Family Study Of Ear Health And Metabolic Diseases In A Western Australian Aboriginal Community
Funder
National Health and Medical Research Council
Funding Amount
$1,054,741.00
Summary
A family-based study of diseases in a Western Australian Aboriginal community is planned. Patterns in DNA within families will be related to patterns of disease in two areas of health that are of major concern to this Aboriginal community, ear health in children (e.g. runny ears; perforated eardrums) and type 2 diabetes. Finding genetic determinants of disease provides information that can complement clinical, epidemiological and public health understanding of disease.
Identification Of Biomarkers For Alzheimers Disease
Funder
National Health and Medical Research Council
Funding Amount
$607,489.00
Summary
Alzheimer's disease is the most common age-related neurodegenerative disease, and the most common cause of dementia. It is estimated that 212,000 Australians suffer from dementia and this will rise to approximately 730,000 by 2050. Currently there are no definitive diagnostic methods for AD. The research described in this application seeks to identify and validate a range of biomarkers identified in the blood of patients that would be suitable to use for diagnostic purposes.
Metabolomic Analysis Of Leishmania Parasites; Identifying Metabolic Pathways Required For Pathogenesis
Funder
National Health and Medical Research Council
Funding Amount
$605,963.00
Summary
Leishmania are single-celled parasites that target a major class of immune cell, affecting millions and killing thousands of people worldwide. We have developed new approaches for investigating how these parasites survive in the immune cells, and why different species of Leishmania cause markedly different pathologies. This information will be used to identify and validate new drug targets in these parasites.
Development Of High-throughput Screening Assays For Detecting Early Gastric Cancer: Translating Proteomics Research Into Clinical Outcomes Using Emerging Mass Spectrometry And Photonics Technologies
Funder
National Health and Medical Research Council
Funding Amount
$655,438.00
Summary
Gastric cancer (GC) is the second leading cause of cancer death worldwide, claiming the lives of >11,000 Australians from 1996-2006. Individuals diagnosed with GC have an expected 5-year survival rate of 10-30%. This could be improved if cases were identified in the early stages of the disease where treatments are more effective. Researchers from Adelaide and Melbourne are developing a diagnostic assay for early-stage GC based on a novel detection system that requires only a drop of blood.
Biochemistry And Functional Significance Of Glycosylation Of Apolipoprotein E
Funder
National Health and Medical Research Council
Funding Amount
$485,000.00
Summary
Apolipoprotein E (apoE) is an important molecule which affects our risk of atherosclerosis- coronary disease and of Alzheimer's disease. We know that apoE's functions are very much affected by its structure. One aspect of tis structure which has been neglected is the attachment of sugar molecules . These are very likely to regulate how apoE interacts with other molecules, with cells, and is metabolised in the body and will be investigated in this project.
A Longitudinal Study Of Bone Development In Children
Funder
National Health and Medical Research Council
Funding Amount
$144,750.00
Summary
Osteoporosis is a major public health problem resulting in 50-75,000 fractures each year in Australia costing the community about 800 million dollars per annum. Bone strength is a risk factor for fractures in both childhood and in later life. Relatively little is known about bone development with the exception of calcium intake and physical activity. This study will follow 500 children from birth in 1988 to 2004 with the aim of understanding the contribution of lifestyle factors to bone developm ....Osteoporosis is a major public health problem resulting in 50-75,000 fractures each year in Australia costing the community about 800 million dollars per annum. Bone strength is a risk factor for fractures in both childhood and in later life. Relatively little is known about bone development with the exception of calcium intake and physical activity. This study will follow 500 children from birth in 1988 to 2004 with the aim of understanding the contribution of lifestyle factors to bone development in this time period.Read moreRead less