especially inhaled corticosteroids) as is the current practice. Preventative strategies could include encouraging the development of specific vaccines.Read moreRead less
The Long-term Consequences Of Assisted Reproduction On The Growth, Metabolic, Respiratory, Psychological, Immunological And Reproductive Development Of The Offspring.
Funder
National Health and Medical Research Council
Funding Amount
$1,552,096.00
Summary
1 in 25 children are born from IVF treatment - incredibly- to our shame; no data exists as to the long-term health of these children. Presented is a unique opportunity, which would be exceedingly difficult to replicate elsewhere in the world, to determine the long-term consequences of IVF upon the development of the offspring, by comparing their growth, metabolic, respiratory, psychological, immunological and reproductive development to a representative sample of WA children- the Raine cohort.
Damage micromechanisms in alumina hybrid bilayers with graded interfaces. This project proposes a new design concept for high performance alumina hybrids with graded interfaces. The key to this process is the incorporation of thin graded interfaces between an outer homogeneous alumina layer for strength, hardness and wear resistance, and an inner heterogeneous alumina hybrid layer for damage tolerance. The project will explore unresolved issues concerning the effect of graded interfaces on the f ....Damage micromechanisms in alumina hybrid bilayers with graded interfaces. This project proposes a new design concept for high performance alumina hybrids with graded interfaces. The key to this process is the incorporation of thin graded interfaces between an outer homogeneous alumina layer for strength, hardness and wear resistance, and an inner heterogeneous alumina hybrid layer for damage tolerance. The project will explore unresolved issues concerning the effect of graded interfaces on the failure micromechanisms. Advances in this area will provide new strategy or insights for designing novel next generation layered materials.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101795
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Exceptional properties by design – NiTi vision. The fundamental leaps in new technologies occur with improvements in the materials with which they are made. Until recently high performance metallic composite design had hit a 20 year blockage in nanocomposite design. The solution, a Nickel, Titanium and Niobium (NiTi-Nb) nanowire composite has been heralded as an era of new possibilities in materials design. This project aims to advance high performance metallic composite design by investigating ....Exceptional properties by design – NiTi vision. The fundamental leaps in new technologies occur with improvements in the materials with which they are made. Until recently high performance metallic composite design had hit a 20 year blockage in nanocomposite design. The solution, a Nickel, Titanium and Niobium (NiTi-Nb) nanowire composite has been heralded as an era of new possibilities in materials design. This project aims to advance high performance metallic composite design by investigating the mechanisms of exceptionally large elastic strains achieved in nanowires embedded in a phase-transforming metallic matrix (i.e. NiTi). An understanding of this high performance nanocomposite design has broad application in medicine and engineering.Read moreRead less
Effects of Phase Purity, Porosity and Oxygen Partial Pressure on the Thermal Stability of Nanolayered Ternary Carbides. The successful completion of this collaborative research will lead to (a) enhanced understanding of the roles of phase purity, porosity and atmosphere on the thermal stability of ternary carbides which is crucial for the design of high-performance ternary carbide heating elements; (b) fostering and strengthening of the continuing research collaboration between Curtin University ....Effects of Phase Purity, Porosity and Oxygen Partial Pressure on the Thermal Stability of Nanolayered Ternary Carbides. The successful completion of this collaborative research will lead to (a) enhanced understanding of the roles of phase purity, porosity and atmosphere on the thermal stability of ternary carbides which is crucial for the design of high-performance ternary carbide heating elements; (b) fostering and strengthening of the continuing research collaboration between Curtin University and the Institute of Metals Research; (c) development of high performance prototype ternary carbide heating elements for use in high temperature furnaces and ovens; and (d) potential joint ventures with local suppliers of furnaces in Australia and China, together with Kanthal of Sweden to assist in the manufacture of ternary carbide heating elements. Read moreRead less
Synthesis of Novel Nanostructured Ternary Carbide Composites. This research will lead to (a) new advances and provide contribution of new knowledge to the Priority Research Areas of Advanced Materials; (b) a novel vacuum heat-treatment process for nanostructured materials design. This will offer the ceramics industry in Australia a new technology for producing wear- and heat-resistant components for advanced engineering applications. (c) design of new layer-graded materials with a unique combina ....Synthesis of Novel Nanostructured Ternary Carbide Composites. This research will lead to (a) new advances and provide contribution of new knowledge to the Priority Research Areas of Advanced Materials; (b) a novel vacuum heat-treatment process for nanostructured materials design. This will offer the ceramics industry in Australia a new technology for producing wear- and heat-resistant components for advanced engineering applications. (c) design of new layer-graded materials with a unique combination of hardness for wear resistance and toughness for damage tolerance. This will enable the ceramics industry in Australia to compete internationally in the business of advanced and high performance ceramic products.Read moreRead less
Development of three-dimensional printing conductive concrete for electromagnetic pulse shielding. This project aims to develop innovative methods for the use of conductive concrete as a building material with an electromagnetic pulse (EMP) shielding property. Three dimensional printing of conductive concrete will present an innovative and promising technique in real-life construction practices when structures are needed for facilities and infrastructure employed for critical services such as mi ....Development of three-dimensional printing conductive concrete for electromagnetic pulse shielding. This project aims to develop innovative methods for the use of conductive concrete as a building material with an electromagnetic pulse (EMP) shielding property. Three dimensional printing of conductive concrete will present an innovative and promising technique in real-life construction practices when structures are needed for facilities and infrastructure employed for critical services such as military or financial infrastructures. The project will create new revenue streams for cement and concrete industry as well as empower the workforce with cutting-edge skills. The newly developed materials and technology will lead to protection of national facilities and infrastructure.Read moreRead less
Development of nano reinforced concrete using boron nitride nanosheets. This project seeks to develop high-performance concrete materials by exploiting emerging nanotechnology. It plans to adopt emerging nanotechnology involving hexagonal boron nitride nanosheets and advanced micro-computer tomography instrumentation to transform conventional concrete into one that is stronger and more durable in extreme environmental conditions. It also plans to use sophisticated modelling techniques including ....Development of nano reinforced concrete using boron nitride nanosheets. This project seeks to develop high-performance concrete materials by exploiting emerging nanotechnology. It plans to adopt emerging nanotechnology involving hexagonal boron nitride nanosheets and advanced micro-computer tomography instrumentation to transform conventional concrete into one that is stronger and more durable in extreme environmental conditions. It also plans to use sophisticated modelling techniques including molecular dynamics simulations as well as microplane models to analyse the effect of nanofillers. The findings may drive advances in cement hydration, nanotechnology, concrete technology and blast, impact and fire engineering.Read moreRead less