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Development Of Small Molecule Isoform-Selective Dynamin Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$85,526.00
Summary
Dynamin has roles in nerve cell communication and in cell division. There are 3 dynamin genes: dynamin I in brain; dynamin II in all cells; and dynamin III in brain and testes. Determination of potential selectivity of small molecule dynamin inhibitors for each dynamin gene can provide a basis for the development of new antiepileptic drugs which are specific for dynamin I and thus neuronal tissues, as well as new anticancer drugs that target dynamin II in nonneuronal cells.
Brain diseases such as epilepsy and Alzheimer�s are linked to the activation of synapses, contact points between nerve cells. Synapses absorb and release neurotransmitters in the cyclic process of endocytosis & exocytosis allowing nerve cell communication. This study aims to identify the master controllers, protein kinases, which are essential to reset the process after each cycle. These proteins can be exploited as targets in drug discovery programs to treat common neurological diseases.