Risk Assessment And Prevention Of Respiratory Complications In Paediatric Anaesthesia
Funder
National Health and Medical Research Council
Funding Amount
$494,253.00
Summary
Respiratory problems account for more than three quarters of all critical incidents and a third of all cardiac arrests in healthy children undergoing anaesthesia for surgical procedures. It is therefore vital to identify high risk children early to be able to adapt the anaesthesia regimen accordingly. This series of studies will study new prediction and prevention strategies to minimise respiratory problems and therefore improve the safety for our children when undergoing anaesthesia.
Inhibition Of Allergic Airway Inflammation By Nanoparticles
Funder
National Health and Medical Research Council
Funding Amount
$540,075.00
Summary
Inhaled air pollution particulate matter causes asthma exacerbations, with 'ultrafine' nanoparticles thought to play a major role. Unexpectedly, we recently found that, by contrast, administration of inert ultrafine nanoparticles prevents allergic airway inflammation. We will identify the key particle physical and chemical properties associated with this novel type of disease inhibition, study particle effects in clinically-relevant disease models and identify mechanisms of action.