Microspheres from (Sun)Light – A Sustainable Materials Platform. This project will break new ground in light-induced step-growth precipitation polymerisation techniques for polymer particle formation that do not require any initiator, surfactants, additives or heating, thus constituting an environmentally friendly process. The project will establish the underpinning photochemical particle formation processes and establish a broad monomer base for the production of particles with a wide property ....Microspheres from (Sun)Light – A Sustainable Materials Platform. This project will break new ground in light-induced step-growth precipitation polymerisation techniques for polymer particle formation that do not require any initiator, surfactants, additives or heating, thus constituting an environmentally friendly process. The project will establish the underpinning photochemical particle formation processes and establish a broad monomer base for the production of particles with a wide property profile, including particles with tailored surface properties and the ability to degrade upon a defined trigger signal. Scaling the particles' synthesis, including using Australian sunlight, will enable multi-gram production allowing real-world applications.Read moreRead less
An in-built depolymerisation solution for polyethylene waste. This project aims to design enzymes that can be embedded into polyethylene, and later activated by the elevated temperatures of a compost heap, to depolymerise the plastic to small molecules. There are no good options available for the controlled decomposition of polyethylene waste at present, and instead researchers have focussed on solutions that rely on modifications to the underlying chemistry of the backbone and or collection to ....An in-built depolymerisation solution for polyethylene waste. This project aims to design enzymes that can be embedded into polyethylene, and later activated by the elevated temperatures of a compost heap, to depolymerise the plastic to small molecules. There are no good options available for the controlled decomposition of polyethylene waste at present, and instead researchers have focussed on solutions that rely on modifications to the underlying chemistry of the backbone and or collection to a central facility. Our approach would result in an in-built decomposition that does not require collection and recycling in a central facility. Since it is based on a depolymerisation mechanism it does not result in the production of harmful, partially disintegrated microplastics.Read moreRead less
New Strategies for Modelling Polyoxometalates. Polyoxometalates are a versatile class of genuine nanomaterials with remarkable chemical and physical properties and dimensions ranging from tens to tens of thousands of atoms. Designing functional materials which exploit their enormous potential is limited by practical difficulties in their structural characterization and restrictions on our ability to model their behaviour. In this project, we will develop a new strategy for computer modelling of ....New Strategies for Modelling Polyoxometalates. Polyoxometalates are a versatile class of genuine nanomaterials with remarkable chemical and physical properties and dimensions ranging from tens to tens of thousands of atoms. Designing functional materials which exploit their enormous potential is limited by practical difficulties in their structural characterization and restrictions on our ability to model their behaviour. In this project, we will develop a new strategy for computer modelling of polyoxometalates based on the classical molecular mechanics approach and high-level techniques. This novel line of attack will be exploited in the characterization of large and highly substituted derivatives which are key to developing functional materials.Read moreRead less
Unravelling Efficient Nucleic Acid Delivery Using Multilayer Nanoparticles. Developing smarter nanoparticles is critical for maximising the potential of biological therapeutics such as nucleic acids. Currently, the efficiency of nanoparticle delivery remains low due to the inability of carriers to migrate different biological regions. The aim of this project is to develop responsive polymer nanoparticles that can more effectively migrate cell barriers by a two-staged release based on the combina ....Unravelling Efficient Nucleic Acid Delivery Using Multilayer Nanoparticles. Developing smarter nanoparticles is critical for maximising the potential of biological therapeutics such as nucleic acids. Currently, the efficiency of nanoparticle delivery remains low due to the inability of carriers to migrate different biological regions. The aim of this project is to develop responsive polymer nanoparticles that can more effectively migrate cell barriers by a two-staged release based on the combination of different self-immolative polymers. This project will allow the development of design rules for understanding how nanoparticle structure can be optimised to improve nucleic acid delivery. This work will have important benefits such as developing new nanotechnology industry and skilled graduates for Australia.
