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Structural And Functional Networks In The Human Brain: Disturbance In Disease And Influence Of Genes.
Funder
National Health and Medical Research Council
Funding Amount
$568,892.00
Summary
Professor Graeme Jackson is a Neurologist at the Austin Hospital whose research is dedicated to the problem of understanding how epilepsy occurs and devising strategies for successful treatment. He is Deputy Director and head of the epilepsy division of the Florey Neuroscience Institutes which has research dedicated advanced MR imaging systems and physics support largely dedicated to solving these problems in epilepsy. He has 170 plus papers, 10 cited over 200 times. Career citations exceed 6000 ....Professor Graeme Jackson is a Neurologist at the Austin Hospital whose research is dedicated to the problem of understanding how epilepsy occurs and devising strategies for successful treatment. He is Deputy Director and head of the epilepsy division of the Florey Neuroscience Institutes which has research dedicated advanced MR imaging systems and physics support largely dedicated to solving these problems in epilepsy. He has 170 plus papers, 10 cited over 200 times. Career citations exceed 6000.Read moreRead less
Improving Human FMRI Through Modeling And Imaging Microvascular Dynamics
Funder
National Health and Medical Research Council
Funding Amount
$486,144.00
Summary
In this project we aim to establish a reliable vascular baseline to improve mapping of both small-scale functional architecture and large-scale brain networks in functional human brain mapping using MRI. By mapping the grey matter vasculature with high detail in both humans and animals, and by computing and matching of these atlases across species we will be able to validate this approach in vivo to confirm the better spatial specificity of the newly developed approach.
Evaluation Of Renal Masses Using Magnetic Resonance
Funder
National Health and Medical Research Council
Funding Amount
$657,897.00
Summary
This project will investigate use of an imaging instrument to identify renal cancers that are potentially harmless from aggressive renal cancers. Currently, such differentiation requires biopsies, and the outcome is often unnecessary surgical removal of whole or part of the diseased kidney. Long term, this project will provide knowledge to determine aggressiveness of a renal cancer non-invasively, without having to perform an operation. The approach was previously successful for breast cancer.
We have previously made the most widely used animal brain atlas in the world. This atlas based on stained histological sections of the rat brain. In recent years, advances in MRI have made it possible to generate images of the rat brain at very high resolution. We have obtained a very high quality MRI image set from colleagues in Duke University in the USA, and we have begun to map these images in great detail, using our histological atlas as a guide.
Magnetic Resonance Imaging Of Structural And Functional Connectivity In Lesion-negative Temporal Lobe Epilepsy Compared To Hippocampal Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$99,883.00
Summary
Epileptic seizures in the temporal lobe of the brain can affect how the temporal lobe connects to other brain regions. We are using new MRI techniques to investigate these altered connections, in patients who have no other abnormality on their brain scans. Our aim is to find distinctive patterns of altered connectivity, which will help us better understand this type of epilepsy.
Novel Approaches To Improve Cognitive Recovery Following Stroke And Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$344,724.00
Summary
Stroke and traumatic brain injury costs the Australian economy over $13 billion, annually. Both disorders result in impaired cognition that impedes individuals’ return to the community. Current rehabilitation strategies, however, fail to adequately rehabilitate cognitive deficits following these disorders. My fellowship will develop new strategies to improve rehabilitation of cognitive functions by using cutting-edge neuroimaging and electrophysiological techniques.
Radiological Features Correlating With Seizures In Patients With Supratentorial Gliomas
Funder
National Health and Medical Research Council
Funding Amount
$47,877.00
Summary
Gliomas are the most common brain tumours, with more than 1,500 new cases diagnosed in Australia each year. Around 50% of all glioma patients suffer from seizures, which are difficult to control with current anti-epileptic drugs. The epilepsy and the side-effects of the drug therapies are a major cause of morbidity and impaired quality of life. It is also a significant burden on the economy, leading to more and longer hospital admissions, and loss of productivity for both patients and carers.
Novel Nanomaterial Solutions Based On Metal And Metal Oxide For Advanced Diagnosis Of Cardiovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$581,037.00
Summary
Cardiovascular disease accounts of over one third of all deaths in Australia and is forecasted to become the leading cause of death in Australia and worldwide. Currently, atherosclerosis and thrombosis in coronary arteries are diagnosed by X-ray angiography, an invasive and risk-associated procedure. Our project will explore new contrast agents for the fast, reliable and safe diagnosis of cardiovascular diseases and thrombotic events, which is beneficial to many patients.
Imaging Of Acute Ischemic Stroke – Improving Patient Selection For Thrombolysis
Funder
National Health and Medical Research Council
Funding Amount
$367,946.00
Summary
Stroke is a major cause of death and disability in our community and is most often due to a blocked blood vessel. Powerful treatments are available to open blocked blood vessels but there are restrictions on eligibility and some risks. This research aims to improve doctors' understanding of stroke in the individual patient to aid treatment decisions by identifying those with potentially salvageable brain tissue and avoiding those with high risk of bleeding complications.
Harnessing Imaging And IT Strategies To Expedite Targeted Treatment And Improve Outcomes In Cerebrovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,914,215.00
Summary
This project will expand on my 25+ years of research in combining neuroimaging methods such as CT and MRI with nascent software tools to better target and coordinate treatment and achieve improved outcomes in cerebrovascular diseases such as stroke. We will develop & improve new CT and MRI methods and leverage latest advances in computer science, such as deep learning and mobile phone app technology, to achieve faster and more accurate identification of patients who can benefit from treatment.