I am an immunologist-cell biologist investigating the regulation of human immune responses in health and disease. The overall goal of this work is to improve immunity in individuals with immunodeficiencies, or during vaccination, or to attenuate immune re
The Australia Fellowship will enable Prof Good to pursue the development of vaccines for two major pathogens – malaria and group A streptococcus (GAS). Both research programs are entering exciting phases as we move into Phase I clinical trials. At the same time, the Fellowship will enable us to explore the development of the next generation vaccine candidates for these diseases. Malaria is responsible for approximately 1 million deaths per year, mainly of children under 5 years of age, while dis ....The Australia Fellowship will enable Prof Good to pursue the development of vaccines for two major pathogens – malaria and group A streptococcus (GAS). Both research programs are entering exciting phases as we move into Phase I clinical trials. At the same time, the Fellowship will enable us to explore the development of the next generation vaccine candidates for these diseases. Malaria is responsible for approximately 1 million deaths per year, mainly of children under 5 years of age, while diseases caused by group A streptococcus (such as rheumatic heart disease [RHD] and RHD-related stroke) are responsible for at least 500,000 deaths per year. Australia’s Indigenous population suffer the highest documented rate of RHD in the world. We have strong international support and collaboration for these vaccine research programs and have approached the US FDA for a license to conduct the trial for a GAS vaccine and will soon approach them for a licence to undertake the malaria vaccine trial.Read moreRead less
Prof Carbone’s laboratory specialises in the study of immunity at the body surfaces. These surfaces include skin and mucosal tissues such as respiratory and gastrointestinal tract, all of which are the common points of entry for a variety of infectious agents. He has found that there exist cells at these peripheral sites that are separate from the immune components that one finds in the blood and, more importantly, that provide a profound level of protection during new infection. He now propose ....Prof Carbone’s laboratory specialises in the study of immunity at the body surfaces. These surfaces include skin and mucosal tissues such as respiratory and gastrointestinal tract, all of which are the common points of entry for a variety of infectious agents. He has found that there exist cells at these peripheral sites that are separate from the immune components that one finds in the blood and, more importantly, that provide a profound level of protection during new infection. He now propose to determine how best to induce this type of peripheral immune protection and how one can exploit these mechanisms for the purpose of infection control.Read moreRead less
I am a stem cell scientist working on the biology of human embryonic stem cells and their differentiation into cells of mesodermal (blood, endothelium and cardiomyocyte) and endodermal (pancreatic islet cells) lineages.
Through the Australia Fellowship Prof Mattick will lead a team of researchers to explore the scientific and applied dimensions of the thesis that the human genome is not largely comprised of evolutionary debris, but encodes an extraordinarily sophisticated information suite that is largely transacted by RNA. The work will include examination of the expression patterns on noncoding RNAs in different tissues and cells and different disease states, exploration of the location and dynamics of RNAs a ....Through the Australia Fellowship Prof Mattick will lead a team of researchers to explore the scientific and applied dimensions of the thesis that the human genome is not largely comprised of evolutionary debris, but encodes an extraordinarily sophisticated information suite that is largely transacted by RNA. The work will include examination of the expression patterns on noncoding RNAs in different tissues and cells and different disease states, exploration of the location and dynamics of RNAs associated with DNA and various proteins to determine how these RNAs influence gene expression, targeted functional analyses of selected subsets of these RNAs to determine their biological function as proof-of-principle for others, exploration of the roles of RNA editing proteins, and testing of the hypothesis that RNA-directed DNA recoding might underpin memory formation. If correct, the results of the project will transform our understanding of human biology, development, and brain function, and create an enlightened framework for future research into human health and disease.Read moreRead less