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Light-Driven Chemistry with Nanostructured Polyanilines. This project seeks to understand and exploit the rich photochemistry for an important class of electrically conducting polymers, namely polyanilines. Light stimulated electron transfer events will be employed in a wide range of exciting applications. The new fundamental knowledge gained will be used to design novel photochemical routes to functionalised polyanilines. The ability to produce solutions, films and especially nanoparticles of p ....Light-Driven Chemistry with Nanostructured Polyanilines. This project seeks to understand and exploit the rich photochemistry for an important class of electrically conducting polymers, namely polyanilines. Light stimulated electron transfer events will be employed in a wide range of exciting applications. The new fundamental knowledge gained will be used to design novel photochemical routes to functionalised polyanilines. The ability to produce solutions, films and especially nanoparticles of polyanilines as photo-catalysts should result in novel light-driven processes of industrial/environmental significance (eg. reduction of carbon dioxide), as well as new light-promoted electronic communication with important biological molecules.Read moreRead less
Developing vitrimers: next generation reusable plastics. This project aims to develop a new class of advanced multifunctional polymer materials with the potential to underpin significant breakthrough capabilities for soft materials in general. The proposed work will relocate biological catalysts from their native, wet environment to solid organic engineering bio-sourced resins. Suitably selected enzymes will allow creation of polymer-based products that can be fully recyclable, with built-in pro ....Developing vitrimers: next generation reusable plastics. This project aims to develop a new class of advanced multifunctional polymer materials with the potential to underpin significant breakthrough capabilities for soft materials in general. The proposed work will relocate biological catalysts from their native, wet environment to solid organic engineering bio-sourced resins. Suitably selected enzymes will allow creation of polymer-based products that can be fully recyclable, with built-in properties such as self-healing, shape morphing, which are mechanically tunable, and have the ability to be reprocessed/recycled multiple times. This research will initiate a disruptive change in the application of biocatalysts for bio-based polymers.Read moreRead less
Controlled Supramolecular Assembly in Aqueous Molecular and Macroscopic Systems. This project uses benign and mainly bio-degradable materials to produce hydrogels which are remarkable new materials containing at least ninety-eight percent water which may be made into films. Similar films are proving to be valuable in covering wounds, particularly serious burns, and in greatly improving wound healing and tissue growth. They may also be useful in new coating and aircraft de-icing technologies. The ....Controlled Supramolecular Assembly in Aqueous Molecular and Macroscopic Systems. This project uses benign and mainly bio-degradable materials to produce hydrogels which are remarkable new materials containing at least ninety-eight percent water which may be made into films. Similar films are proving to be valuable in covering wounds, particularly serious burns, and in greatly improving wound healing and tissue growth. They may also be useful in new coating and aircraft de-icing technologies. These environmentally friendly materials are likely to find a multitude of uses as their development progresses. Young Australians involved in the project will gain experience in cutting edge science, its practical applications, and in international collaboration - a training essential to Australia's future prosperity.Read moreRead less
Light-activated Bioconjugates for Applications in Synthesis and Biosensing. This project will allow the Australian biotechnology industry to develop better diagnostic biosensors that are controlled using light, making them cheaper and faster than the current generation of electronically controlled biosensors. Improvements in the response time of biosensors can be a matter of life and death, for instance, during a surgical operation. The project will benefit the pharmaceutical industry as it will ....Light-activated Bioconjugates for Applications in Synthesis and Biosensing. This project will allow the Australian biotechnology industry to develop better diagnostic biosensors that are controlled using light, making them cheaper and faster than the current generation of electronically controlled biosensors. Improvements in the response time of biosensors can be a matter of life and death, for instance, during a surgical operation. The project will benefit the pharmaceutical industry as it will allow the making of so-called chiral drugs cheaper and safer but problems with the purity of chiral drugs have in the past caused serious side-effects such as in the tragic case of thalidomide.Read moreRead less