TARGETING OF G-CSF IN COMBINATION WITH STANDARD THERAPY FOR ADVANCED BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$583,166.00
Summary
Nearly all deaths caused by breast cancer are due to the spread of the cancer to other tissues such as lung and bone, ultimately leading to organ failure and death. The process of spread of cancer cells is not well understood, but it is becoming clear that cells of the immune system are key regulators of the spread of breast cancer. It is the aim of this project to target two types of immune cells, macrophages and neutrophils, seeking therapies that prevent the growth of secondary cancers.
Investigation Of The Molecular Basis Of Human Nevogenesis And Melanoma Initiation
Funder
National Health and Medical Research Council
Funding Amount
$598,220.00
Summary
The number of moles and lifetime exposure to solar UV are the major risk factors in melanoma development. A genetic association between the IRF4 gene and mole number and melanoma susceptibility has been reported. We propose that changes in the function of this gene will impact on the behaviour of melanocytes/melanoma cells, their response to UV radiation and interaction with surrounding cells. Understanding the function of this gene will provide crucial insight into the initiation of melanoma.