Ecosystem risk assessment. This project aims to develop a type-based framework for the world's ecosystems, and undertake the first broad-scale global risk assessment for ecosystems. It will include detailed Australian risk assessments and scenario analyses to develop sustainable management of ecosystem services and climate adaptation strategies. The outcomes include a global-scale framework for classifying terrestrial, freshwater and marine ecosystems, the first global Red List of Ecosystems and ....Ecosystem risk assessment. This project aims to develop a type-based framework for the world's ecosystems, and undertake the first broad-scale global risk assessment for ecosystems. It will include detailed Australian risk assessments and scenario analyses to develop sustainable management of ecosystem services and climate adaptation strategies. The outcomes include a global-scale framework for classifying terrestrial, freshwater and marine ecosystems, the first global Red List of Ecosystems and identified priorities for protecting remaining wild ecosystems and restoring those that have suffered degradation. This will help meet UN Sustainable Development Goals to improve human well-being globally.Read moreRead less
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Assessing the ecosystem-wide risks of threatened species translocation. Assessing the ecosystem-wide risks of threatened species translocation. This project aims to develop the first quantitative risk assessment framework to improve decisions about moving threatened species to new places. Moving threatened plants and animals to new environments, or reintroducing them where they previously persisted, is a growing focus of conservation. Moving species can have unanticipated effects on other specie ....Assessing the ecosystem-wide risks of threatened species translocation. Assessing the ecosystem-wide risks of threatened species translocation. This project aims to develop the first quantitative risk assessment framework to improve decisions about moving threatened species to new places. Moving threatened plants and animals to new environments, or reintroducing them where they previously persisted, is a growing focus of conservation. Moving species can have unanticipated effects on other species in the ecosystem. Although the International Union for Conservation of Nature deems ecosystem-wide risk assessments essential for conservation translocations, no framework exists to assess these risks and inform these decisions. New tools for assessing the risks of conservation translocations are expected to improve global and local conservation outcomes.Read moreRead less
Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
Ecological valuation tools to protect seagrass during coastal development. Ecological valuation tools to protect seagrass during coastal development. Focussing on differences between shallow and deep seagrasses in the Great Barrier Reef, this project aims to develop a spatial valuation tool so resource managers and policy makers can minimise the effect of port development on seagrass ecosystems. Seagrasses provide ecosystem services (fisheries, nutrient cycling, primary productivity) worth trill ....Ecological valuation tools to protect seagrass during coastal development. Ecological valuation tools to protect seagrass during coastal development. Focussing on differences between shallow and deep seagrasses in the Great Barrier Reef, this project aims to develop a spatial valuation tool so resource managers and policy makers can minimise the effect of port development on seagrass ecosystems. Seagrasses provide ecosystem services (fisheries, nutrient cycling, primary productivity) worth trillions of dollars, but coastal development threatens this capacity. Resource managers lack accurate information about their potential effect and mitigation measures. Anticipated outcomes are protection of key marine environment and World Heritage Assets, and benefits to Australia’s economy through maintenance of ecosystem services and reduced risk associated with development.Read moreRead less
Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster re ....Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster reef restoration that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of estuaries, and reestablish the environmental, economic and social benefits of oyster reefs.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100441
Funder
Australian Research Council
Funding Amount
$474,443.00
Summary
Sounds of change: using ecological knowledge to advance acoustic monitoring. To recover biodiversity, conservation actions must be informed by robust ecological data. In partnership with Bush Heritage Australia, this project aims to transform ecological monitoring with eco-acoustic technologies by developing new acoustic metrics to measure biodiversity at various levels, from individual species through to whole communities. This project will combine advanced computer methods with theories of ani ....Sounds of change: using ecological knowledge to advance acoustic monitoring. To recover biodiversity, conservation actions must be informed by robust ecological data. In partnership with Bush Heritage Australia, this project aims to transform ecological monitoring with eco-acoustic technologies by developing new acoustic metrics to measure biodiversity at various levels, from individual species through to whole communities. This project will combine advanced computer methods with theories of animal sounds and communities to generate metrics that are informed by animal ecology and directly address monitoring needs of conservation organisations. By experimentally testing the metrics on long-duration real-world sound data, this project will provide new tools to measure conservation impact and prioritise actions.Read moreRead less
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
From prediction to adaptation: responding to rapid ecosystem shifts under climate change. Nobody knows exactly how climate change will affect the ecosystems on which we depend for our own existence, though negative impacts are widely predicted. This project integrates mathematical, economic and ecological approaches to learn about the most effective way to spend limited funds for sustaining ecosystems threatened by climate change.
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less