Preconception Determinants Of Child Health And Development: A 4-year Follow Up Of Offspring Born To The Australian Temperament Project
Funder
National Health and Medical Research Council
Funding Amount
$1,065,799.00
Summary
This project will follow offspring born to a large population cohort study that has tracked the mental health and wellbeing of around 2000 participants across 30 years prior to parenthood. The aim is to understand how the lives parents lived before conception, as well as events during pregnancy, shape social and emotional outcomes for their children. Results will inform radically new approaches to promoting child health and development across generations.
The RADAR Project: Identifying Early Warning Signals On The Pathways To Alcohol Use Disorder
Funder
National Health and Medical Research Council
Funding Amount
$884,321.00
Summary
The transition from alcohol initiation to an alcohol use disorder is a crucial yet under-studied research area. The current project will characterise the natural history of alcohol use disorder and identify modifiable factors that increase or decrease the likelihood of developing an alcohol use disorder once alcohol use begins. This information will guide prevention of, and early intervention for, this disabling disorder.
What Are The Lifetime Clinical Predictors And Risk Factors For Multiple Phenotypes Of Adult Asthma, COPD And Sleep Disordered Breathing? Following Up The TAHS Cohort From 1st To 6th Decade
Funder
National Health and Medical Research Council
Funding Amount
$1,950,689.00
Summary
Breathing gets impaired and impact on the productivity and quality of life when chronic respiratory diseases rise with ageing. Adult chronic respiratory diseases are major causes of illness and death but there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will provide evidence to guide health policy and clinical management of these diseases. These original findings will be of great importance both nationally and internationally.
Quantifying The Effectiveness Of Pertussis Vaccine In Older Adults
Funder
National Health and Medical Research Council
Funding Amount
$448,703.00
Summary
Pertussis is the most poorly controlled vaccine preventable disease in Australia. Childhood pertussis is a well-known public health problem but adult pertussis is also common and has a significant burden on the health system, especially in adults over 65 years. Pertussis vaccines for adults are currently not funded by our national immunisation program. This project will provide vital data to inform whether pertussis vaccination is cost-effective in older Australian adults.
Generational And Developmental Pathways Of Childhood And Adolescent Obesity: A Three Generation Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,281,100.00
Summary
There are no community-based follow-up (FU) studies of three generations able to examine the impact of earlier generational factors on the developmental pathways of obesity in third generation. The Mater-University of Queensland Study of Pregnancy (MUSP) cohort now has data covering the grandmothers' (GI) reproductive life course and a FU of their children (GII) into adulthood. We now propose a new study of the "children-of-the-children" who are the grandchildren (GIII) of GI and children of GII
Risks And Benefits Of Breast Cancer Screening: BreastScreen WA Cohort Study Of Overdiagnosis And Breast Cancer Mortality
Funder
National Health and Medical Research Council
Funding Amount
$201,524.00
Summary
Overdiagnosis is the major downside of screening for breast cancer. This occurs when screening detects cancers that would not have caused symptoms in the woman's lifetime. This study aims to quantify the amount of overdiagnosis that occurs in the Australian breast cancer screening program (BreastScreen)
DNA Methylation As A Risk Factor For Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$780,185.00
Summary
Methylation of DNA involves a change to the chemical composition of DNA. It can affect the function of genes and normal methylation is essential for life. Aberrant methylation is associated with many diseases, including colorectal cancer. In this grant, we will explore whether aberrant methylation of DNA obtained from the blood can predict the risk of colorectal cancer. Our ultimate aim is to better identify people at higher risk of cancer.
Improving Outcomes From Ovarian Cancer: Building The Evidence To Help Women Help Themselves
Funder
National Health and Medical Research Council
Funding Amount
$1,839,772.00
Summary
Ovarian cancer affects 1300 women each year in Australia and 5-year survival is <45%. Women with this cancer thus face a poor prognosis and many ask what they can do to improve this. There is no direct evidence whether a woman’s lifestyle might influence her outcomes, although data from breast cancer suggest this is possible. The OPAL Study will follow 1200 women with ovarian cancer to identify whether lifestyle is associated with survival to provide guidance for women with this disease.
The Predictors Of Asthma And Lung Function Deficits In The Third Decade: Longitudinal Study Of MACS Sibships
Funder
National Health and Medical Research Council
Funding Amount
$1,176,908.00
Summary
This will be the world’s first birth cohort study to use substantial prospective data to investigate how biological, psychosocial, and environmental markers from birth will predict asthma and lung function in the third decade of life. Our findings will be crucial to the development of new policy and practice for the prevention and management of these conditions and uncover crucial risk factors for young adult asthma.
Risk Factors For Food Allergy And The Allergic March To Asthma In Childhood: The HealthNuts Study
Funder
National Health and Medical Research Council
Funding Amount
$1,876,796.00
Summary
Food allergy appears to represent a second epidemic of allergic disease. It is not known why some children grow out of their food allergy or how food allergy in the first year of life impacts asthma and allergy in later childhood. HealthNuts is a large study of 5300 children that can answer these questions. HealthNuts visited children at ages 1, 4 and 6 and requests funding to re-visit them at age 10. Results will help prevent children developing food allergy, asthma and the allergic march.