Benefit Of 2D-strain Surveillance In Improving Cardiovascular Outcomes In Cancer Patients Undergoing Cardiotoxic Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$2,391,979.00
Summary
Cancer survivors are susceptible to heart failure (HF) caused by heart muscle damage from chemotherapy. The current testing for this problem is based on a measure that cannot identify minor changes of cardiac function. Cardiac strain is a sensitive new marker of cardiac function which is predictive of overt dysfunction & HF. This study seeks to identify whether strain can be used to assign treatments that lead to improved cardiac function and are eventually associated with a reduction in HF.
Ecosystem risk assessment. This project aims to develop a type-based framework for the world's ecosystems, and undertake the first broad-scale global risk assessment for ecosystems. It will include detailed Australian risk assessments and scenario analyses to develop sustainable management of ecosystem services and climate adaptation strategies. The outcomes include a global-scale framework for classifying terrestrial, freshwater and marine ecosystems, the first global Red List of Ecosystems and ....Ecosystem risk assessment. This project aims to develop a type-based framework for the world's ecosystems, and undertake the first broad-scale global risk assessment for ecosystems. It will include detailed Australian risk assessments and scenario analyses to develop sustainable management of ecosystem services and climate adaptation strategies. The outcomes include a global-scale framework for classifying terrestrial, freshwater and marine ecosystems, the first global Red List of Ecosystems and identified priorities for protecting remaining wild ecosystems and restoring those that have suffered degradation. This will help meet UN Sustainable Development Goals to improve human well-being globally.Read moreRead less
Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size dis ....Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size distributions from tropical to polar environments are expected to reveal these vital rates of pelagic ecosystems. The zooplankton rates will reveal, for the first time, the link between phytoplankton and fisheries, and will significantly improve ecosystem models and global assessments of environmental change.Read moreRead less
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling ....Unravelling the drivers of greenhouse gas emissions in estuaries. The aim of this project is to understand and quantify the factors controlling the emission of carbon dioxide, methane and nitrous oxide from estuaries. Coastal systems play a disproportionately large role in the global emissions of greenhouse gases, but this is poorly quantified. The project plans to use a combination of continuous concentration and stable isotope measurements, process measurements and advanced numerical modelling across a range of undisturbed to disturbed systems. It is intended that this project will provide information for conceptualising, calibrating and verifying models, including green-house gas production. Good models, and the data that support them, such as that provided by this study, are critical for the efficient allocation of management resources in Australian coastal systems, including by our partners. The findings from this project will have direct implications to the management, rehabilitation and protection of waterways (including biodiversity) in Australia.Read moreRead less
Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will b ....Investigating movement, distribution, abundance and diet to support management objectives for threatened riverine predators in Northern Australia. The rivers and estuaries of northern Australia are highly productive environments, containing an exceptional diversity and abundance of large predatory aquatic species. This project aims to monitor the movements, habitat preferences and diet in eight large predatory species in a northern Queensland river over the next three years. Movement data will be combined with isotopic analysis to reveal how environmental and biological factors drive animal movements and impact habitat connectivity. In a world of vanishing top predators, it is imperative to understand system dynamics before we can evaluate the impact of species removal on ecosystem function.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101424
Funder
Australian Research Council
Funding Amount
$425,469.00
Summary
Conservation agriculture for aquatic wildlife in dams and wetlands. This project aims to investigate the capacity of farm dam management strategies to simultaneously support nature conservation and agricultural production. The project expects to generate new knowledge in the areas of conservation biology and sustainable agriculture by using experiments that identify the interdependence of cattle grazing and habitat quality of wetlands. Anticipated outcomes include a framework for evaluating mana ....Conservation agriculture for aquatic wildlife in dams and wetlands. This project aims to investigate the capacity of farm dam management strategies to simultaneously support nature conservation and agricultural production. The project expects to generate new knowledge in the areas of conservation biology and sustainable agriculture by using experiments that identify the interdependence of cattle grazing and habitat quality of wetlands. Anticipated outcomes include a framework for evaluating management strategies in terms of their dual capacity to support aquatic wildlife and livestock production. Significant benefits include increased productivity through the improved management of wetlands and dams on farms and the recogniton of undervalued conservation resources.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster re ....Developing a framework for effective oyster reef restoration. This project aims to investigate ecological barriers to the recovery of functionally extinct Sydney Rock Oyster reefs on Australia’s east coast, and restoration methods to reinstate their key ecosystem services. This project expects to create new knowledge for designing functional reefs by integrating physiology, population, community and landscape ecology. Expected outcomes are an ecological decision framework for effective oyster reef restoration that can be integrated into management and policy. This project should provide significant benefits, such as the development of key strategic alliances to enhance management of estuaries, and reestablish the environmental, economic and social benefits of oyster reefs.Read moreRead less
Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less