Perinatal Outcomes Following Treatment For Cervical Dysplasia
Funder
National Health and Medical Research Council
Funding Amount
$98,600.00
Summary
A very high proportion of women in Australia have regular cervical screening ('pap' tests) for early detection of any early abnormal changes of the cervix. Women with abnormalities are referred for further investigation and some go on to have the areas with abnormalities treated either by surgical removal of small amounts of tissue or by other heat or laser treatments of affected areas. Many women having these treatments are of child-bearing age and may not have had children, or may seek to have ....A very high proportion of women in Australia have regular cervical screening ('pap' tests) for early detection of any early abnormal changes of the cervix. Women with abnormalities are referred for further investigation and some go on to have the areas with abnormalities treated either by surgical removal of small amounts of tissue or by other heat or laser treatments of affected areas. Many women having these treatments are of child-bearing age and may not have had children, or may seek to have more children after treatment. There are unanswered questions about the extent to which any or all of these treatments might, by changes to the cervix, lead to preterm birth in any subsequent pregnancy. In the proposed study, records relating to women referred from 1982 to 2000 for assessment and possible treatment of cervical abnormalities at a major hospital will be linked to Victorian birth records from 1983 to 2001. This will allow a comparison of preterm birth in the group of women referred with cervical abnormalities, with preterm births in the Victorian population, and comparing women who do and don't have treatment, taking into account other important factors such as the mother's age, and her previous pregnancies. The information will be of value to women themselves, to gynaecologists and to screening services.Read moreRead less
Thai Health-risk Transition: A National Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$1,231,214.00
Summary
Thailand's disease patterns are changing. Some changes are good but others, like emerging diabetes, heart disease and injuries, are of concern. Development-related 'health transition' can be optimised if there is information on new causes of disease - immediate risk factors, and 'upstream' economic, cultural and environmental influences. The team will study this health-risk transition in the whole Thai population - looking back 50 years, then forwards in 100,000 Sukothai Thammathirat Open Univer ....Thailand's disease patterns are changing. Some changes are good but others, like emerging diabetes, heart disease and injuries, are of concern. Development-related 'health transition' can be optimised if there is information on new causes of disease - immediate risk factors, and 'upstream' economic, cultural and environmental influences. The team will study this health-risk transition in the whole Thai population - looking back 50 years, then forwards in 100,000 Sukothai Thammathirat Open University students living all over Thailand and followed for four years. The team will map changing risks and upstream influences, produce information for Thai preventive programs, boost regional research capacity, create a regional partnership, and support PhD and postdoctoral training.Read moreRead less
Preterm birth, a birth before the 37th week of pregnancy occurs for fewer than 8% of mothers but is associated with two-thirds of all fetal deaths and deaths of liveborn infants in the first month after birth. In the late 1990s those deaths are concentrated among very preterm births i.e. births before the 32nd week of pregnancy. Infants born very preterm are very likely to need neonatal intensive care, quite likely to have had major respiratory, infectious or other problems after birth, and to n ....Preterm birth, a birth before the 37th week of pregnancy occurs for fewer than 8% of mothers but is associated with two-thirds of all fetal deaths and deaths of liveborn infants in the first month after birth. In the late 1990s those deaths are concentrated among very preterm births i.e. births before the 32nd week of pregnancy. Infants born very preterm are very likely to need neonatal intensive care, quite likely to have had major respiratory, infectious or other problems after birth, and to need readmission to hospital in the first year after birth. Surviving infants are more likely to have major impairments, minor impairments, and school difficulties than infants born at term. There is a substantial impact on families, health services and society of very preterm birth.There has been no reduction in the proportion of births which are preterm, or very preterm in the last 20 years, though advances in treatment and care have markedly improved the survival of preterm and very preterm infants. This study will investigate the role of previous pregnancies which did not result in births (miscarriages and terminations), together with other procedures such as D and C (dilatation and curettage), in subsequent preterm birth. As these previous pregnancy losses are all fairly common experiences any associated risk is important and this particular factor has not been studied in this way before. There is preliminary evidence that they may be associated with preterm birth and the study will be able to measure the associations while taking into account all the other known risk factors. Other possible risk factors such as experiencing violence in pregnancy or social factors acting at a neighbourhood level will also be included. If it is found that previous pregnancy losses are independently associated with preterm birth it will be possible to develop and test preventive strategies.Read moreRead less
