From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Predicting biodiversity distribution on the Antarctic continental shelf. This project aims to develop an international database of underwater observations to predict the distribution of seafloor biodiversity over the entire Antarctic continental shelf for the present day and to 2100. Antarctic seafloor communities are unique and highly diverse, but their distribution is poorly known because biological data are sparse. These predictions depend on a unique and validated approach to estimate the pr ....Predicting biodiversity distribution on the Antarctic continental shelf. This project aims to develop an international database of underwater observations to predict the distribution of seafloor biodiversity over the entire Antarctic continental shelf for the present day and to 2100. Antarctic seafloor communities are unique and highly diverse, but their distribution is poorly known because biological data are sparse. These predictions depend on a unique and validated approach to estimate the present and future redistribution of surface primary production to the seafloor, and will enable calculating the amount of atmospheric carbon captured and stored at the seafloor. The maps will be at an unprecedented resolution of around 2 kilometres, and be invaluable tools underpinning policy, management and future science.Read moreRead less
Universal properties and application of species size distributions. This project aims to identify general properties of body size distributions for thousands of aquatic species by bringing together datasets enabled by global observation and citizen science programs, novel statistical methods and latest theoretical advances. By addressing temperature effects on body sizes, the project expects to generate new knowledge about species status globally, under the combined impacts of climate change and ....Universal properties and application of species size distributions. This project aims to identify general properties of body size distributions for thousands of aquatic species by bringing together datasets enabled by global observation and citizen science programs, novel statistical methods and latest theoretical advances. By addressing temperature effects on body sizes, the project expects to generate new knowledge about species status globally, under the combined impacts of climate change and harvesting. Expected outcomes include new tools to integrate limited body size data into a consistent framework for significance advancement of models used in research and management. This should increase the capacity to assess human impacts on natural ecosystems and predict global warming driven changes.Read moreRead less
The contribution of human/marine herbivore interactions to reef degradation. This project aims to define how interactions between human society and herbivores influence marine ecosystem structure and function. It will analyse geographic patterns from recent systematic sampling of reef communities worldwide and study fish, macro-invertebrate and meso-grazer herbivory to identify herbivores’ role in the collapse and recovery of reef ecosystems. This project will examine the match between a critica ....The contribution of human/marine herbivore interactions to reef degradation. This project aims to define how interactions between human society and herbivores influence marine ecosystem structure and function. It will analyse geographic patterns from recent systematic sampling of reef communities worldwide and study fish, macro-invertebrate and meso-grazer herbivory to identify herbivores’ role in the collapse and recovery of reef ecosystems. This project will examine the match between a critical ecosystem function and community structure across local to global scales, including the identification of non-linearities and interactions involving human effects on this process. This research is expected to safeguard marine ecosystems from collapse.Read moreRead less
Utilising plant-sediment-feedbacks to enhance seagrass restoration. This project aims to investigate the role of sediment microbes in promoting the health of threatened seagrass species across Australia. This project expects to create new knowledge for enhancing restoration success for seagrasses by integrating macro and micro-ecology, environmental genomics, plant ecology and ecosystem function (e.g. nutrient and biogeochemistry cycling). Expected outcomes are new knowledge to enhance seagrass ....Utilising plant-sediment-feedbacks to enhance seagrass restoration. This project aims to investigate the role of sediment microbes in promoting the health of threatened seagrass species across Australia. This project expects to create new knowledge for enhancing restoration success for seagrasses by integrating macro and micro-ecology, environmental genomics, plant ecology and ecosystem function (e.g. nutrient and biogeochemistry cycling). Expected outcomes are new knowledge to enhance seagrass restoration utilising sediment microbes that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of seagrasses, and the ecosystem services, and economic and social benefits they provide.Read moreRead less
Improved electrophoretic analyser for water quality monitoring. This proposal will advance the Australian made Eco Detection portable electrophoretic analyser for autonomous monitoring of water chemistry - the Eco Sensor. We will re-design and miniaturise the fluidic manifold to reduce capital- and per-sample cost, increase the sensitivity of nutrients - nitrate and phospate - by 100-times in both fresh- and sea-waters, and develop new ultra-sensitive reagents for heavy metal detection at enviro ....Improved electrophoretic analyser for water quality monitoring. This proposal will advance the Australian made Eco Detection portable electrophoretic analyser for autonomous monitoring of water chemistry - the Eco Sensor. We will re-design and miniaturise the fluidic manifold to reduce capital- and per-sample cost, increase the sensitivity of nutrients - nitrate and phospate - by 100-times in both fresh- and sea-waters, and develop new ultra-sensitive reagents for heavy metal detection at environmentally regulated levels. This will provide a single platform for at-site near-real-time monitoring of water chemistry for agricultural, mining, water corporations and other industries that use and/or discharge water to the environment. Read moreRead less
How does forestry impact headwater streams? Although headwater streams make up much of the catchment of rivers, the effects of forestry on instream species composition, habitat types, and ecosystem functions remain uninvestigated. We aim to fill these three gaps so that managers can: 1. determine whether stream side buffers are necessary and 2. identify which species and ecosystem functions are the most sensitive and reliable variables for future monitoring of instream ecosystem health.
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less
Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100019
Funder
Australian Research Council
Funding Amount
$580,000.00
Summary
A transportable containerised laboratory for rapid cell sorting and high-resolution bioimaging of living aquatic microbes in field locations. This project will deliver a transportable, unique laboratory for the rapid isolation and high-resolution analysis of living microbes immediately after sampling from the sea or waterways. It will be the first of its kind in Australia and deliver new knowledge of the role of these organisms in their natural habitats.