Biomarker-driven Applications Of Immunotherapy In Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Immunotherapy is a new treatment strategy that works in many different lymphoma types but there is no successful method of predicting response or selecting patients. I aim to explore use of immunotherapy in 3 key lymphoma subtypes to identify new techniques for predicting which patients respond to treatment through prospective biomarker research using novel techniques. These aims will be achieved through a series of clinical trials of immunotherapy in lymphoma all with a biomarker research focus
Exploring The Role Of The Bcl-2 Family In Haematopoiesis And Haematopoietic Malignancy
Funder
National Health and Medical Research Council
Funding Amount
$190,980.00
Summary
Chronic Lymphocytic Leukaemia and Non-Hodgkin Lymphoma comprise the majority of blood cancers and are both disease in which the cell death pathway plays a vital role in both the development of the cancer cell and the resistance to chemotherapy. This project aims to examine the mechanisms of cancer in these tumours focussing on lymphoid cancers, and examine the role of new treatments targeting this pathway.
Role Of Ferroptosis In The Lipid Metabolism Of Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$238,792.00
Summary
Conventional cancer treatments are becoming increasingly ineffective as cancers mutate to protect cells from drug-activated death. To combat this, new ways to selectively kill cancer cells must be found and therapeutically exploited. This research will study how ferroptosis, a recently discovered form of cell death that is distinct from other killing mechanisms, can be used to target cancer and provide avenues for next-generation cancer treatments.
Developing Mouse Models Of Diffuse Large B Cell Lymphoma For Therapeutic Discovery
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Diffuse large B cell lymphomas are aggressive cancers of white blood cells. Gene mutations play significant yet poorly understood roles in the cause of these lymphomas and their resistance to drug treatments. I plan to develop new mouse models of lymphoma to identify factors that cause lymphoma to develop in living organisms and factors that cause them to resist drug treatment. I will also test if combinations of multiple drugs can effectively and safely treat these lymphomas.
Physiologic And Aberrant DNA Recombination In B Lymphocytes
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
B cells produce antibody which is critical to fight infection. In order to perform this function, antibody genes must first be modified by immune enzymes. However, abnormal DNA attack by these enzymes outside of antibody genes can result in B cell cancer. How the immune system detects and destroys cancerous B cells is poorly understood. This research will provide insight into these processes, and in doing so will further our understanding of how B cell cancers develop and how they are destroyed.
T-cells: The Key To Unlocking Immunity Against Aggressive Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$322,951.00
Summary
By investigating several aspects of patients’ immune defenses against the cancer cells in Diffuse large B-cell lymphoma, this project will provide critical insights on ways to harness the patient’s own immune system to effectively mount anti-tumour responses. These results will pave the way for future therapeutic strategies to successfully treat and prevent lymphoma.
Cell Pedigree Tracking To Elucidate How Polarity Proteins Alter Fate In B-cell Development And Leukaemia.
Funder
National Health and Medical Research Council
Funding Amount
$307,946.00
Summary
During the onset of cancer, the orientation of cells is lost. My research project aims to determine the cellular and molecular basis by which proteins responsible for the orientation of cells are involved in leukaemia. Additionally, my work will investigate whether or not all proteins are equally distributed during cell division in B cell development, and will provide a platform for further investigation into how protein distribution might orchestrate fate decisions during development and leukae ....During the onset of cancer, the orientation of cells is lost. My research project aims to determine the cellular and molecular basis by which proteins responsible for the orientation of cells are involved in leukaemia. Additionally, my work will investigate whether or not all proteins are equally distributed during cell division in B cell development, and will provide a platform for further investigation into how protein distribution might orchestrate fate decisions during development and leukaemia.Read moreRead less
Investigation Of Unique Immune Microenvironment Of Primary CNS Lymphoma
Funder
National Health and Medical Research Council
Funding Amount
$265,138.00
Summary
This study will investigate how the immune system responds to the development of brain lymphoma. It is expected that this lymphoma develops due to a defective immune response. It is unknown why the tumour is so effective at evading the immune response but if the hypothesis is correct, then the application of new drugs that stimulate the immune system to attack the lymphoma could lead to a marked improvement in survival without the need for toxic chemotherapy and radiation.