The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Gastroduodenal Motility And Glycaemic Control In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$393,750.00
Summary
The recent application of novel techniques to evaluate gastrointestinal motor function has established that the rate which the stomach empties food is abnormally slow in ~50% of people who have insulin-dependent (type 1) or non-insulin dependent (type 2) diabetes. Delayed stomach emptying was thought to be an infrequent complication in diabetes; much less common than damage to the eyes, kidneys or nerves. Abnormal stomach emptying may contribute to a number of problems in diabetes, including sym ....The recent application of novel techniques to evaluate gastrointestinal motor function has established that the rate which the stomach empties food is abnormally slow in ~50% of people who have insulin-dependent (type 1) or non-insulin dependent (type 2) diabetes. Delayed stomach emptying was thought to be an infrequent complication in diabetes; much less common than damage to the eyes, kidneys or nerves. Abnormal stomach emptying may contribute to a number of problems in diabetes, including symptoms such as nausea and bloating, and poor control of blood glucose concentrations. It is now recognised that the blood glucose level itself has a reversible effect on both stomach contractions and symptoms. For example, when the blood glucose is abnormally high (hyperglycaemia), the rate at which the stomach empties food into the intestine is slower and symptoms, such as fullness, are greater. The rate of stomach emptying and the absorption of glucose from the intestine affect the rise in the blood glucose level after a meal; this is an important issue because it is desirable to maintain blood glucose levels within the normal range to minimise the risk of both the development and progression of the complications of diabetes. In many people with diabetes eating a meal results in a substantial fall in blood pressure, which may cause fainting and falls. By slowing gastric emptying the magnitude of the fall in blood pressure is minimised. Our group has been the recipient of ongoing support from the NH and MRC for approximately 18 years to conduct research in this area. As a result we have performed the most comprehensive studies to date and developed new methods to evaluate stomach and intestinal function in people with diabetes, resulting in international recognition. The studies proposed in the current application represent a logical development from our previous work and have important implications for the management of diabetes.Read moreRead less
Gastric Motility And Blood Glucose Control In Diabetes Mellitus
Funder
National Health and Medical Research Council
Funding Amount
$354,947.00
Summary
The recent application of novel techniques to evaluate gastrointestinal motor function has established that the rate of which the stomach empties food is slow in up to 50% of people who have insulin-dependent (type 1) or non-insulin dependent (type 2) diabetes. Delayed stomach emptying was thought to be an infrequent complication in diabetes; much less common than damage to the eyes, kidneys or nerves. It is now recognised that disordered stomach emptying may contribute to a number of problems i ....The recent application of novel techniques to evaluate gastrointestinal motor function has established that the rate of which the stomach empties food is slow in up to 50% of people who have insulin-dependent (type 1) or non-insulin dependent (type 2) diabetes. Delayed stomach emptying was thought to be an infrequent complication in diabetes; much less common than damage to the eyes, kidneys or nerves. It is now recognised that disordered stomach emptying may contribute to a number of problems in diabetes, e.g. symptoms such as nausea and bloating and poor control of blood glucose concentrations. In some people symptoms are disabling and affect quality of life adversely. The effects of stomach emptying on blood glucose control is likely to be important, as it is desirable to maintain blood glucose levels within the normal range to minimise the risk of both the development and progression of complications of diabetes. In many people with diabetes, particularly older people with type 2 diabetes, there is a fall in blood pressure after a meal which may result in fainting and falls. The magnitude of the fall in blood pressure is determined by the rate at which the stomach empties; faster emptying results in a greater fall in blood pressure. In the past both slow stomach emptying and symptoms were assumed to result from irreversible nerve damage, however it is now recognised that the blood glucose level itself has a reversible effect on both stomach contractions and symptoms. Our group has been the recipient of ongoing support from the NH and MRC for approximately 15 years to conduct research in this area. As a result we have performed the most comprehensive studies to date and developed new methods to evaluate stomach function in people with diabetes, resulting in international recognition. The studies proposed in this current application represent a logical development from our previous work and have important implications for the management of diabetes.Read moreRead less
Relationships Between Diet And Gastric Motor Function In Functional Dyspepsia
Funder
National Health and Medical Research Council
Funding Amount
$220,500.00
Summary
Functional dyspepsia (FD) is a condition characterised by abdominal symptoms without a cause that is identifiable by conventional diagnostic tests. Symptoms (eg fullness, bloating) are frequently induced by eating. 20 - 40 % of the adult population in Western countries are affected by FD, and the condition, therefore, represents a considerable financial burden to the health care system. FD affects quality of life adversely. In many people with FD, stomach contractions and the 'sensitivity' of th ....Functional dyspepsia (FD) is a condition characterised by abdominal symptoms without a cause that is identifiable by conventional diagnostic tests. Symptoms (eg fullness, bloating) are frequently induced by eating. 20 - 40 % of the adult population in Western countries are affected by FD, and the condition, therefore, represents a considerable financial burden to the health care system. FD affects quality of life adversely. In many people with FD, stomach contractions and the 'sensitivity' of the stomach are abnormal. Often, people with FD avoid fatty foods in the belief that these cause or exacerbate symptoms. There is, however, little information about the potential role of dietary habits in causing symptoms, the relationship between eating and disturbances in stomach function, and the impact of dietary changes on symptoms. Our previous studies suggest an important role for nutrients, particularly fat, in FD. We will address the hypothesis that dietary factors, particularly fat intake, have substantial implications for the pathophysiology and treatment of FD. Our studies will involve physiological (stomach emptying, appetite and food intake) and epidemiological (dietary habits, dyspeptic symptoms and quality of life-related aspects) measurements. The subjects-patients with FD will receive standardised test meals of varying nutrient composition, and we will study the effects on their stomach and on symptoms. We will also test some medications in an attempt to alleviate symptoms during and after food ingestion, particularly after fatty foods. Other studies will assess the dietary habits of patients with FD in relation to symptom occurrence and investigate the possibility that dietary intervention (reduction of fat content in the diet, exclusion of offending foods) will benefit these patients. The proposed studies will provide the most comprehensive studies to date of the relationship between symptoms in patients with FD with dietary habits and stomach function.Read moreRead less