Autoimmune-based thrombocytopenia can be a life-threatening adverse event associated with viral load, surgery, drug therapies or the use of the anticoagulant, heparin. This grant will define mechanisms of anti-platelet antibody-dependent platelet activation and assess shedding of platelet-specific glycoprotein (GP)VI as an immediate consequence of this activation, provide a new strategy for evaluating risk of thrombosis in HIT.
Remote forcing of Pacific Ocean variability and impacts on global climate. Variability in the Pacific Ocean has a profound impact on global climate. Recent unprecedented decadal variability in the Pacific has been linked to global temperature trends and extremes, yet little is known about what drives this variability or its impact on regional climate. This project will combine observations, advanced coupled climate models and ocean-atmosphere dynamical theory to quantify remote drivers of Pacifi ....Remote forcing of Pacific Ocean variability and impacts on global climate. Variability in the Pacific Ocean has a profound impact on global climate. Recent unprecedented decadal variability in the Pacific has been linked to global temperature trends and extremes, yet little is known about what drives this variability or its impact on regional climate. This project will combine observations, advanced coupled climate models and ocean-atmosphere dynamical theory to quantify remote drivers of Pacific Ocean variability on interannual-decadal time-scales. This project aims to enhance our understanding of the modes of variability operating in this region and their impact on global and Australian climate. This will have significant benefits for the many sectors of society reliant on interseasonal-decadal climate prediction.Read moreRead less
Megadrought likelihood and its water resource impacts in Australia. This interdisciplinary project plans to assemble a world-class team of hydrologists, climate scientists and water managers to investigate the history and future risk of decadal to multidecadal droughts (megadroughts). Despite Australia’s vulnerability to water scarcity, the likelihood of persistent megadroughts has not been assessed in Australia. This has resulted in inadequate capacity to prepare for and adapt to megadrought un ....Megadrought likelihood and its water resource impacts in Australia. This interdisciplinary project plans to assemble a world-class team of hydrologists, climate scientists and water managers to investigate the history and future risk of decadal to multidecadal droughts (megadroughts). Despite Australia’s vulnerability to water scarcity, the likelihood of persistent megadroughts has not been assessed in Australia. This has resulted in inadequate capacity to prepare for and adapt to megadrought under future climate change. For the first time, palaeoclimate reconstructions and climate change projections will be used to constrain future hydroclimatic variability, advancing the decision-making capacity of Australian water resource managers.Read moreRead less
Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from ....Quantifying sea-level trends and extremes along Australia's coastal margin. Multi-decadal changes in sea-level, and sea-level extremes, cannot be well quantified along most global coastlines, including Australia's, because the high spatial variability of sea-level is under-sampled by the sparse set of long, high quality tide gauge records. Satellite altimetry provides an alternative data source with greater spatial sampling, yet experiences contamination from land within tens of kilometres from the coast and also suffers from regionally correlated biases. This project proposes to address these problems through re-tracking radar altimetry waveforms to derive new data in the coastal margin, enabling the production of new inferences on sea-level change and extremes at dramatically improved spatial resolution around Australia.Read moreRead less
Evaluating the weather in climate models - the relationship of dynamics and rainfall over Australia in current and future climates. Climate change will be experienced by society as a change in the day-to-day weather. This project will investigate the capabilities of modern climate models in simulating the weather with a particular focus on rainfall, and will provide guidance to the use of these models in projections of the future of Australia's climate.
Reconstructing pre-20th century rainfall, temperature and pressure for south-eastern Australia using palaeoclimate, documentary and early weather station data. South-eastern Australia is in the grip of a severe water crisis due to the worst drought in recorded history and increasing temperatures. This landmark project brings together a team of Australia's leading climate scientists, water managers and historians with the common goal of reconstructing south-eastern Australia's climate history. Th ....Reconstructing pre-20th century rainfall, temperature and pressure for south-eastern Australia using palaeoclimate, documentary and early weather station data. South-eastern Australia is in the grip of a severe water crisis due to the worst drought in recorded history and increasing temperatures. This landmark project brings together a team of Australia's leading climate scientists, water managers and historians with the common goal of reconstructing south-eastern Australia's climate history. The greatly extended record of annual rainfall and temperature variability will allow better planning for water storage and use, and improved testing of climate model simulations. Improving our understanding of the historical impacts of climate extremes on society will assist with planning for life in a hotter and drier future.Read moreRead less
Quantifying and mitigating changes in Australia’s rainfall belts. This project aims to understand how past climate changes affected Australia’s rainfall belts, and to reverse recent changes in rainfall belts. Australia’s climate belts are moving, but it is unclear if the effects on tropical and temperate rainfall will be permanent. This project will use past climate records and palaeoclimate databases to assess how natural and human-induced changes during the past millennium affected Australia’s ....Quantifying and mitigating changes in Australia’s rainfall belts. This project aims to understand how past climate changes affected Australia’s rainfall belts, and to reverse recent changes in rainfall belts. Australia’s climate belts are moving, but it is unclear if the effects on tropical and temperate rainfall will be permanent. This project will use past climate records and palaeoclimate databases to assess how natural and human-induced changes during the past millennium affected Australia’s rainfall zones, and specialised climate model simulations to determine whether greenhouse gas reduction could mitigate future rainfall changes. The outcomes are expected to inform policy and mitigation strategies to secure Australia’s precious water resources.Read moreRead less
Space gravity: squeezing the last drop of hydrological information out of current and future missions. Australia needs space gravity measurements in order to estimate regional-scale total water storage changes on our continent. This project will deliver the analysis capability required to exploit all the measurements of the current Gravity Recovery and Climate Experiment (GRACE) mission and to place Australia in a state of readiness for the 2017 GRACE Follow On mission.
First-order reversal curve diagrams & quantitative environmental magnetism. The project intends to enable full quantitative separation of magnetic mineral mixtures in natural materials to unlock details of important environmental processes. Most efforts to understand ancient variations of Earth’s magnetic field using palaeomagnetism, or climate change using environmental magnetism, are complicated by the presence of mixed assemblages of magnetic rock-forming minerals. Understanding the recording ....First-order reversal curve diagrams & quantitative environmental magnetism. The project intends to enable full quantitative separation of magnetic mineral mixtures in natural materials to unlock details of important environmental processes. Most efforts to understand ancient variations of Earth’s magnetic field using palaeomagnetism, or climate change using environmental magnetism, are complicated by the presence of mixed assemblages of magnetic rock-forming minerals. Understanding the recording of palaeomagnetic information or decoding environmental processes requires separate quantification of each mineral component. The main aim of the project is to develop a method to unmix the magnetic components present in environmental and geological materials. The proposed approach is expected to unlock a new quantitative era in rock magnetism, and to have impacts in physics as well as Earth science.Read moreRead less
Assessing clouds and rainfall in Australia's community climate model - Towards an improved simulation of Australia's water resources. Climate change is likely to significantly affect Australia's water resources. A well-measured response to this challenge requires reliable projections of future climate using modern Earth System Models. By thoroughly evaluating Australia's community climate model this research will inform Australia's adaptation policy and through subsequent model development it wi ....Assessing clouds and rainfall in Australia's community climate model - Towards an improved simulation of Australia's water resources. Climate change is likely to significantly affect Australia's water resources. A well-measured response to this challenge requires reliable projections of future climate using modern Earth System Models. By thoroughly evaluating Australia's community climate model this research will inform Australia's adaptation policy and through subsequent model development it will contribute to significant improvements in our ability to understand and predict climate change. Through better informing water resource management the research constitutes an important contribution to an environmentally sustainable Australia. Read moreRead less