Development Of Site-specific Predictive Assay For Periodontal Disease Progression Using Mass Spectrometric &RT- PCR Anal
Funder
National Health and Medical Research Council
Funding Amount
$150,000.00
Summary
In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crev ....In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crevicular fluid. This could provide insight into the development of periodontal disease and lead to new preventive and treatment regimes.Read moreRead less
SEARCH - Study Of Environment On Aboriginal Resilience And Child Health
Funder
National Health and Medical Research Council
Funding Amount
$2,114,618.00
Summary
The SEARCH program of research investigates the relationship between environmental determinants of health in a cohort study with five year follow up involving 800 urban NSW Aboriginal families with approximately 2000 children aged 0-17. A subset of 480 families will be recruited to participate in a randomised controlled trial of the impact of a health broker on (i) improving treatment of otitis media, and (ii) a feasibility study of an intervention to improve housing in 50 households. These two ....The SEARCH program of research investigates the relationship between environmental determinants of health in a cohort study with five year follow up involving 800 urban NSW Aboriginal families with approximately 2000 children aged 0-17. A subset of 480 families will be recruited to participate in a randomised controlled trial of the impact of a health broker on (i) improving treatment of otitis media, and (ii) a feasibility study of an intervention to improve housing in 50 households. These two studies will form the basis of an urban Aboriginal cohort study spanning 20 years with funding from alternate sources.Read moreRead less