Methodology For Population Health Research: Training And Innovation In Longitudinal Studies
Funder
National Health and Medical Research Council
Funding Amount
$1,963,750.00
Summary
This proposal builds on the applicants' experience with existing cohort studies to identify, evaluate and address areas of methodological concern, particularly with longitudinal studies. The group's ability to develop robust longitudinal methods in relation to these concerns will have the potential for both increasing knowledge of the determinants of population health and increasing their ability to attract trainee biostatisticians, an identified area of need in the country as a whole. The grant ....This proposal builds on the applicants' experience with existing cohort studies to identify, evaluate and address areas of methodological concern, particularly with longitudinal studies. The group's ability to develop robust longitudinal methods in relation to these concerns will have the potential for both increasing knowledge of the determinants of population health and increasing their ability to attract trainee biostatisticians, an identified area of need in the country as a whole. The grant will help position Australia at the cutting edge of research skills and methodology involved with longitudinal studies. Longitudinal studies provide a powerful means of collecting information about the health of populations. This grant will use multi-disciplinary approaches to develop innovative methods for designing longitudinal studies, collecting and analysing data and communicating results to improve people's health.Read moreRead less
Psychosocial Disorders Of Youth: A Population-based Prospective Study Into Young Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$450,939.00
Summary
Much earlier work in adults has pointed to the teens as a common point at which many of the important causes of chronic disease and disability in adults begin. These include problems such as tobacco use, depression and anxiety disorders, obesity, alcohol abuse and illicit drug use. However, only a prospective study is able to clarify to what extent common health risk behaviours of teenagers pose a threat to later health and well-being and what characteristics indicate those most likely to go on ....Much earlier work in adults has pointed to the teens as a common point at which many of the important causes of chronic disease and disability in adults begin. These include problems such as tobacco use, depression and anxiety disorders, obesity, alcohol abuse and illicit drug use. However, only a prospective study is able to clarify to what extent common health risk behaviours of teenagers pose a threat to later health and well-being and what characteristics indicate those most likely to go on to problems such as nicotine dependence, recurrent depression and illicit drug abuse. The proposal deals with the follow-up ten years on of a representative sample of 2000 Victorian teenagers. Seven earlier waves of data collections have ascertained levels and risk factors for common behavioural and mental health problems in the teens and early twenties. These problems included depression and anxiety, smoking, heavy alcohol consumption, illicit drug use, deliberate self-harm, obesity, eating disorder, sexually risky behaviour, intravenous drug use, antisocial behaviours and accidental injury. This follow-up of participants at the age of 24 to 25 years will ascertain persisting rates of these problems including levels of substance dependence and mental disorder. Social outcomes such as educational achievement, employment, relationships, parenthood and friendships will be ascertained. In addition mouth washes will be used to collect DNA to allow investigation of genes that may make a contribution to more severe mental disorder and substance dependency. This study will give a clear picture of the outcome and consquences of common adolescent health problems. It will also clarify further psychosocial factors that contribute to their onset or outcome. Together with an analysis of candidate genes the study should make a great contribution to the information necessary for planning effective preventive intervention.Read moreRead less
An Investigation Of The Role Of The Pre-frontal Cortex In Cognitive Ageing And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$291,629.00
Summary
This project will investigate the role of the pre-frontal cortex in cognitive ageing and dementia. New neuroimaging techniques will be used to precisely measure this cerebral structure in a large ageing cohort The new brain measures will be used to identify risk and protective factors of cognitive ageing and dementia. This project is highly significant because it will contribute to the identification of at risk individuals and guide future intervention and clinical studies.